血管包绕肿瘤细胞巢癌巢型肝细胞肝癌研究进展
Research Progress on Carcinoma with Nested Pattern of Hepatocellular Carcinoma Surrounded by Blood Vessels
DOI: 10.12677/jcpm.2025.41070, PDF,   
作者: 文怡钦：济宁医学院临床医学院(附属医院)，山东 济宁；刘艳荣*：济宁医学院附属医院病理科，山东 济宁
关键词: 肝细胞肝癌；血管包绕肿瘤细胞巢；转移；诊断；治疗；Hepatocellular Carcinoma (HCC)； Vessels Surrounded Tumor Clusters (VETC)； Metastasis； Diagnosis； Treatment
摘要: 大部分原发性肝癌转移模式的理论基础是上皮–间质转化(epithelial-mesenchymal transition, EMT)，但是在肝细胞肝癌中，发现了一种新的临床亚型——血管包绕肿瘤细胞巢(vessels surrounded tumor clusters, VETC)癌巢型肝细胞肝癌，它具有特殊的血管结构模式，它的转移是一种非依赖EMT转移的方式，癌巢通过外周血液循环进行转移，最后形成新的癌转移灶，具有高复发率，高死亡率的特点。本文将对VETC癌巢型HCC目前研究出的转移方式、诊断及预测价值，治疗方式以及分子学特征四个方面进行阐述。
Abstract: Most of the metastatic models of primary liver cancer are based on Epithelial-mesenchymal transition (EMT). But in hepatocellular carcinoma, a new clinical subtype, vascular enveloping tumor cell nest vessels surrounded tumor clusters (VETC), has been found. It has a special vascular structure pattern, and its metastasis is independent of EMT metastasis, and the cancer nest metastases through peripheral blood circulation. Finally, a new metastatic focus is formed, which has the characteristics of high recurrence rate and high mortality rate. This article will describe the metastasis mode, diagnostic and predictive value, treatment methods and molecular characteristics of VETC cancer nest HCC.
文章引用：文怡钦, 刘艳荣. 血管包绕肿瘤细胞巢癌巢型肝细胞肝癌研究进展[J]. 临床个性化医学, 2025, 4(1): 471-477. https://doi.org/10.12677/jcpm.2025.41070

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