基于网络药理学研究芍药甘草汤治疗儿童功能性腹痛的机制

Study on the Mechanism of Shaoyao Gancao Decoction in the Treatment of Functional Abdominal Pain in Children Based on Network Pharmacology

摘要: 目的：利用网络药理学研究芍药甘草汤治疗功能性腹痛的机制。方法：基于网络药理学，通过多种数据库进行药物化学成分的收集以及核心靶点预测；结合相关软件构建PPI网络、GO富集分析和KEGG通路分析，预测芍药甘草汤治疗儿童功能性腹痛的机制。结果：筛选出芍药甘草汤中102个活性成分，包括甘草酚、芍药苷、甘草吡喃香豆素等，治疗疾病的核心靶点蛋白11个，包含HSP90AA1、AKT1、STAT3等。KEGG通路富集分析得到20条潜在信号通路，主要涉及MAPK信号通路、HIF-1信号通路等。结论：芍药甘草汤治疗功能性腹痛具有多通路、多靶点的特性，可能通过影响MAPK信号通路、HIF-1信号通路，进而达到治疗的目的。

Abstract: Objective: To study the mechanism of Shaoyao Gancao decoction in the treatment of functional abdominal pain using network pharmacology. Methods: Based on network pharmacology, a variety of databases were used to collect chemical components and predict core targets. Combined with relevant software, PPI network, GO enrichment analysis and KEGG pathway analysis were constructed to predict the mechanism of Shaoyao Gancao decoction in the treatment of functional abdominal pain in children. Results: A total of 102 active ingredients in Shaoyao Gancao Decoction were screened, including glycyrol, paeoniflorgenone, licopyranocoumarin, etc., and 11 core target proteins were screened, including HSP90AA1, AKT1, STAT3, etc. KEGG pathway enrichment analysis identified 20 potential signaling pathways, mainly involving MAPK signaling pathway and HIF-1 signaling pathway. Conclusion: Shaoyao Gancao Decoction has the characteristics of multi-pathway and multi-target in the treatment of functional abdominal pain, and may affect the MAPK signaling pathway and HIF-1 signaling pathway to achieve the purpose of treatment.