急性胰腺炎并发急性肾损伤的机制及影响因素研究

Study on the Mechanism and Influencing Factors of Acute Pancreatitis Complicated with Acute Kidney Injury

摘要: 急性胰腺炎(acute pancreatitis, AP)是临床上最常见的急腹症之一，其进展十分迅速，病程较复杂，急性胰腺炎常导致胰腺器官坏死以及胰腺组织以外器官功能的持续性衰竭，致病率和致死率较高。急性肾损伤(acute kidney injury, AKI)是急性胰腺炎常见并发症之一，通常发生在急性胰腺炎病程晚期阶段，肺、心脏等器官衰竭之后，具有较高的死亡率和并发症发生率。本研究意在探讨急性胰腺炎合并急性肾损伤的机制及影响因素，为临床治疗提供参考，以降低死亡率和并发症发生率。对近年来国内外相关文献资料进行搜集整理。结果显示，影响急性胰腺炎并发急性肾损伤的因素有感染直接损伤、炎症介质、细胞因子释放、血钙水平、高甘油三酯等导致急性肾损伤的重要因素。

Abstract: Acute pancreatitis is one of the most common acute abdominal diseases in clinical practice, which progresses rapidly and has a complex course. Acute pancreatitis often leads to necrosis of pancreatic organs and persistent failure of organ function outside of pancreatic tissue, with high incidence and mortality rates. Acute kidney injury is one of the common complications of acute pancreatitis, usually occurring in the late stage of the disease, after organ failure such as lung and heart failure, and usually has a high mortality rate and incidence of complications. This study aims to explore the mechanism and influencing factors of acute pancreatitis combined with acute kidney injury, providing reference for clinical treatment to reduce mortality and complication rates. The results showed that factors affecting acute pancreatitis complicated with acute kidney injury include direct infection injury, inflammatory mediators, cytokine release, blood calcium levels, high triglycerides, and other important factors leading to acute kidney injury.