基于铁死亡机制探讨防治动脉粥样硬化的研究进展
Research Progress on the Prevention and Treatment of Atherosclerosis Based on the Mechanism of Ferroptosis
DOI: 10.12677/acm.2025.153700, PDF,   
作者: 史振兴*：黑龙江中医药大学研究生院，黑龙江 哈尔滨；陈 鹏#：黑龙江中医药大学附属第一医院心血管病一科，黑龙江 哈尔滨
关键词: 铁死亡；动脉粥样硬化；巨噬细胞；泡沫细胞；Ferroptosis； Atherosclerosis； Macrophage； Foam Cell
摘要: 动脉粥样硬化是许多严重心血管疾病的基本病理状态，以脂代谢障碍为特征。铁死亡是一种新的程序性细胞死亡方式，主要由铁依赖性脂质过氧化物介导。铁死亡参与许多疾病的病理过程，包括癌症、创伤性脑损伤、神经退行性疾病以及多种心血管疾病。近年来，大量的研究表明铁死亡是动脉粥样硬化病变进展的关键因素，本文论述了铁死亡的机制以及铁死亡在血管内皮功能障碍、巨噬细胞极化、泡沫细胞形成、血管平滑肌增殖迁移等动脉粥样硬化病理过程中的作用，并总结了多种可以抑制铁死亡治疗动脉粥样硬化的相关研究进展，意在为以铁死亡为靶点的动脉粥样硬化的防治提供思路。
Abstract: Atherosclerosis is the underlying pathological state of many serious cardiovascular diseases and is characterized by impaired lipid metabolism. Ferroptosis is a new mode of programmed cell death mediated primarily by iron-dependent lipid peroxidation. Ferroptosis residues the pathologic processes of many diseases, including cancer, traumatic brain injury, neurodegenerative diseases, and many cardiovascular diseases. In recent years, a large number of studies have shown that ferroptosis is a key factor in the progression of atherosclerotic lesions. This article discusses the mechanism of ferroptosis and the role of ferroptosis in atherosclerotic pathological processes, such as vascular endothelial dysfunction, macrophage polarization, foam cell formation, and proliferation and migration of vascular smooth muscle. We also summarize the progress of various studies that can inhibit ferroptosis in the treatment of atherosclerosis, with the intention of providing ideas for the prevention and treatment of atherosclerosis targeting ferroptosis.
文章引用：史振兴, 陈鹏. 基于铁死亡机制探讨防治动脉粥样硬化的研究进展[J]. 临床医学进展, 2025, 15(3): 958-966. https://doi.org/10.12677/acm.2025.153700

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