炎症相关指标对高增殖活性胃肠神经内分泌肿瘤预后的价值分析

Analysis of the Prognostic Value of Inflammation-Related Biomarkers in Gastrointestinal Neuroendocrine Neoplasms with High Proliferative Activity

摘要: 目的：探讨炎症相关指标在高增殖活性胃肠神经内分泌肿瘤预后中的临床意义，为其患者的预后提供参考依据。方法：回顾性分析青岛大学附属医院2017~2022年48例高增殖活性胃肠神经内分泌肿瘤患者的临床资料，采用Cox回归模型进行单因素及多因素分析，Kaplan‑Meier方法进行生存分析。结果：单因素Cox回归模型显示高血压病史、肝转移、NLR、GLR是预后的影响因素(P < 0.05)，多因素Cox回归模型结果显示，NLR升高、肝转移是预后的独立危险因素(P < 0.05)；Kaplan‑Meier生存分析结果表明，NLR高组、GLR高组患者的生存期较短。结论：NLR、GLR对高增殖活性胃肠神经内分泌肿瘤患者预后有预测价值。

Abstract: Objective: This study aims to explore the clinical significance of inflammation-related biomarkers in predicting the prognosis of high-proliferative gastrointestinal neuroendocrine neoplasms (GI-NENs), thereby providing a reference for patient management. Methods: A retrospective analysis was conducted on the clinical data of 48 patients diagnosed with high-proliferative GI-NENs at the Affiliated Hospital of Qingdao University between 2017 and 2022. Univariate and multivariate Cox regression models were employed to identify prognostic factors, while Kaplan-Meier survival analysis was used to evaluate survival outcomes. Results: The univariate Cox regression analysis revealed that hypertension history, liver metastasis, neutrophil-to-lymphocyte ratio (NLR), and glycoprotein acetylation ratio (GLR) were significant predictors of prognosis (P < 0.05). Multivariate Cox regression analysis further indicated that NLR and liver metastasis were independent risk factors for poor prognosis (P < 0.05). Kaplan-Meier survival curves demonstrated that patients with elevated NLR and GLR had significantly shorter survival times. Conclusion: Both NLR and GLR serve as valuable indicators for predicting the prognosis of patients with high-proliferative GI-NENs.