1例巨大具有乳头样核特征的非浸润性甲状腺滤泡性肿瘤伴单侧巨大扁桃体的病案报道
A Case Report of a Huge Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and a Unilateral Giant Tonsil
摘要: 患者女性，66岁，初次就诊时可见甲状腺肿物大小约12 * 12 cm，颈部MRI示气管受压明显，但无明显呼吸困难等症状。本文通过报道了一例巨大NIFTP患者，回顾其诊疗过程，针对其定义、研究进展、诊断标准、治疗及预后进行文献回顾。
Abstract: A patient, a 66-year-old female, with a goiter about 12 * 12 cm in size at the first visit. Cervical MRI showed obvious trachea compression, but no obvious dyspnea and other symptoms. In this paper, we report a huge NIFTP patient, review its diagnosis and treatment process, and review the literature on its definition, research progress, diagnostic criteria, treatment and prognosis.
文章引用：王新语, 梅金玉. 1例巨大具有乳头样核特征的非浸润性甲状腺滤泡性肿瘤伴单侧巨大扁桃体的病案报道[J]. 临床医学进展, 2025, 15(2): 1603-1609. https://doi.org/10.12677/acm.2025.152515

参考文献

[1] Nikiforov, Y.E., Seethala, R.R., Tallini, G., Baloch, Z.W., Basolo, F., Thompson, L.D.R., et al. (2016) Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors. JAMA Oncology, 2, 1023-1029. [Google Scholar] [CrossRef] [PubMed]
[2] 刘志艳. 具有乳头样核特征的非浸润性甲状腺滤泡性肿瘤及其诊断标准[J]. 中华病理学杂志, 2017, 46(3): 205-208.
[3] Chen, K.T.K. and Rosai, J. (1977) Follicular Variant of Thyroid Papillary Carcinoma: A Clinicopathologic Study of Six Cases. The American Journal of Surgical Pathology, 1, 123-130. [Google Scholar] [CrossRef] [PubMed]
[4] Vickery, A.L., Carcangiu, M.L., Sobrinho-Simoes, M., et al. (1985) Papillary Carcinoma. Seminars in Diagnostic Pathology, 2, 90-100.
[5] Williams, E.D. (2000) Guest Editorial: Two Proposals Regarding the Terminology of Thyroid Tumors. International Journal of Surgical Pathology, 8, 181-183. [Google Scholar] [CrossRef] [PubMed]
[6] Papotti, M., Rodriguez, J., Pompa, R.D., Bartolazzi, A. and Rosai, J. (2005) Galectin-3 and HBME-1 Expression in Well-Differentiated Thyroid Tumors with Follicular Architecture of Uncertain Malignant Potential. Modern Pathology, 18, 541-546. [Google Scholar] [CrossRef] [PubMed]
[7] Zhu, Z., Gandhi, M., Nikiforova, M.N., Fischer, A.H. and Nikiforov, Y.E. (2003) Molecular Profile and Clinical-Pathologic Features of the Follicular Variant of Papillary Thyroid Carcinoma. An Unusually High Prevalence of Ras Mutations. American Journal of Clinical Pathology, 120, 71-77. [Google Scholar] [CrossRef] [PubMed]
[8] Liu, J., Singh, B., Tallini, G., Carlson, D.L., Katabi, N., Shaha, A., et al. (2006) Follicular Variant of Papillary Thyroid Carcinoma: A Clinicopathologic Study of a Problematic Entity. Cancer, 107, 1255-1264. [Google Scholar] [CrossRef] [PubMed]
[9] Widder, S., Guggisberg, K., Khalil, M. and Pasieka, J.L. (2008) A Pathologic Re-Review of Follicular Thyroid Neoplasms: The Impact of Changing the Threshold for the Diagnosis of the Follicular Variant of Papillary Thyroid Carcinoma. Surgery, 144, 80-85. [Google Scholar] [CrossRef] [PubMed]
[10] Cancer Genome Atlas Research Network (2014) Integrated Genomic Characterization of Papillary Thyroid Carcinoma. Cell, 159, 676-690.
[11] Baloch, Z. and LiVolsi, V.A. (2020) Fifty Years of Thyroid Pathology: Concepts and Developments. Human Pathology, 95, 46-54. [Google Scholar] [CrossRef] [PubMed]
[12] 方三高, 魏建国, 周晓军. WHO(2017)内分泌器官肿瘤分类解读(甲状腺) [J]. 临床与实验病理学杂志, 2018, 34(2): 119-123.
[13] Baloch, Z.W., Asa, S.L., Barletta, J.A., Ghossein, R.A., Juhlin, C.C., Jung, C.K., et al. (2022) Overview of the 2022 WHO Classification of Thyroid Neoplasms. Endocrine Pathology, 33, 27-63. [Google Scholar] [CrossRef] [PubMed]
[14] Rivera, M., Ricarte-Filho, J., Knauf, J., Shaha, A., Tuttle, M., Fagin, J.A., et al. (2010) Molecular Genotyping of Papillary Thyroid Carcinoma Follicular Variant According to Its Histological Subtypes (Encapsulated vs Infiltrative) Reveals Distinct BRAF and RAS Mutation Patterns. Modern Pathology, 23, 1191-1200. [Google Scholar] [CrossRef] [PubMed]
[15] Lee, S.E., Hwang, T.S., Choi, Y., Kim, W.Y., Han, H.S., Lim, S.D., et al. (2017) Molecular Profiling of Papillary Thyroid Carcinoma in Korea with a High Prevalence of BRAFV600E Mutation. Thyroid, 27, 802-810. [Google Scholar] [CrossRef] [PubMed]
[16] Coca-Pelaz, A., Rodrigo, J.P., Agaimy, A., Hartl, D.M., Stenman, G., Vander Poorten, V., et al. (2024) Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): What Do We Need to Know? Virchows Archiv, 485, 977-987. [Google Scholar] [CrossRef] [PubMed]
[17] Wu, H.H., Jones, J.N., Grzybicki, D.M. and Elsheikh, T.M. (2003) Sensitive Cytologic Criteria for the Identification of Follicular Variant of Papillary Thyroid Carcinoma in Fine‐Needle Aspiration Biopsy. Diagnostic Cytopathology, 29, 262-266. [Google Scholar] [CrossRef] [PubMed]
[18] Fakhar, Y., Khooei, A., Aghaee, A., Mohammadzadeh Kosari, H., Wartofsky, L. and Zakavi, S.R. (2021) Bone Metastasis from Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP); a Case Report. BMC Endocrine Disorders, 21, Article No. 221. [Google Scholar] [CrossRef] [PubMed]

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