前列腺高级别B细胞淋巴瘤1例并文献复习

High-Grade B-cell Lymphoma of the Prostate: One Case Report and Literature Review

摘要: 目的：前列腺高级别B细胞淋巴瘤较为罕见，本文回顾性分析1例前列腺高级别B细胞淋巴瘤患者的临床资料，进一步探讨前列腺高级别B细胞淋巴瘤的诊断和鉴别诊断。方法：回顾我院1例原发病灶在前列腺的一种具有侵袭性较强的非霍奇金淋巴瘤的临床资料，分析其临床表现、实验室检查结果及诊治经过。结果：该患者血清前列腺特异性抗原(PSA) < 4 μg/L，fPSA/tPSA > 0.15，B超提示前列腺增生，见钙化灶，未见明显结节病灶。组织病理学符合高级别B细胞淋巴瘤。结论：前列腺高级别B细胞淋巴瘤实验室检查及B超检查特征性不强，对临床诊断价值有限，与前列腺相关疾病鉴别困难，确诊该病通常需借助于前列腺穿刺活检或手术后前列腺标本病检。

Abstract: Objective: High-grade B-cell Lymphoma of the Prostate is relatively rare. This article retrospectively analyzes the clinical data of a patient with high-grade B-cell lymphoma of the prostate and further explores the diagnosis and differential diagnosis of high-grade B-cell lymphoma of the prostate. Methods: The clinical data of a case of highly aggressive non-Hodgkin lymphoma with the primary lesion in the prostate in our hospital were retrospectively reviewed, and its clinical manifestations, laboratory test results, and diagnosis and treatment process were analyzed. Results: In this patient, the serum prostate specific antigen (PSA) was <4 μg/L, fPSA/tPSA > 0.15. Ultrasonography showed prostatic hyperplasia with calcification foci and no obvious nodular lesions. Histopathology was consistent with high grade B cell lymphoma. Conclusion: Laboratory tests and ultrasonography for high-grade B-cell lymphoma of the prostate are not highly characteristic, have limited value for clinical diagnosis, and are difficult to differentiate from prostate related diseases. Diagnosis of this disease usually requires prostate biopsy or pathological examination of prostate specimens after surgery.