1例纵膈卵黄囊瘤并肺转移报道
Report of a Case of Mediastinal Yolk Sac Tumor with Lung Metastasis
DOI: 10.12677/acm.2025.153581, PDF,   
作者: 胡 彭：西南医科大学附属中医医院肿瘤·血液病科，四川 泸州；梁俊杰：西南医科大学附属中医医院心血管内科，四川 泸州
关键词: 纵膈卵黄囊瘤；诊断；治疗；Mediastinal Yolk Sac Tumor； Diagnosis； Treatment
摘要: 卵黄囊瘤(Yolk Sac Tumor, YST)，又称为内胚窦瘤(Endodermal Sinus Tumor, EST)，是一种罕见的来源于原始生殖细胞的恶性肿瘤(Germ Cell Tumor, GCT)，归为非精原细胞瘤的一种。由于其分化程度低，增殖速度快，故在生殖细胞恶性肿瘤中恶性程度很高，预后差。本文通过回顾收治的1例纵膈卵黄囊瘤伴双肺多发转移的青年男性患者经标准方案化疗后仍迅速进展至死亡的诊治过程，为纵膈卵黄囊瘤肺转移的临床诊疗工作提供一些经验及思路。
Abstract: Yolk Sac Tumor (YST), also known as Endodermal Sinus Tumor (EST), is a rare malignant tumor derived from primitive Germ Cell Tumor (GCT), which is classified as a type of non-seminoma. Due to its low degree of differentiation and rapid proliferation, it has a high degree of malignancy and a poor prognosis in germ cell malignancies. This article reviews the diagnosis and treatment process of a young male patient with mediastinal yolk sac tumor with multiple metastases in both lungs who died rapidly after standard chemotherapy, so as to provide some experience and ideas for the clinical diagnosis and treatment of lung metastasis of mediastinal yolk sac tumor.
文章引用：胡彭, 梁俊杰. 1例纵膈卵黄囊瘤并肺转移报道[J]. 临床医学进展, 2025, 15(3): 23-28. https://doi.org/10.12677/acm.2025.153581

参考文献

[1] Geng, R., Zheng, Z., Lin, Y., Li, Y., Ge, G., Zhang, J., et al. (2020) Clinical Characteristics and Prognostic Factors of Male Yolk Sac Tumor: A Surveillance, Epidemiology, and End Results Program Study. World Journal of Urology, 39, 1211-1217. [Google Scholar] [CrossRef] [PubMed]
[2] 马义祥, 刘敬伟, 齐康, 等. 原发性纵隔卵黄囊瘤7例[J]. 北京大学学报(医学版), 2019, 51(6): 1091-1095.
[3] Chaudhry, I.U., Rahhal, M., Khurshid, I. and Mutairi, H. (2014) Radical Surgical Resection for Giant Primary Mediastinal Endodermal Sinus Tumour with Pulmonary Metastasis after Chemotherapy: Can Be Curative. BMJ Case Reports, 2014, bcr2014204662. [Google Scholar] [CrossRef] [PubMed]
[4] 陈爱萍, 丁宁, 李海, 等. 纵隔原发性内胚窦瘤3例临床病例分析与文献复习[J]. 临床与病理杂志, 2016, 36(10): 1517-1521.
[5] Soriano, P.K., Iqbal, M.F., Siddiqui, O.M., Wang, J.F. and Desai, M.R. (2017) Non-Seminomatous Germ Cell Tumor Presenting with Superior Vena Cava Syndrome. American Journal of Case Reports, 18, 902-907. [Google Scholar] [CrossRef] [PubMed]
[6] 贾坤, 余建群. 前纵隔巨大卵黄囊瘤伴肝转移1例[J]. 中国医学影像技术, 2018, 34(12): 1914.
[7] 李芳云, 唐秉航. 原发性纵隔卵黄囊瘤CT影像学诊断[J]. 医学影像学杂志, 2018, 28(3): 507-509.
[8] Saxman, S., Nichols, C.R., Williams, S.D., Loehrer, P.J. and Einhorn, L.H. (1991) Mediastinal Yolk Sac Tumor. The Journal of Thoracic and Cardiovascular Surgery, 102, 913-916. [Google Scholar] [CrossRef] 
[9] 许存宝, 苏春阳, 姚锡虎, 张峰顺, 王怡璇, 陈一峰. 原发性纵隔卵黄囊瘤4例并文献复习[J]. 诊断病理学杂志, 2024, 31(11): 1031-1036.
[10] Weissferdt, A., Kalhor, N., Rodriguez Canales, J., Fujimoto, J., Wistuba, I.I. and Moran, C.A. (2019) Primary Mediastinal Yolk Sac Tumors: An Immunohistochemical Analysis of 14 Cases. Applied Immunohistochemistry & Molecular Morphology, 27, 125-133. [Google Scholar] [CrossRef] [PubMed]
[11] Rodney, A.J., Tannir, N.M., Siefker-Radtke, A.O., Liu, P., Walsh, G.L., Millikan, R.E., et al. (2012) Survival Outcomes for Men with Mediastinal Germ-Cell Tumors: The University of Texas M. D. Anderson Cancer Center Experience. Urologic Oncology: Seminars and Original Investigations, 30, 879-885. [Google Scholar] [CrossRef] [PubMed]
[12] Kesler, K.A., Rieger, K.M., Ganjoo, K.N., Sharma, M., Fineberg, N.S., Einhorn, L.H., et al. (1999) Primary Mediastinal Nonseminomatous Germ Cell Tumors: The Influence of Postchemotherapy Pathology on Long-Term Survival after Surgery. The Journal of Thoracic and Cardiovascular Surgery, 118, 692-701. [Google Scholar] [CrossRef] [PubMed]
[13] 高雪涵. 原发性纵隔卵黄囊瘤(PMYST)的临床诊治及预后特点[D]: [硕士学位论文]. 北京: 北京协和医学院, 2022.
[14] 吴敏, 左春霞, 谢建兰, 等. 睾丸混合性生殖细胞肿瘤临床病理分析并文献复习[J]. 诊断病理学杂志, 2024, 31(12): 1136-1140.

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