Tribbles假激酶家族在肝癌中的研究进展
Research Progress on the Tribbles Pseudokinase Family in Liver Cancer
DOI: 10.12677/acm.2025.153741, PDF,   
作者: 陈继磊, 修 鹏*：山东大学齐鲁医学院，山东 济南；山东省千佛山医院肝胆外科，山东 济南；韩 旭：淄博市中心医院肝胆外科，山东 淄博
关键词: Tribbles假激酶；肝癌；作用机制；研究进展；Tribbles Pseudokinase； Liver Cancer； Mechanism； Research Progress
摘要: 肝癌是全球癌症相关死亡的第三大原因，存在早期诊断困难、治疗选择受限及复发率高的问题。因此，深入研究肝癌的分子机制，发现新的治疗靶点和方法，对改善肝癌诊断和预后具有重要意义。Tribbles假激酶(TRIB1、TRIB2、TRIB3)因其在调节炎症、代谢和癌症中的独特作用已经成为研究热点。它们通过调控细胞周期在肝癌中起关键作用，并可能影响治疗抵抗性和免疫逃逸机制。文章总结近年来Tribbles假激酶家族在肝癌中作用机制的研究进展，旨在为肝癌的诊断、治疗和预后提供新的思路和策略。
Abstract: Liver cancer is the third leading cause of cancer-related deaths globally, characterized by difficulties in early diagnosis, limited treatment options, and high recurrence rates. Therefore, in-depth research on the molecular mechanisms of liver cancer to discover new therapeutic targets and methods is crucial for improving liver cancer diagnosis and prognosis. Tribbles pseudokinases (TRIB1, TRIB2, TRIB3) have become research hotspots due to their unique roles in regulating inflammation, metabolism, and cancer. They play a key role in liver cancer by regulating the cell cycle and may also influence treatment resistance and immune evasion mechanisms. This paper summarizes recent research progress on the mechanisms of the Tribbles pseudokinase family in liver cancer, aiming to provide new ideas and strategies for liver cancer diagnosis, treatment, and prognosis.
文章引用：陈继磊, 韩旭, 修鹏. Tribbles假激酶家族在肝癌中的研究进展[J]. 临床医学进展, 2025, 15(3): 1295-1301. https://doi.org/10.12677/acm.2025.153741

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