儿童过敏性紫癜复发的相关因素分析

Analysis of Factors Related to the Recurrence of Henoch-Schonlein Purpura in Children

摘要: 目的：探讨过敏性紫癜(HSP)复发的相关因素。方法：选取2020年1月1日至2023年6月30日于安徽医科大学附属巢湖医院儿科住院的140例初次诊断为HSP的患者为研究对象。根据是否复发分为复发组(n = 51)和非复发组(n = 89)，比较两组实验室指标及临床指标，采用二元Logistic回归分析儿童HSP复发的危险因素。结果：复发组D-二聚体、IgA、PLT水平高于非复发组(P < 0.05)，复发组在皮疹持续超过两周、尿蛋白阳性、皮疹部位大于1处方面，与非复发组存在显著差异，差异具有统计学意义(P < 0.05)；二元Logistic回归分析显示，皮疹持续时间大于2周、D-二聚体、皮疹部位大于1处、IgA是HSP复发的独立危险因素(P < 0.05)。

Abstract: Objective: To investigate the factors related to the recurrence of Henoch-Schonlein purpura (HSP). Methods: The study selected 140 patients initially diagnosed with HSP who were hospitalized in the Department of Pediatrics at Chaohu Hospital affiliated with Anhui Medical University from January 1, 2020 to June 30, 2023 were enrolled as the study subjects. According to whether there was a recurrence, the children were divided into a recurrence group (n = 51) and a non-recurrence group (n = 89), and the laboratory and clinical indexes of the two groups were compared, and the risk factors of HSP recurrence in children were analyzed by binary logistic regression. Results: The levels of D-dimer, IgA and PLT in the recurrence group were higher than those in the non-recurrence group (P < 0.05), and there were significant differences between the recurrence group and the non-recurrence group in terms of rash lasting for more than two weeks, positive urine protein, and more than one rash site (P < 0.05). Binary logistic regression analysis showed that the duration of the rash was greater than 2 weeks, D-dimer, and the rash site was greater than 1, and IgA were independent risk factors for HSP recurrence (P < 0.05).