肠道普氏菌属影响哮喘发生发展的机制研究进展
Research Progress on the Mechanism of Intestinal Prevotella Affecting the Occurrence and Development of Asthma
DOI: 10.12677/acm.2025.153711, PDF,   
作者: 刘 荟, 舒 畅*：重庆医科大学附属儿童医院呼吸科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿童感染与免疫罕见病重庆市重点实验室，重庆
关键词: 普雷沃氏菌属；哮喘；肠–肺轴；免疫调节；代谢调控；Prevotella； Asthma； Gut-Lung Axis； Immunomodulation； Metabolic Regulation
摘要: 哮喘(Asthma)是儿童时期常见的慢性呼吸系统疾病。近几十年来，我国儿童哮喘的患病率总体呈上升趋势，造成极大的疾病危害与经济负担，对哮喘病因、发病机制的研究有益于哮喘的预防与治疗。微生物在人体健康与疾病中的作用研究日益增多，普雷沃氏菌属(以下简称普氏菌属)是人类肠道核心菌属之一。现有研究关于普氏菌属影响哮喘发生发展的机制尚不完全清楚，普氏菌属可能通过免疫调节、代谢调控等机制在哮喘病理生理过程中发挥作用。本综述旨在探讨肠道普氏菌属影响哮喘发生发展过程的作用机制，可增加读者对肠道普氏菌属与哮喘关联性的认识，为寻找研究新方向提供依据。
Abstract: In recent decades, asthma has been a common chronic respiratory disease in children. The prevalence of asthma in children in China has generally been on the rise, causing great disease harm and economic burden. Research on the causes and pathogenesis of asthma is beneficial to the prevention and treatment of asthma. There is an increasing number of studies on the role of microorganisms in human health and disease. Prevotella is one of the core bacterial genera in the human intestine. Existing studies have not yet fully clarified the mechanism by which Prevotella affects the occurrence and development of asthma. Prevotella may play a role in the pathophysiological process of asthma through mechanisms such as immunomodulation and metabolic regulation. This review aims to explore the mechanism of intestinal Prevotella influencing the occurrence and development of asthma, which can increase readers’ understanding of the association between intestinal Prevotella and asthma and provide a basis for finding new research directions.
文章引用：刘荟, 舒畅. 肠道普氏菌属影响哮喘发生发展的机制研究进展[J]. 临床医学进展, 2025, 15(3): 1050-1057. https://doi.org/10.12677/acm.2025.153711

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