肠道菌群的改变与结肠息肉相关性的研究进展
Research Progress on the Correlation between Changes in Intestinal Microbiota and Colon Polyps
DOI: 10.12677/acm.2025.153586, PDF,   
作者: 艾尔夏提·热合曼江, 雷 勇, 肉斯旦·图尔迪：乌鲁木齐市友谊医院普外科，新疆 乌鲁木齐
关键词: 肠道菌群；结肠息肉；肥胖症；Gut Microbe； Colonic Polyp； Obesity
摘要: 肠道微生物一直被认为是机体的“隐形器官”，在维护人类健康方面发挥着不可替代的功能。近年的研究发现，肠道微生态与各种疾病之间存在一定的相关性，而肠道微生态与结肠息肉之间的相关性是目前研究的热点。结肠息肉是一种常见的消化道疾病，其发病率逐年升高。它不仅会对病人的肠道功能造成损害，而且某些息肉还会发生恶性转化，对人体健康构成极大的危害。而肠道微生物是机体多种生理活动的关键成分，一旦其失衡，即微生态失衡，将引起一系列肠道甚至整个机体的病理生理改变。
Abstract: Gut microbes have long been considered the “invisible organs” of the body and play an irreplaceable function in maintaining human health. Recent studies have found some correlation between intestinal microecology and various diseases, and the correlation between intestinal microecology and colon polyps is a current research hotspot. Colonic polyps are a common digestive tract disease, and their incidence increases year by year. It will not only cause damage to the patient’s intestinal function, but also cause some polyps to undergo malignant transformation, posing great harm to human health. Intestinal microbes are the key components of various physiological activities of the body. Once they are unbalanced, that is, the microecological imbalance, it will cause a series of pathophysiological changes in the intestinal tract and even the whole body.
文章引用：艾尔夏提·热合曼江, 雷勇, 肉斯旦·图尔迪. 肠道菌群的改变与结肠息肉相关性的研究进展[J]. 临床医学进展, 2025, 15(3): 56-61. https://doi.org/10.12677/acm.2025.153586

参考文献

[1] Valdes, A.M., Walter, J., Segal, E. and Spector, T.D. (2018) Role of the Gut Microbiota in Nutrition and Health. British Medical Journal, 361, k2179. [Google Scholar] [CrossRef] [PubMed]
[2] Keku, T.O., Dulal, S., Deveaux, A., Jovov, B. and Han, X. (2015) The Gastrointestinal Microbiota and Colorectal Cancer. American Journal of Physiology-Gastrointestinal and Liver Physiology, 308, G351-G363. [Google Scholar] [CrossRef] [PubMed]
[3] Wu, G., Xu, T., Zhao, N., Lam, Y.Y., Ding, X., Wei, D., et al. (2024) A Core Microbiome Signature as an Indicator of Health. Cell, 187, 6550-6565.e11. [Google Scholar] [CrossRef] [PubMed]
[4] 张静, 王肖枭, 周怡, 等. 肠道菌群与疾病相关性的研究进展[J]. 基础医学与临床, 2020, 40(2): 243-247.
[5] Stephens, R.W., Arhire, L. and Covasa, M. (2018) Gut Microbiota: From Microorganisms to Metabolic Organ Influencing Obesity. Obesity, 26, 801-809. [Google Scholar] [CrossRef] [PubMed]
[6] Campbell, C., Kandalgaonkar, M.R., Golonka, R.M., Yeoh, B.S., Vijay-Kumar, M. and Saha, P. (2023) Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy. Biomedicines, 11, Article 294. [Google Scholar] [CrossRef] [PubMed]
[7] 辜柏源, 丁永年. 结直肠息肉相关危险因素研究现状[J]. 齐齐哈尔医学院学报, 2024, 45(14): 1382-1386.
[8] Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K.S., Manichanh, C., et al. (2010) A Human Gut Microbial Gene Catalogue Established by Metagenomic Sequencing. Nature, 464, 59-65. [Google Scholar] [CrossRef] [PubMed]
[9] Chen, Y., Zhou, J. and Wang, L. (2021) Role and Mechanism of Gut Microbiota in Human Disease. Frontiers in Cellular and Infection Microbiology, 11, Article 625913. [Google Scholar] [CrossRef] [PubMed]
[10] 李惠, 赵菊梅, 师长宏. 基于肠道菌群的免疫调节策略用于结直肠癌联合治疗研究的进展[J]. 中国实验动物学报, 2022, 30(3): 436-443.
[11] Sun, T., Liu, S., Zhou, Y., Yao, Z., Zhang, D., Cao, S., et al. (2016) Evolutionary Biologic Changes of Gut Microbiota in an ‘Adenoma-Carcinoma Sequence’ Mouse Colorectal Cancer Model Induced by 1, 2-Dimethylhydrazine. Oncotarget, 8, 444-457. [Google Scholar] [CrossRef] [PubMed]
[12] Hale, V.L., Chen, J., Johnson, S., Harrington, S.C., Yab, T.C., Smyrk, T.C., et al. (2017) Shifts in the Fecal Microbiota Associated with Adenomatous Polyps. Cancer Epidemiology, Biomarkers & Prevention, 26, 85-94. [Google Scholar] [CrossRef] [PubMed]
[13] Zhang, Z., Tang, H., Chen, P., Xie, H. and Tao, Y. (2019) Demystifying the Manipulation of Host Immunity, Metabolism, and Extraintestinal Tumors by the Gut Microbiome. Signal Transduction and Targeted Therapy, 4, Article No. 41. [Google Scholar] [CrossRef] [PubMed]
[14] 徐艳丽, 尹霞, 常英. 肠道菌群失衡在结直肠癌发病过程中的作用[J]. 国际消化病杂志, 2014, 34(2): 124-127.
[15] 陈辞言, 杜艳. 肠道菌群及其代谢产物与结肠腺瘤性息肉相关性的研究进展[J]. 中国微生态学杂志, 2019, 31(9): 1092-1096.
[16] Huyghe, J.R., Bien, S.A., Harrison, T.A., Kang, H.M., Chen, S., Schmit, S.L., et al. (2018) Discovery of Common and Rare Genetic Risk Variants for Colorectal Cancer. Nature Genetics, 51, 76-87. [Google Scholar] [CrossRef] [PubMed]
[17] Qu, R., Zhang, Y., Ma, Y., Zhou, X., Sun, L., Jiang, C., et al. (2023) Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer. Advanced Science, 10, Article 2205563. [Google Scholar] [CrossRef] [PubMed]
[18] DeGruttola, A.K., Low, D., Mizoguchi, A. and Mizoguchi, E. (2016) Current Understanding of Dysbiosis in Disease in Human and Animal Models. Inflammatory Bowel Diseases, 22, 1137-1150. [Google Scholar] [CrossRef] [PubMed]
[19] Cotillard, A., Kennedy, S.P., Kong, L.C., Prifti, E., Pons, N., Le Chatelier, E., et al. (2013) Dietary Intervention Impact on Gut Microbial Gene Richness. Nature, 500, 585-588. [Google Scholar] [CrossRef] [PubMed]
[20] Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D.R., et al. (2011) Enterotypes of the Human Gut Microbiome. Nature, 473, 174-180. [Google Scholar] [CrossRef] [PubMed]
[21] Goedert, J.J., Gong, Y., Hua, X., Zhong, H., He, Y., Peng, P., et al. (2015) Fecal Microbiota Characteristics of Patients with Colorectal Adenoma Detected by Screening: A Population-Based Study. EBioMedicine, 2, 597-603. [Google Scholar] [CrossRef] [PubMed]
[22] Hussan, H., Clinton, S.K., Roberts, K. and Bailey, M.T. (2017) fusobacterium’s Link to Colorectal Neoplasia Sequenced: A Systematic Review and Future Insights. World Journal of Gastroenterology, 23, 8626-8650. [Google Scholar] [CrossRef] [PubMed]
[23] Guo, S., Li, L., Xu, B., Li, M., Zeng, Q., Xiao, H., et al. (2018) A Simple and Novel Fecal Biomarker for Colorectal Cancer: Ratio of Fusobacterium Nucleatum to Probiotics Populations, Based on Their Antagonistic Effect. Clinical Chemistry, 64, 1327-1337. [Google Scholar] [CrossRef] [PubMed]
[24] Kim, M., Vogtmann, E., Ahlquist, D.A., Devens, M.E., Kisiel, J.B., Taylor, W.R., et al. (2020) Fecal Metabolomic Signatures in Colorectal Adenoma Patients Are Associated with Gut Microbiota and Early Events of Colorectal Cancer Pathogenesis. mBio, 11, 16. [Google Scholar] [CrossRef] [PubMed]
[25] Saeed, M., Shoaib, A., Kandimalla, R., Javed, S., Almatroudi, A., Gupta, R., et al. (2022) Microbe-Based Therapies for Colorectal Cancer: Advantages and Limitations. Seminars in Cancer Biology, 86, 652-665. [Google Scholar] [CrossRef] [PubMed]
[26] Lou, Y., Song, M., Han, M., Zhong, J., Tian, X., Ren, Y., et al. (2022) Tumor Necrosis Factor-Α-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer. Cancer Immunology Research, 10, 354-367. [Google Scholar] [CrossRef] [PubMed]
[27] Peters, B.A., Dominianni, C., Shapiro, J.A., Church, T.R., Wu, J., Miller, G., et al. (2016) The Gut Microbiota in Conventional and Serrated Precursors of Colorectal Cancer. Microbiome, 4, Article No. 69. [Google Scholar] [CrossRef] [PubMed]
[28] Watson, K.M., Gardner, I.H., Anand, S., Siemens, K.N., Sharpton, T.J., Kasschau, K.D., et al. (2021) Colonic Microbial Abundances Predict Adenoma Formers. Annals of Surgery, 277, e817-e824. [Google Scholar] [CrossRef] [PubMed]
[29] 尹莉莉. 菌群失调参与远端结直肠息肉复发的机制研究[D]: [硕士学位论文]. 南昌: 南昌大学, 2024.
[30] Li, J., Zhu, Y., Yang, L. and Wang, Z. (2022) Effect of Gut Microbiota in the Colorectal Cancer and Potential Target Therapy. Discover Oncology, 13, Article No. 51. [Google Scholar] [CrossRef] [PubMed]
[31] Barna, I., Nyúl, D., Szentes, T. and Schwab, R. (2018) A bélmikrobiom, a metabolikus betegségek és a hypertonia kapcsolatának irodalmi áttekintése. Orvosi Hetilap, 159, 346-351. [Google Scholar] [CrossRef] [PubMed]
[32] Pop, O.L., Vodnar, D.C., Diaconeasa, Z., Istrati, M., Bințințan, A., Bințințan, V.V., et al. (2020) An Overview of Gut Microbiota and Colon Diseases with a Focus on Adenomatous Colon Polyps. International Journal of Molecular Sciences, 21, Article 7359. [Google Scholar] [CrossRef] [PubMed]
[33] Jass, J.R. (2006) Classification of Colorectal Cancer Based on Correlation of Clinical, Morphological and Molecular Features. Histopathology, 50, 113-130. [Google Scholar] [CrossRef] [PubMed]
[34] Hu, H., Gong, X., Xu, K., Luo, S., Gao, W., Li, B., et al. (2023) Risk Factor Analysis of Malignant Adenomas Detected during Colonoscopy. Frontiers in Medicine, 10, Article 1106272. [Google Scholar] [CrossRef] [PubMed]
[35] Burrows, M.P., Volchkov, P., Kobayashi, K.S. and Chervonsky, A.V. (2015) Microbiota Regulates Type 1 Diabetes through Toll-Like Receptors. Proceedings of the National Academy of Sciences, 112, 9973-9977. [Google Scholar] [CrossRef] [PubMed]
[36] 杨丽萍, 马臻棋, 王学红, 等. 肠道菌群与结肠息肉的关系研究进展[J]. 中国医刊, 2022, 57(2): 139-141.
[37] Gao, M., Zhong, A., Patel, N., Alur, C. and Vyas, D. (2017) High Throughput RNA Sequencing Utility for Diagnosis and Prognosis in Colon Diseases. World Journal of Gastroenterology, 23, 2819-2825. [Google Scholar] [CrossRef] [PubMed]
[38] Rezasoltani, S., Ghanbari, R., Looha, M.A., Mojarad, E.N., Yadegar, A., Stewart, D., et al. (2020) Expression of Main Toll-Like Receptors in Patients with Different Types of Colorectal Polyps and Their Relationship with Gut Microbiota. International Journal of Molecular Sciences, 21, Article 8968. [Google Scholar] [CrossRef] [PubMed]
[39] Dai, Z., Zhang, J., Wu, Q., Chen, J., Liu, J., Wang, L., et al. (2019) The Role of Microbiota in the Development of Colorectal Cancer. International Journal of Cancer, 145, 2032-2041. [Google Scholar] [CrossRef] [PubMed]
[40] Brennan, C.A. and Garrett, W.S. (2016) Gut Microbiota, Inflammation, and Colorectal Cancer. Annual Review of Microbiology, 70, 395-411. [Google Scholar] [CrossRef] [PubMed]
[41] Morrison, D.J. and Preston, T. (2016) Formation of Short Chain Fatty Acids by the Gut Microbiota and Their Impact on Human Metabolism. Gut Microbes, 7, 189-200. [Google Scholar] [CrossRef] [PubMed]
[42] Tailford, L.E., Crost, E.H., Kavanaugh, D. and Juge, N. (2015) Mucin Glycan Foraging in the Human Gut Microbiome. Frontiers in Genetics, 6, Article 81. [Google Scholar] [CrossRef] [PubMed]
[43] Oh, T.J., Sul, W.J., Oh, H.N., Lee, Y., Lim, H.L., Choi, S.H., et al. (2019) Butyrate Attenuated Fat Gain through Gut Microbiota Modulation in Db/Db Mice Following Dapagliflozin Treatment. Scientific Reports, 9, Article No. 20300. [Google Scholar] [CrossRef] [PubMed]
[44] Abu-Ghazaleh, N., Chua, W.J. and Gopalan, V. (2020) Intestinal Microbiota and Its Association with Colon Cancer and Red/Processed Meat Consumption. Journal of Gastroenterology and Hepatology, 36, 75-88. [Google Scholar] [CrossRef] [PubMed]
[45] Elinav, E., Strowig, T., Kau, A.L., Henao-Mejia, J., Thaiss, C.A., Booth, C.J., et al. (2011) NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis. Cell, 145, 745-757. [Google Scholar] [CrossRef] [PubMed]
[46] Bonder, M.J., Kurilshikov, A., Tigchelaar, E.F., Mujagic, Z., Imhann, F., Vila, A.V., et al. (2016) The Effect of Host Genetics on the Gut Microbiome. Nature Genetics, 48, 1407-1412. [Google Scholar] [CrossRef] [PubMed]
[47] Cremon, C., Barbaro, M.R., Ventura, M. and Barbara, G. (2018) Pre and Probiotic Overview. Current Opinion in Pharmacology, 43, 87-92. [Google Scholar] [CrossRef] [PubMed]

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