儿童发热待查的病因诊断相关研究
Research on Etiological Diagnosis of Fever of Unknown Origin in Children
DOI: 10.12677/acm.2025.152556, PDF,   
作者: 郭 焱, 许红梅*：重庆医科大学附属儿童医院感染科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿童感染与免疫罕见病重庆市重点实验室，重庆
关键词: 儿童；发热待查；病因诊断；Children； Fever of Unknown Origin； Etiological Diagnosis
摘要: 发热待查(fever of unknown origin, FUO)是在儿童中较为常见的一种疾病，由于其病因种类繁多，且临床表现多种多样，使其在临床诊治中面临挑战。本文综述了国内外相关文献，梳理了病史、临床症状、体征及辅助检查结果与FUO病因的关系，旨在为临床医生在儿童FUO的诊断和治疗中提供思路，帮助制定全面合理的诊疗方案。
Abstract: Fever of unknown origin (FUO) is a common disease in children. Due to the variety of causes and clinical manifestations, FUO is a challenge in clinical diagnosis and treatment. This article reviewed relevant literature at home and abroad, and sorted out the relationship between the medical history, clinical symptoms, signs and auxiliary examination results and the etiology of FUO, aiming to provide clinicians with ideas in the diagnosis and treatment of FUO in children, and help formulate a comprehensive and reasonable diagnosis and treatment plan.
文章引用：郭焱, 许红梅. 儿童发热待查的病因诊断相关研究[J]. 临床医学进展, 2025, 15(2): 1958-1964. https://doi.org/10.12677/acm.2025.152556

参考文献

[1] 《中华传染病杂志》编辑委员会. 发热待查诊治专家共识[J]. 中华传染病杂志, 2017, 35(11): 641-655.
[2] Petersdorf, R.G. and Beeson, P.B. (1961) Fever of Unexplained Origin: Report on 100 Cases. Medicine, 40, 1-30. [Google Scholar] [CrossRef] [PubMed]
[3] 王有天, 申昆玲, 沈颖, 主编. 诸福棠实用儿科学[M]. 第9版. 北京: 人民卫生出版社, 2022: 473-476.
[4] Wright, W.F. and Auwaerter, P.G. (2020) Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma. Open Forum Infectious Diseases, 7, ofaa132. [Google Scholar] [CrossRef] [PubMed]
[5] Hu, B., Chen, T., Liu, S., Hu, H., Guo, L., Chen, H., et al. (2022) Fever of Unknown Origin (FUO) in Children: A Single-Centre Experience from Beijing, China. BMJ Open, 12, e049840. [Google Scholar] [CrossRef] [PubMed]
[6] Attard, L., Tadolini, M., De Rose, D.U., et al. (2018) Overview of Fever of Unknown Origin in Adult and Paediatric Patients. Clinical and Experimental Rheumatology, 36, 10-24.
[7] Chien, Y.L., Huang, F.L., Huang, C.M. and Chen, P.Y. (2017) Clinical Approach to Fever of Unknown Origin in Children. Journal of Microbiology, Immunology and Infection, 50, 893-898.
[8] Yachie, A. (2022) Clinical Perspectives and Therapeutic Strategies: Pediatric Autoinflammatory Disease—A Multi-Faceted Approach to Fever of Unknown Origin of Childhood. Inflammation and Regeneration, 42, Article No. 21. [Google Scholar] [CrossRef] [PubMed]
[9] Chow, A. and Robinson, J.L. (2010) Fever of Unknown Origin in Children: A Systematic Review. World Journal of Pediatrics, 7, 5-10. [Google Scholar] [CrossRef] [PubMed]
[10] 周毅虹, 唐兰芬, 敖当, 苏赞彩, 许逢明. 儿童不明原因发热137例临床分析[J]. 实用临床医学, 2004(3): 86-88.
[11] 张斌, 张晓洁. 100例儿童发热待查的临床分析[J]. 中国小儿急救医学, 2005, 12(6): 489-491.
[12] 徐祥新. 儿童不明原因长期发热58例病因分析[J]. 临床医药实践, 2009, 18(35): 2252-2253.
[13] 徐君, 叶颖子, 叶丽静, 等. 儿童不明原因发热357例病因及临床特征分析[J]. 中华儿科杂志, 2022, 60(1): 41-45.
[14] 涂俊才, 周平, 等. 500例不明原因发热患者临床病因分析[J]. 中国医学科学院报, 2013, 37(3): 348-315.
[15] Alexander, T. and Hedrich, C.M. (2022) Systemic Lupus Erythematosus—Are Children Miniature Adults? Clinical Immunology, 234, Article ID: 108907. [Google Scholar] [CrossRef] [PubMed]
[16] Kaul, A., Gordon, C., Crow, M.K., Touma, Z., Urowitz, M.B., van Vollenhoven, R., et al. (2016) Systemic Lupus Erythematosus. Nature Reviews Disease Primers, 2, Article No. 16039. [Google Scholar] [CrossRef] [PubMed]
[17] Giani, T., Smith, E.M., Al-Abadi, E., Armon, K., Bailey, K., Ciurtin, C., et al. (2021) Neuropsychiatric Involvement in Juvenile-Onset Systemic Lupus Erythematosus: Data from the UK Juvenile-Onset Systemic Lupus Erythematosus Cohort Study. Lupus, 30, 1955-1965. [Google Scholar] [CrossRef] [PubMed]
[18] 邵彩林, 于竞, 吉训超, . 189例儿童不明原因发热临床特征回顾性分析[J]. 中国病案, 2023(4): 102-105.
[19] 翟盼盼, 陆坚. 近10年中文文献报道的不明原因发热病例病因分析[J]. 新发传染病电子杂志, 2018, 3(4): 221-224.
[20] 马乐, 许庆梅, 陆天明. 儿童发热待查的相关研究[J]. 世界最新医学信息文摘, 2017, 17(52): 133, 139.
[21] Lieberman, J.M. (2009) North American Zoonoses. Pediatric Annals, 38, 193-198. [Google Scholar] [CrossRef] [PubMed]
[22] Statler, V.A. and Marshall, G.S. (2018) Evaluation of Prolonged and Recurrent Unexplained Fevers. Pediatric Annals, 47, e347-e353. [Google Scholar] [CrossRef] [PubMed]
[23] Trapani, S., Fiordelisi, A., Stinco, M. and Resti, M. (2023) Update on Fever of Unknown Origin in Children: Focus on Etiologies and Clinical Approach. Children, 11, Article No. 20. [Google Scholar] [CrossRef] [PubMed]
[24] Cleland, D.A. and Eranki, A.P. (2024) Procalcitonin. StatPearls Publishing.
[25] Aabenhus, R. and Jensen, J.S. (2011) Procalcitonin-Guided Antibiotic Treatment of Respiratory Tract Infections in a Primary Care Setting: Are We There Yet? Primary Care Respiratory Journal, 20, 360-367. [Google Scholar] [CrossRef] [PubMed]
[26] Otrock, Z.K., Hock, K.G., Riley, S.B., de Witte, T., Eby, C.S. and Scott, M.G. (2017) Elevated Serum Ferritin Is Not Specific for Hemophagocytic Lymphohistiocytosis. Annals of Hematology, 96, 1667-1672. [Google Scholar] [CrossRef] [PubMed]
[27] 中华医学会结核病学分会. 结核分枝杆菌γ-干扰素释放试验及临床应用专家意见(2021年版) [J]. 中华结核和呼吸杂志, 2022, 45(2): 143-150.
[28] 张丽丽, 乔森. 不明原因发热儿童血清检测EBV-CA-IgM的临床分析[J]. 临床医药文献电子杂志, 2018, 5(49): 3-4.
[29] 王梦荧. 宏基因组二代测序技术在儿童不明原因发热中的应用价值[D]: [硕士学位论文]. 衡阳: 南华大学, 2021.
[30] Ropers, F.G., van Mossevelde, R.M.P., Bleeker-Rovers, C.P., van Velden, F.H.P., van Assema, D.M.E., Adam, J.A., et al. (2020) Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation. Diagnostics, 10, Article No. 715. [Google Scholar] [CrossRef] [PubMed]
[31] Kouijzer, I.J.E., Mulders-Manders, C.M., Bleeker-Rovers, C.P. and Oyen, W.J.G. (2018) Fever of Unknown Origin: The Value of FDG-PET/CT. Seminars in Nuclear Medicine, 48, 100-107. [Google Scholar] [CrossRef] [PubMed]
[32] Dayal, R. and Agarwal, D. (2015) Fever in Children and Fever of Unknown Origin. The Indian Journal of Pediatrics, 83, 38-43. [Google Scholar] [CrossRef] [PubMed]

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