二甲双胍乳腺癌治疗的研究进展
Research Progress of Metformin in the Treatment of Breast Cancer
DOI: 10.12677/acm.2025.153608, PDF,    科研立项经费支持
作者: 李雪灵*, 古唐欣雨, 邓安妮, 赵 慧:西南医科大学儿科学系,四川 泸州;甘 淋#:西南医科大学基础医学院,四川 泸州
关键词: 二甲双胍乳腺癌抗肿瘤Metformin Breast Cancer Anti-Tumor
摘要: 二甲双胍(Metformin, Met)是治疗2型糖尿病的一线药物,同时具有抗肿瘤特性。体内外实验证实了二甲双胍对各亚型乳腺癌均有抑制作用,并且二甲双胍还能与其他化疗药物协同治疗乳腺癌。文章论述了Met抑制不同亚型乳腺癌的作用机制,并简要讨论将二甲双胍纳入临床治疗乳腺癌的未来前景。
Abstract: Metformin is a first-line drug for the treatment of type 2 diabetes and has anti-tumor properties. In vitro and in vivo experiments have confirmed that metformin has an inhibitory effect on all subtypes of breast cancer, and metformin can also cooperate with other chemotherapy drugs to treat breast cancer. This article discusses the mechanism of Met inhibiting different subtypes of breast cancer and briefly discusses the future prospect of incorporating metformin into the clinical treatment of breast cancer.
文章引用:李雪灵, 古唐欣雨, 邓安妮, 赵慧, 甘淋. 二甲双胍乳腺癌治疗的研究进展[J]. 临床医学进展, 2025, 15(3): 227-233. https://doi.org/10.12677/acm.2025.153608

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