影响乳腺癌复发的宿主相关因素研究进展
Research Progress on Host-Related Factors Affecting Breast Cancer Recurrence
DOI: 10.12677/acm.2025.153604, PDF,    科研立项经费支持
作者: 朱志博, 董亚玲:甘肃中医药大学第一临床医学院,甘肃 兰州;中国人民解放军联勤保障部队第九四〇医院肿瘤科,甘肃 兰州;马澜婧*, 曾伟华, 张百红*:中国人民解放军联勤保障部队第九四〇医院肿瘤科,甘肃 兰州
关键词: 乳腺癌休眠复发炎症肥胖饮食体力活动情绪障碍Breast Cancer Dormancy Recurrence Inflammation Obesity Diet Physical Activity Emotional Disorder
摘要: 肿瘤复发是乳腺癌相关死亡的主要原因。靶向可改变的风险因素以降低乳腺癌复发率是新的研究热点。本综述介绍了影响乳腺癌复发的宿主相关因素的最新发现,目的是为临床医生提供乳腺癌全程管理的新思路,引导他们进一步关注可能改善乳腺癌预后的全方位临床干预措施。
Abstract: Tumor recurrence is the main cause of breast cancer-related death. Targeting modifiable risk factors to reduce breast cancer recurrence rate has become a new research hotspot. In this review, we illustrate the latest discoveries on host-related factors that may influence the recurrence of breast cancer. The aim of this review is to offer clinicians recent insights into breast cancer whole process management and further guide them to focus on the complete clinical intervention measures that might improve breast cancer prognosis.
文章引用:朱志博, 马澜婧, 董亚玲, 曾伟华, 张百红. 影响乳腺癌复发的宿主相关因素研究进展[J]. 临床医学进展, 2025, 15(3): 192-199. https://doi.org/10.12677/acm.2025.153604

参考文献

[1] Giaquinto, A.N., Sung, H., Miller, K.D., et al. (2022) Breast Cancer Statistics, 2022. CA: A Cancer Journal for Clinicians, 72, 524-541. [Google Scholar] [CrossRef] [PubMed]
[2] Pedersen, R.N., Esen, B., Mellemkjær, L., et al. (2022) The Incidence of Breast Cancer Recurrence 10-32 Years after Primary Diagnosis. Journal of the National Cancer Institute, 114, 391-399. [Google Scholar] [CrossRef] [PubMed]
[3] Riggio, A.I., Varley, K.E. and Welm, A.L. (2021) The Lingering Mysteries of Metastatic Recurrence in Breast Cancer. British Journal of Cancer, 124, 13-26. [Google Scholar] [CrossRef] [PubMed]
[4] Jahangiri, L. and Ishola, T. (2022) Dormancy in Breast Cancer, the Role of Autophagy, lncRNAs, miRNAs and Exosomes. International Journal of Molecular Sciences, 23, Article 5271. [Google Scholar] [CrossRef] [PubMed]
[5] Tamamouna, V., Pavlou, E., Neophytou, C.M., et al. (2022) Regulation of Metastatic Tumor Dormancy and Emerging Opportunities for Therapeutic Intervention. International Journal of Molecular Sciences, 23, Article 13931. [Google Scholar] [CrossRef] [PubMed]
[6] Clark, A.M., Wheeler, S.E., Young, C.L., et al. (2017) A Liver Microphysiological System of Tumor Cell Dormancy and Inflammatory Responsiveness Is Affected by Scaffold Properties. Lab on a Chip, 17, 156-168. [Google Scholar] [CrossRef
[7] Khazali, A.S., Clark, A.M. and Wells, A. (2018) Inflammatory Cytokine IL-8/CXCL8 Promotes Tumour Escape from Hepatocyte-Induced Dormancy. British Journal of Cancer, 118, 566-576. [Google Scholar] [CrossRef] [PubMed]
[8] Correia, A.L., Guimaraes, J.C., Auf Der Maur, P., et al. (2021) Hepatic Stellate Cells Suppress NK Cell-Sustained Breast Cancer Dormancy. Nature, 594, 566-571. [Google Scholar] [CrossRef] [PubMed]
[9] Albrengues, J., Shields, M.A., Ng, D., et al. (2018) Neutrophil Extracellular Traps Produced during Inflammation Awaken Dormant Cancer Cells in Mice. Science, 361, eaao4227. [Google Scholar] [CrossRef] [PubMed]
[10] Krall, J.A., Reinhardt, F., Mercury, O.A., et al. (2018) The Systemic Response to Surgery Triggers the Outgrowth of Distant Immune-Controlled Tumors in Mouse Models of Dormancy. Science Translational Medicine, 10, eaan3464. [Google Scholar] [CrossRef] [PubMed]
[11] Haldar, R., Berger, L.S., Rossenne, E., et al. (2023) Perioperative Escape from Dormancy of Spontaneous Micro-Metastases: A Role for Malignant Secretion of IL-6, IL-8, and VEGF, through Adrenergic and Prostaglandin Signaling. Brain, Behavior, and Immunity, 109, 175-187. [Google Scholar] [CrossRef] [PubMed]
[12] Ricon, I., Hanalis-Miller, T., Haldar, R., et al. (2019) Perioperative Biobehavioral Interventions to Prevent Cancer Recurrence through Combined Inhibition of β-Adrenergic and Cyclooxygenase 2 Signaling. Cancer, 125, 45-56. [Google Scholar] [CrossRef] [PubMed]
[13] Shaashua, L., Shabat-Simon, M., Haldar, R., et al. (2017) Perioperative COX-2 and β-Adrenergic Blockade Improves Metastatic Biomarkers in Breast Cancer Patients in a Phase-II Randomized Trial. Clinical Cancer Research, 23, 4651-4661. [Google Scholar] [CrossRef
[14] Desmedt, C., Demicheli, R., Fornili, M., et al. (2018) Potential Benefit of Intra-Operative Administration of Ketorolac on Breast Cancer Recurrence according to the Patient’s Body Mass Index. JNCI: Journal of the National Cancer Institute, 110, 1115-1122. [Google Scholar] [CrossRef] [PubMed]
[15] Pannu, M.K. and Constantinou, C. (2023) Inflammation, Nutrition, and Clinical Outcomes in Breast Cancer Survivors: A Narrative Review. Current Nutrition Reports, 12, 643-661. [Google Scholar] [CrossRef] [PubMed]
[16] Jang, H., Chung, M.S., Kang, S.S., et al. (2018) Association between the Dietary Inflammatory Index and Risk for Cancer Recurrence and Mortality among Patients with Breast Cancer. Nutrients, 10, Article 1095. [Google Scholar] [CrossRef] [PubMed]
[17] Castro-Espin, C. and Agudo, A. (2022) The Role of Diet in Prognosis among Cancer Survivors: A Systematic Review and Meta-Analysis of Dietary Patterns and Diet Interventions. Nutrients, 14, Article 348. [Google Scholar] [CrossRef] [PubMed]
[18] Wang, K., Sun, J.Z., Wu, Q.X., et al. (2020) Long-Term Anti-Inflammatory Diet in Relation to Improved Breast Cancer Prognosis: A Prospective Cohort Study. NPJ Breast Cancer, 6, Article No. 36. [Google Scholar] [CrossRef] [PubMed]
[19] Castro-Espin, C., Bonet, C., Crous-Bou, M., et al. (2023) Dietary Patterns Related to Biological Mechanisms and Survival after Breast Cancer Diagnosis: Results from a Cohort Study. British Journal of Cancer, 128, 1301-1310. [Google Scholar] [CrossRef] [PubMed]
[20] Mikkelsen, M.K., Lindblom, N.A.F., Dyhl-Polk, A., et al. (2022) Systematic Review and Meta-Analysis of C-Reactive Protein as a Biomarker in Breast Cancer. Critical Reviews in Clinical Laboratory Sciences, 59, 480-500. [Google Scholar] [CrossRef] [PubMed]
[21] Mcandrew, N.P., Bottalico, L., Mesaros, C., et al. (2021) Effects of Systemic Inflammation on Relapse in Early Breast Cancer. NPJ Breast Cancer, 7, Article No. 7. [Google Scholar] [CrossRef] [PubMed]
[22] Wu, T., Seaver, P., Lemus, H., et al. (2019) Associations between Dietary Acid Load and Biomarkers of Inflammation and Hyperglycemia in Breast Cancer Survivors. Nutrients, 11, Article 1913. [Google Scholar] [CrossRef] [PubMed]
[23] Kus, T., Cinkir, H.Y., Aktas, G., et al. (2019) Hepatosteatosis May Predict Late Recurrence of Breast Cancer: A Single-Center Observational Study. Current Problems in Cancer, 43, Article 100461. [Google Scholar] [CrossRef] [PubMed]
[24] Nechuta, S., Chen, W.Y., Cai, H., et al. (2016) A Pooled Analysis of Post-Diagnosis Lifestyle Factors in Association with Late Estrogen-Receptor—Positive Breast Cancer Prognosis. International Journal of Cancer, 138, 2088-2097. [Google Scholar] [CrossRef] [PubMed]
[25] Guo, Z., Wang, J., Tian, X., et al. (2022) Body Mass Index Increases the Recurrence Risk of Breast Cancer: A Dose-Response Meta-Analysis from 21 Prospective Cohort Studies. Public Health, 210, 26-33. [Google Scholar] [CrossRef] [PubMed]
[26] Biganzoli, E., Desmedt, C., Fornili, M., et al. (2017) Recurrence Dynamics of Breast Cancer according to Baseline Body Mass Index. European Journal of Cancer, 87, 10-20. [Google Scholar] [CrossRef] [PubMed]
[27] Bonet, C., Crous-Bou, M., Tsilidis, K.K., et al. (2023) The Association between Body Fatness and Mortality among Breast Cancer Survivors: Results from a Prospective Cohort Study. European Journal of Epidemiology, 38, 545-557. [Google Scholar] [CrossRef] [PubMed]
[28] Ee, C., Cave, A.E., Naidoo, D., et al. (2020) Weight before and after a Diagnosis of Breast Cancer or Ductal Carcinoma in Situ: A National Australian Survey. BMC Cancer, 20, Article No. 113. [Google Scholar] [CrossRef] [PubMed]
[29] Basen-Engquist, K.M., Raber, M., Carmack, C.L., et al. (2020) Feasibility and Efficacy of a Weight Gain Prevention Intervention for Breast Cancer Patients Receiving Neoadjuvant Chemotherapy: A Randomized Controlled Pilot Study. Supportive Care in Cancer, 28, 5821-5832. [Google Scholar] [CrossRef] [PubMed]
[30] Iyengar, N.M., Gucalp, A., Dannenberg, A.J., et al. (2016) Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation. Journal of Clinical Oncology, 34, 4270-4276. [Google Scholar] [CrossRef
[31] Quail, D.F., Olson, O.C., Bhardwaj, P., et al. (2017) Obesity Alters the Lung Myeloid Cell Landscape to Enhance Breast Cancer Metastasis through IL5 and GM-CSF. Nature Cell Biology, 19, 974-987. [Google Scholar] [CrossRef] [PubMed]
[32] Altea-Manzano, P., Doglioni, G., Liu, Y., et al. (2023) A Palmitate-Rich Metastatic Niche Enables Metastasis Growth via p65 Acetylation Resulting in PRO-Metastatic NF-κB Signaling. Nature Cancer, 4, 344-364. [Google Scholar] [CrossRef] [PubMed]
[33] Ecker, B.L., Lee, J.Y., Sterner, C.J., et al. (2019) Impact of Obesity on Breast Cancer Recurrence and Minimal Residual Disease. Breast Cancer Research, 21, Article No. 41. [Google Scholar] [CrossRef] [PubMed]
[34] Roy, R., Yang, J., Shimura, T., et al. (2022) Escape from Breast Tumor Dormancy: The Convergence of Obesity and Menopause. Applied Biological Sciences, 119, e2204758119. [Google Scholar] [CrossRef] [PubMed]
[35] Berrino, F., Villarini, A., Gargano, G., et al. (2023) The Effect of Diet on Breast Cancer Recurrence: The DIANA-5 Randomized Trial. Clinical Cancer Research, 30, 965-974. [Google Scholar] [CrossRef
[36] Di Maso, M., Dal Maso, L., Augustin, L.S.A., et al. (2020) Adherence to the Mediterranean Diet and Mortality after Breast Cancer. Nutrients, 12, Article 3649. [Google Scholar] [CrossRef] [PubMed]
[37] Castro-Espin, C., Bonet, C., Crous-Bou, M., et al. (2023) Association of Mediterranean Diet with Survival after Breast Cancer Diagnosis in Women from Nine European Countries: Results from the EPIC Cohort Study. BMC Medicine, 21, Article No. 225. [Google Scholar] [CrossRef] [PubMed]
[38] Chen, G., Leary, S., Niu, J., et al. (2023) The Role of the Mediterranean Diet in Breast Cancer Survivorship: A Systematic Review and Meta-Analysis of Observational Studies and Randomised Controlled Trials. Nutrients, 15, Article 2099. [Google Scholar] [CrossRef] [PubMed]
[39] Flore, G., Deledda, A., Lombardo, M., et al. (2023) Effects of Functional and Nutraceutical Foods in the Context of the Mediterranean Diet in Patients Diagnosed with Breast Cancer. Antioxidants, 12, Article 1845. [Google Scholar] [CrossRef] [PubMed]
[40] Merra, G., Noce, A., Marrone, G., et al. (2021) Influence of Mediterranean Diet on Human Gut Microbiota. Nutrients, 13, Article 7. [Google Scholar] [CrossRef] [PubMed]
[41] Schwingshackl, L., Morze, J. and Hoffmann, G. (2020) Mediterranean Diet and Health Status: Active Ingredients and Pharmacological Mechanisms. British Journal of Pharmacology, 177, 1241-1257. [Google Scholar] [CrossRef] [PubMed]
[42] Martínez, N., Herrera, M., Frías, L., et al. (2019) A Combination of Hydroxytyrosol, Omega-3 Fatty Acids and Curcumin Improves Pain and Inflammation among Early Stage Breast Cancer Patients Receiving Adjuvant Hormonal Therapy: Results of a Pilot Study. Clinical and Translational Oncology, 21, 489-498. [Google Scholar] [CrossRef] [PubMed]
[43] Foroutan-Ghaznavi, M., Mazloomi, S.M., Montazeri, V., et al. (2022) Dietary Patterns in Association with the Expression of Pro-Metastatic Genes in Primary Breast Cancer. European Journal of Nutrition, 61, 3267-3284. [Google Scholar] [CrossRef] [PubMed]
[44] Spei, M.E., Bellos, I., Samoli, E., et al. (2023) Post-Diagnosis Dietary Patterns among Cancer Survivors in Relation to All-Cause Mortality and Cancer-Specific Mortality: A Systematic Review and Meta-Analysis of Cohort Studies. Nutrients, 15, Article 3860. [Google Scholar] [CrossRef] [PubMed]
[45] Wang, F., Cai, H., Gu, K., et al. (2020) Adherence to Dietary Recommendations among Long-Term Breast Cancer Survivors and Cancer Outcome Associations. Cancer Epidemiology, Biomarkers & Prevention, 29, 386-395. [Google Scholar] [CrossRef
[46] Vernieri, C., Ligorio, F., Zattarin, E., et al. (2020) Fasting-Mimicking Diet Plus Chemotherapy in Breast Cancer Treatment. Nature Communications, 11, Article No. 4274. [Google Scholar] [CrossRef] [PubMed]
[47] Jia, T., Liu, Y., Fan, Y., et al. (2022) Association of Healthy Diet and Physical Activity with Breast Cancer: Lifestyle Interventions and Oncology Education. Frontiers in Public Health, 10, Article 797794. [Google Scholar] [CrossRef] [PubMed]
[48] Rock, C.L., Thomson, C., Gansler, T., et al. (2020) American Cancer Society Guideline for Diet and Physical Activity for Cancer Prevention. A Cancer Journal for Clinicians, 70, 245-271. [Google Scholar] [CrossRef] [PubMed]
[49] Morishita, S., Hamaue, Y., Fukushima, T., et al. (2020) Effect of Exercise on Mortality and Recurrence in Patients with Cancer: A Systematic Review and Meta-Analysis. Integrative Cancer Therapies, 19. [Google Scholar] [CrossRef] [PubMed]
[50] Lynch, B.M., Milne, R.L., English, D.R., et al. (2022) Linking Physical Activity to Breast Cancer: Text Mining Results and a Protocol for Systematically Reviewing Three Potential Mechanistic Pathways. Cancer Epidemiology, Biomarkers & Prevention, 31, 11-15. [Google Scholar] [CrossRef
[51] Sheinboim, D., Parikh, S., Manich, P., et al. (2022) An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination. Cancer Research, 82, 4164-4178. [Google Scholar] [CrossRef
[52] Pistelli, M., Natalucci, V., Scortichini, L., et al. (2021) The Impact of Lifestyle Interventions in High-Risk Early Breast Cancer Patients: A Modeling Approach from a Single Institution Experience. Cancers, 13, Article 5539. [Google Scholar] [CrossRef] [PubMed]
[53] Wang, Y., Song, H., Yin, Y., et al. (2019) Cancer Survivors Could Get Survival Benefits from Postdiagnosis Physical Activity: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine, 2019, Article 1940903. [Google Scholar] [CrossRef] [PubMed]
[54] Lee, J. (2019) A Meta-Analysis of the Association between Physical Activity and Breast Cancer Mortality. Cancer Nursing, 42, 271-285. [Google Scholar] [CrossRef
[55] Dethlefsen, C., Hansen, L.S., Lillelund, C., et al. (2017) Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development. Cancer Research, 77, 4894-4904. [Google Scholar] [CrossRef
[56] Zheng, A., Zhang, L., Yang, J., et al. (2022) Physical Activity Prevents Tumor Metastasis through Modulation of Immune Function. Frontiers in Pharmacology, 13, Article 1034129. [Google Scholar] [CrossRef] [PubMed]
[57] Wang, X., Wang, N., Zhong, L., et al. (2020) Prognostic Value of Depression and Anxiety on Breast Cancer Recurrence and Mortality: A Systematic Review and Meta-Analysis of 282,203 Patients. Molecular Psychiatry, 25, 3186-3197. [Google Scholar] [CrossRef] [PubMed]
[58] Yang, Y., Sun, H., Luo, X., et al. (2022) Network Connectivity between Fear of Cancer Recurrence, Anxiety, and Depression in Breast Cancer Patients. Journal of Affective Disorders, 309, 358-367. [Google Scholar] [CrossRef] [PubMed]
[59] Malgaroli, M., Szuhany, K.L., Riley, G., et al. (2023) Heterogeneity of Posttraumatic Stress, Depression, and Fear of Cancer Recurrence in Breast Cancer Survivors: A Latent Class Analysis. Journal of Cancer Survivorship, 17, 1510-1521. [Google Scholar] [CrossRef] [PubMed]
[60] Akechi, T., Yamaguchi, T., Uchida, M., et al. (2023) Smartphone Psychotherapy Reduces Fear of Cancer Recurrence among Breast Cancer Survivors: A Fully Decentralized Randomized Controlled Clinical Trial (J-SUPPORT 1703 Study). Journal of Clinical Oncology, 41, 1069-1078. [Google Scholar] [CrossRef