原发性头痛与认知的关系
The Relationship between Primary Headache and Cognition
DOI: 10.12677/jcpm.2025.41068, PDF,   
作者: 曹伊凡:济宁医学院临床医学院(附属医院),山东 济宁;李若林, 徐 鹏*:济宁医学院附属医院神经内科,山东 济宁
关键词: 原发性头痛认知障碍认知行为疗法Primary Headache Cognitive Impairment Cognitive Behavioral Therapy
摘要: 头痛是一种常见的症状,在临床实践研究中引起了广泛的关注。近年来,研究发现头痛与认知功能之间存在密切的关系。该综述旨在系统回顾已有的研究,探讨头痛对认知功能的影响。研究显示,头痛可以导致注意力、记忆、执行功能和信息处理速度等认知功能的下降。同时,认知功能的变化也可能与头痛的发生和发展有关。各种认知干预手段,可以有效调节头痛的症状和情绪反应。未来的研究可以进一步探讨头痛和认知之间的机制和关系,并开发更多的认知干预手段,以提高头痛患者的认知能力和生活质量。
Abstract: Headache is a common symptom that has attracted widespread attention in clinical practice and research. In recent years, studies have found a close relationship between headache and cognitive function. The aim of this review is to systematically review the existing studies on the effects of headache on cognitive function and the effects of cognitive function on headache. Studies have shown that headache can lead to a decline in cognitive functions such as attention, memory, executive function, and information processing speed. At the same time, changes in cognitive function may be related to the onset and progression of headache. Various cognitive interventions can be effective in modulating symptoms and emotional responses to headache. Future studies can further explore the mechanisms and relationships between headache and cognition, and develop more cognitive interventions to improve cognitive ability and quality of life of headache patients.
文章引用:曹伊凡, 李若林, 徐鹏. 原发性头痛与认知的关系[J]. 临床个性化医学, 2025, 4(1): 455-462. https://doi.org/10.12677/jcpm.2025.41068

参考文献

[1] Wang, M., Pan, W., Xu, Y., Zhang, J., Wan, J. and Jiang, H. (2022) Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases. Journal of Inflammation Research, 15, 3083-3094. [Google Scholar] [CrossRef] [PubMed]
[2] Gil-Gouveia, R., Oliveira, A.G. and Martins, I.P. (2014) Cognitive Dysfunction during Migraine Attacks: A Study on Migraine without Aura. Cephalalgia, 35, 662-674. [Google Scholar] [CrossRef] [PubMed]
[3] Riva, D., Usilla, A., Aggio, F., Vago, C., Treccani, C. and Bulgheroni, S. (2011) Attention in Children and Adolescents with Headache. Headache: The Journal of Head and Face Pain, 52, 374-384. [Google Scholar] [CrossRef] [PubMed]
[4] Huang, L., juan Dong, H., Wang, X., Wang, Y. and Xiao, Z. (2017) Duration and Frequency of Migraines Affect Cognitive Function: Evidence from Neuropsychological Tests and Event-Related Potentials. The Journal of Headache and Pain, 18, Article No. 54. [Google Scholar] [CrossRef] [PubMed]
[5] Zucca, M., Rubino, E., Vacca, A., De Martino, P., Roveta, F., Govone, F., et al. (2020) Metacognitive Impairment in Patients with Episodic and Chronic Migraine. Journal of Clinical Neuroscience, 72, 119-123. [Google Scholar] [CrossRef] [PubMed]
[6] Migliore, S., D’Aurizio, G., Altamura, C., Brunelli, N., Costa, C., Curcio, G., et al. (2022) Task-Switching Abilities in Episodic and Chronic Migraine. Neurological Sciences, 43, 3803-3810. [Google Scholar] [CrossRef] [PubMed]
[7] Su, M., Wang, R., Dong, Z., Zhao, D. and Yu, S. (2021) Decline in Attentional Inhibition among Migraine Patients: An Event‐Related Potential Study Using the Stroop Task. The Journal of Headache and Pain, 22, Article No. 34. [Google Scholar] [CrossRef] [PubMed]
[8] Raimo, S., d’Onofrio, F., Gaita, M., Costanzo, A. and Santangelo, G. (2022) Neuropsychological Correlates of Theory of Mind in Chronic Migraine. Neuropsychology, 36, 753-763. [Google Scholar] [CrossRef] [PubMed]
[9] Braganza, D.L., Fitzpatrick, L.E., Nguyen, M.L. and Crowe, S.F. (2021) Interictal Cognitive Deficits in Migraine Sufferers: A Meta-Analysis. Neuropsychology Review, 32, 736-757. [Google Scholar] [CrossRef] [PubMed]
[10] Öze, A., Nagy, A., Benedek, G., Bodosi, B., Kéri, S., Pálinkás, É., et al. (2016) Acquired Equivalence and Related Memory Processes in Migraine without Aura. Cephalalgia, 37, 532-540. [Google Scholar] [CrossRef] [PubMed]
[11] Maleki, N., Becerra, L., Nutile, L., Pendse, G., Brawn, J., Bigal, M., et al. (2011) Migraine Attacks the Basal Ganglia. Molecular Pain, 7. [Google Scholar] [CrossRef] [PubMed]
[12] Zhang, X., Zhou, J., Guo, M., Cheng, S., Chen, Y., Jiang, N., et al. (2022) A Systematic Review and Meta-Analysis of Voxel-Based Morphometric Studies of Migraine. Journal of Neurology, 270, 152-170. [Google Scholar] [CrossRef] [PubMed]
[13] Gu, L., Shu, H. and Wang, Y. (2023) Functional Brain Alterations in Migraine Patients: An Activation Likelihood Estimation Study. Neurological Research, 45, 717-724. [Google Scholar] [CrossRef] [PubMed]
[14] Dai, L., Yu, Y., Zhao, H., Zhang, X., Su, Y., Wang, X., et al. (2020) Altered Local and Distant Functional Connectivity Density in Chronic Migraine: A Resting-State Functional MRI Study. Neuroradiology, 63, 555-562. [Google Scholar] [CrossRef] [PubMed]
[15] Qin, Z., Su, J., He, X., Ban, S., Zhu, Q., Cui, Y., et al. (2020) Disrupted Functional Connectivity between Sub-Regions in the Sensorimotor Areas and Cortex in Migraine without Aura. The Journal of Headache and Pain, 21, Article No. 47. [Google Scholar] [CrossRef] [PubMed]
[16] Qin, Z.X., Su, J.J., He, X.W., Zhu, Q., Cui, Y.Y., Zhang, J.L., et al. (2020) Altered Resting‐State Functional Connectivity between Subregions in the Thalamus and Cortex in Migraine without Aura. European Journal of Neurology, 27, 2233-2241. [Google Scholar] [CrossRef] [PubMed]
[17] David, M.C.M.M., Santos, B.S.D., Barros, W.M.A., Silva, T.R.L.D., Franco, C.I.F. and Matos, R.J.B.D. (2020) Neuroimaging Investigation of Memory Changes in Migraine: A Systematic Review. Arquivos de Neuro-Psiquiatria, 78, 370-379. [Google Scholar] [CrossRef] [PubMed]
[18] Lévêque, Y., Masson, R., Fornoni, L., Moulin, A., Bidet-Caulet, A., Caclin, A., et al. (2020) Self-Perceived Attention Difficulties Are Associated with Sensory Hypersensitivity in Migraine. Revue Neurologique, 176, 829-838. [Google Scholar] [CrossRef] [PubMed]
[19] Gu, L., Wang, Y. and Shu, H. (2022) Association between Migraine and Cognitive Impairment. The Journal of Headache and Pain, 23, Article No. 88. [Google Scholar] [CrossRef] [PubMed]
[20] Kreczmański, P., Wolak, T., Lewandowska, M. and Domitrz, I. (2019) Altered Functional Brain Imaging in Migraine Patients: BOLD Preliminary Study in Migraine with and without Aura. Neurologia i Neurochirurgia Polska, 53, 304-310. [Google Scholar] [CrossRef] [PubMed]
[21] Kuhajda, M.C., Thorn, B.E., Klinger, M.R. and Rubin, N.J. (2002) The Effect of Headache Pain on Attention (Encoding) and Memory (Recognition). Pain, 97, 213-221. [Google Scholar] [CrossRef] [PubMed]
[22] Latysheva, N., Filatova, E., Osipova, D. and Danilov, A.B. (2020) Cognitive Impairment in Chronic Migraine: A Cross-Sectional Study in a Clinic-Based Sample. Arquivos de Neuro-Psiquiatria, 78, 133-138. [Google Scholar] [CrossRef] [PubMed]
[23] Genizi, J., Halevy, A., Schertz, M., Osman, K., Assaf, N., Segal, I., et al. (2020) Sensory Processing Patterns Affect Headache Severity among Adolescents with Migraine. The Journal of Headache and Pain, 21, Article No. 48. [Google Scholar] [CrossRef] [PubMed]
[24] Viero, F.T., Rodrigues, P. and Trevisan, G. (2022) Cognitive or Daily Stress Association with Headache and Pain Induction in Migraine and Tension-Type Headache Patients: A Systematic Review. Expert Review of Neurotherapeutics, 22, 257-268. [Google Scholar] [CrossRef] [PubMed]
[25] Qu, P., Yu, J., Xia, L. and Chen, G. (2017) Cognitive Performance and the Alteration of Neuroendocrine Hormones in Chronic Tension‐Type Headache. Pain Practice, 18, 8-17. [Google Scholar] [CrossRef] [PubMed]
[26] Torkamani, M., Ernst, L., Cheung, L.S., Lambru, G., Matharu, M. and Jahanshahi, M. (2015) The Neuropsychology of Cluster Headache: Cognition, Mood, Disability, and Quality of Life of Patients with Chronic and Episodic Cluster Headache. Headache: The Journal of Head and Face Pain, 55, 287-300. [Google Scholar] [CrossRef] [PubMed]
[27] Santos-Lasaosa, S., Bellosta-Diago, E., López-Bravo, A., Viloria-Alebesque, A., Garrido-Fernández, A. and Pilar Navarro-Pérez, M. (2018) Cognitive Performance in Episodic Cluster Headache. Pain Medicine, 20, 1032-1037. [Google Scholar] [CrossRef] [PubMed]
[28] Navarro‐Pérez, M.P., Bellosta‐Diago, E., Viloria‐Alebesque, A., Garrido‐Fernández, A., López‐Bravo, A. and Santos‐Lasaosa, S. (2021) Cognitive Performance in Patients with Episodic Cluster Headache Outside and Inside the Active Cluster. Headache: The Journal of Head and Face Pain, 61, 209-215. [Google Scholar] [CrossRef] [PubMed]
[29] Ballesta-Martínez, S., del Pilar Navarro-Pérez, M., Bellosta-Diago, E. and Santos-Lasaosa, S. (2022) Theory of Mind: A New Perspective on Cluster Headache—A Cross-Sectional Study. Neurological Sciences, 43, 6047-6051. [Google Scholar] [CrossRef] [PubMed]
[30] Demichelis, G., Pinardi, C., Giani, L., Medina, J.P., Gianeri, R., Bruzzone, M.G., et al. (2021) Chronic Cluster Headache: A Study of the Telencephalic and Cerebellar Cortical Thickness. Cephalalgia, 42, 444-454. [Google Scholar] [CrossRef] [PubMed]
[31] DaSilva, A.F., Zubieta, J. and DosSantos, M.F. (2019) Positron Emission Tomography Imaging of Endogenous Mu-Opioid Mechanisms during Pain and Migraine. PAIN Reports, 4, e769. [Google Scholar] [CrossRef] [PubMed]
[32] Schmidt-Wilcke, T., Leinisch, E., Straube, A., Kämpfe, N., Draganski, B., Diener, H.C., et al. (2005) Gray Matter Decrease in Patients with Chronic Tension Type Headache. Neurology, 65, 1483-1486. [Google Scholar] [CrossRef] [PubMed]
[33] Xiang, Y., Chen, S., Lin, H., Xiong, W. and Zheng, Z. (2021) Cognitive Function and White Matter Lesions in Medication-Overuse Headache. Journal of Pain Research, 14, 1845-1853. [Google Scholar] [CrossRef] [PubMed]
[34] Morrison, C., Dadar, M., Villeneuve, S. and Collins, D.L. (2022) White Matter Lesions May Be an Early Marker for Age-Related Cognitive Decline. NeuroImage: Clinical, 35, Article ID: 103096. [Google Scholar] [CrossRef] [PubMed]
[35] Rezvani, F., Sayadnasiri, M. and Rezaei, O. (2017) The Study of Memory and Executive Dysfunction in Patients Infected with Helicobacter pylori. Neurological Research, 39, 953-958. [Google Scholar] [CrossRef] [PubMed]
[36] Han, M., Chen, J., Tsai, M., Liou, J., Chiou, J., Chiu, M., et al. (2018) Association between Helicobacter pylori Infection and Cognitive Impairment in the Elderly. Journal of the Formosan Medical Association, 117, 994-1002. [Google Scholar] [CrossRef] [PubMed]
[37] Öcal, S., Öcal, R. and Suna, N. (2022) Relationship between Helicobacter Pylori Infection and White Matter Lesions in Patients with Migraine. BMC Neurology, 22, Article No. 187. [Google Scholar] [CrossRef] [PubMed]
[38] Bao, S., Qiao, M., Lu, Y. and Jiang, Y. (2022) Neuroimaging Mechanism of Cognitive Behavioral Therapy in Pain Management. Pain Research and Management, 2022, Article ID: 6266619. [Google Scholar] [CrossRef] [PubMed]
[39] Amatrudo, G., Kengetter, J., McCrea, S. and Amatrudo, M. (2023) Cognitive Behavioral Therapy for the Management of Episodic Migraine. Current Pain and Headache Reports, 27, 471-477. [Google Scholar] [CrossRef] [PubMed]
[40] Nahman‐Averbuch, H., Schneider, V.J., Chamberlin, L.A., Kroon Van Diest, A.M., Peugh, J.L., Lee, G.R., et al. (2020) Alterations in Brain Function after Cognitive Behavioral Therapy for Migraine in Children and Adolescents. Headache: The Journal of Head and Face Pain, 60, 1165-1182. [Google Scholar] [CrossRef] [PubMed]
[41] Bae, J., Sung, H., Kwon, N., Go, H., Kim, T., Shin, S., et al. (2021) Cognitive Behavioral Therapy for Migraine Headache: A Systematic Review and Meta-Analysis. Medicina, 58, Article 44. [Google Scholar] [CrossRef] [PubMed]