一例继发性卵巢恶性肿瘤病例报道并文献学习
A Case Report of Secondary Ovarian Malignant Tumor and Literature Study
DOI: 10.12677/acm.2025.152448, PDF,    科研立项经费支持
作者: 陈 曦*, 古艳菲*, 林伟钊#：暨南大学附属第一医院妇产科，广东 广州
关键词: Krukenberg瘤；结直肠肿瘤；疾病护理；Krukenberg-Tumor； Colorectal Neoplasia； Disease Nursing
摘要: 卵巢是转移性肿瘤的好发部位，继发性卵巢肿瘤常来源于胃肠道(最常见)、乳房和泌尿生殖道。近年来肠来源继发性恶性肿瘤有逐渐上升趋势，其临床症状与影像学多无特异性表现。本研究以一例继发性卵巢肿瘤为例，通过讨论病史、疾病临床特征、手术与化疗方案及护理的影响，进一步指导患者诊疗及护理。
Abstract: The ovary is a common site for metastatic tumors, and secondary ovarian tumors often originate from the gastrointestinal tract (most commonly), breast, and urogenital tract. In recent years, secondary malignant tumors of enteric origin have been on the rise gradually, and their clinical symptoms and imaging findings are mostly non-specific. In this study, a case of secondary ovarian tumor was taken as an example to further guide the diagnosis, treatment and nursing of the patient by discussing the history, clinical features of the disease, the influence of surgery and chemotherapy and nursing.
文章引用：陈曦, 古艳菲, 林伟钊. 一例继发性卵巢恶性肿瘤病例报道并文献学习[J]. 临床医学进展, 2025, 15(2): 1086-1094. https://doi.org/10.12677/acm.2025.152448

参考文献

[1] Koyama, T., Mikami, Y., Saga, T., Tamai, K. and Togashi, K. (2007) Secondary Ovarian Tumors: Spectrum of CT and MR Features with Pathologic Correlation. Abdominal Imaging, 32, 784-795. [Google Scholar] [CrossRef] [PubMed]
[2] Kato, N., Hayasaka, T., Takeda, J., Osakabe, M. and Kurachi, H. (2013) Ovarian Tumors with Functioning Stroma. International Journal of Gynecological Pathology, 32, 556-561. [Google Scholar] [CrossRef] [PubMed]
[3] Tan, K., Tan, W., Lim, J. and Eu, K. (2009) Krukenberg Tumors of Colorectal Origin: A Dismal Outcome—Experience of a Tertiary Center. International Journal of Colorectal Disease, 25, 233-238. [Google Scholar] [CrossRef] [PubMed]
[4] Fidler, I.J. (2003) The Pathogenesis of Cancer Metastasis: The “Seed and Soil” Hypothesis Revisited. Nature Reviews Cancer, 3, 453-458. [Google Scholar] [CrossRef] [PubMed]
[5] 高福锋, 李大海, 范江涛. 晚期卵巢癌肿瘤细胞减灭术的理论基础及应用进展[J]. 癌症进展, 2024, 22(16): 1741-1745.
[6] Jiang, R., Tang, J., Cheng, X. and Zang, R.Y. (2009) Surgical Treatment for Patients with Different Origins of Krukenberg Tumors: Outcomes and Prognostic Factors. European Journal of Surgical Oncology, 35, 92-97. [Google Scholar] [CrossRef] [PubMed]
[7] Brown, D.L., Zou, K.H., Tempany, C.M.C., Frates, M.C., Silverman, S.G., McNeil, B.J., et al. (2001) Primary versus Secondary Ovarian Malignancy: Imaging Findings of Adnexal Masses in the Radiology Diagnostic Oncology Group Study. Radiology, 219, 213-218. [Google Scholar] [CrossRef] [PubMed]
[8] 郭永梅, 黄云海, 江新青. 继发性卵巢腺癌的CT和MR影像特点及诊断价值[J]. 医学影像学杂志, 2011, 21(4): 583-587.
[9] 郑娇, 王功伟, 刘文婷, 沈丹华. 卵巢Krukenberg瘤21例分析报道[J]. 诊断病理学杂志, 2017, 24(7): 544-547.
[10] McCluggage, W.G. and Young, R.H. (2008) Primary Ovarian Mucinous Tumors with Signet Ring Cells. American Journal of Surgical Pathology, 32, 1373-1379. [Google Scholar] [CrossRef] [PubMed]
[11] 曹晖, 邱江锋, 赵刚. 胃癌卵巢转移临床治疗决策[J]. 中国实用外科杂志, 2015, 35(10): 1065-1068.
[12] Cheong, J.H., Hyung, W.J., Chen, J., Kim, J., Choi, S.H. and Noh, S.H. (2004) Survival Benefit of Metastasectomy for Krukenberg Tumors from Gastric Cancer. Gynecologic Oncology, 94, 477-482. [Google Scholar] [CrossRef] [PubMed]
[13] Feng, Q., Pei, W., Zheng, Z.X., et al. (2013) Clinicopathologic Characteristics and Prognostic Factors of 63 Gastric Cancer Patients with Metachronous Ovarian Metastasis. Cancer Biology & Medicine, 10, 86-91. [Google Scholar] [CrossRef] [PubMed]
[14] Peng, W., Hua, R., Jiang, R., Ren, C., Jia, Y., Li, J., et al. (2013) Surgical Treatment for Patients with Krukenberg Tumor of Stomach Origin: Clinical Outcome and Prognostic Factors Analysis. PLOS ONE, 8, e68227. [Google Scholar] [CrossRef] [PubMed]
[15] Jun, S. and Park, J.K. (2011) Metachronous Ovarian Metastases Following Resection of the Primary Gastric Cancer. Journal of Gastric Cancer, 11, 31-37. [Google Scholar] [CrossRef] [PubMed]
[16] Yu, P., Huang, L., Cheng, G., Yang, L., Dai, G., Ying, J., et al. (2017) Treatment Strategy and Prognostic Factors for Krukenberg Tumors of Gastric Origin: Report of a 10-Year Single-Center Experience from China. Oncotarget, 8, 82558-82570. [Google Scholar] [CrossRef] [PubMed]
[17] Cho, J.H., Lim, J.Y., Choi, A.R., Choi, S.M., Kim, J.W., Choi, S.H., et al. (2018) ERRATUM: Comparison of Surgery Plus Chemotherapy and Palliative Chemotherapy Alone for Advanced Gastric Cancer with Krukenberg Tumor. Cancer Research and Treatment, 50, 302-302. [Google Scholar] [CrossRef] [PubMed]
[18] Lu, L.C., Shao, Y.Y., Hsu, C.H., et al. (2012) Metastasectomy of Krukenberg Tumors May Be Associated with Survival Benefits in Patients with Metastatic Gastric Cancer. Anticancer Research, 32, 3397-3401.
[19] Lonardi, S., Rasola, C., Lobefaro, R., Rossini, D., Formica, V., Scartozzi, M., et al. (2023) Initial Panitumumab Plus Fluorouracil, Leucovorin, and Oxaliplatin or Plus Fluorouracil and Leucovorin in Elderly Patients with RAS and BRAF Wild-Type Metastatic Colorectal Cancer: The PANDA Trial by the GONO Foundation. Journal of Clinical Oncology, 41, 5263-5273. [Google Scholar] [CrossRef] [PubMed]
[20] Kopetz, S., Grothey, A., Van Cutsem, E., Yaeger, R., Wasan, H., Yoshino, T., et al. (2022) Quality of Life with Encorafenib Plus Cetuximab with or without Binimetinib Treatment in Patients with BRAF V600e-Mutant Metastatic Colorectal Cancer: Patient-Reported Outcomes from BEACON CRC. ESMO Open, 7, Article 100477. [Google Scholar] [CrossRef] [PubMed]
[21] Tejpar, S., Stintzing, S., Ciardiello, F., Tabernero, J., Van Cutsem, E., Beier, F., et al. (2017) Prognostic and Predictive Relevance of Primary Tumor Location in Patients with RAS Wild-Type Metastatic Colorectal Cancer. JAMA Oncology, 3, 194-201. [Google Scholar] [CrossRef] [PubMed]
[22] Holch, J.W., Ricard, I., Stintzing, S., Modest, D.P. and Heinemann, V. (2017) The Relevance of Primary Tumour Location in Patients with Metastatic Colorectal Cancer: A Meta-Analysis of First-Line Clinical Trials. European Journal of Cancer, 70, 87-98. [Google Scholar] [CrossRef] [PubMed]
[23] 重庆市医学会肿瘤学分会化疗学组, 重庆大学附属肿瘤医院结直肠癌MDT专家组. 结直肠癌化疗合理用药原则专家共识[J]. 中国医院用药评价与分析, 2023, 23(9): 1025-1040.
[24] Punt, C., Smith, D., et al. (2022) Pembrolizumab versus Chemotherapy for Microsatellite Instability-High/Mismatch Repair Deficient Metastatic Colorectal Cancer: The Phase 3 KEYNOTE-177 Study. The Lancet Oncology, 23, 659-670.
[25] Xu, R., Wang, F., Chen, G., Qiu, M., Ma, J., Liu, H., et al. (2024) Neoadjuvant Treatment of IBI310 (Anti-CTLA-4 Antibody) Plus Sintilimab (Anti-PD-1 Antibody) in Patients with Microsatellite Instability-High/Mismatch Repair-Deficient Colorectal Cancer: Results from a Randomized, Open-Labeled, Phase Ib Study. Journal of Clinical Oncology, 42, 3505-3505. [Google Scholar] [CrossRef] 
[26] 郝媛媛, 杨皓辰, 荣文杰, 荣阳, 孟肖, 荣根满. 雷替曲塞联合贝伐珠单抗对晚期结直肠癌患者肿瘤标志物及基质金属蛋白酶的影响[J]. 中国当代医药, 2024, 31(22): 63-67.
[27] Temkin, S.M., Smeltzer, M.P., Dawkins, M.D., Boehmer, L.M., Senter, L., Black, D.R., et al. (2021) Improving the Quality of Care for Patients with Advanced Epithelial Ovarian Cancer: Program Components, Implementation Barriers, and Recommendations. Cancer, 128, 654-664. [Google Scholar] [CrossRef] [PubMed]
[28] Hudon, C., Chouinard, M., Dumont-Samson, O., Gobeil-Lavoie, A., Morneau, J., Paradis, M., et al. (2023) Integrated Case Management between Primary Care Clinics and Hospitals for People with Complex Needs Who Frequently Use Healthcare Services in Canada: A Multiple-Case Embedded Study. Health Policy, 132, Article 104804. [Google Scholar] [CrossRef] [PubMed]
[29] 张燕丽, 王霞, 游菁, 杨岚, 蔡慧媛. 卵巢癌患者个案管理实践方案的构建及初步应用[J]. 复旦学报(医学版), 2024, 51(5): 667-676.
[30] 黄伟政, 于利. 基于ERAS的医护一体化管理对卵巢癌患者心理状态与生活质量的影响[J]. 当代护士(下旬刊), 2024, 31(12): 72-75.
[31] 蒋琴琴, 陈荣珠, 朱荣荣. 多学科协作快速康复外科在卵巢癌瘤体减灭术围术期的应用[J]. 安徽医专学报, 2024, 23(5): 113-115.
[32] Wu, Y.L., Padmalatha K.M., S., Yu, T., Lin, Y., Ku, H., Tsai, Y., et al. (2021) Is Nurse-Led Case Management Effective in Improving Treatment Outcomes for Cancer Patients? A Systematic Review and Meta-Analysis. Journal of Advanced Nursing, 77, 3953-3963. [Google Scholar] [CrossRef] [PubMed]

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