类器官在子宫内膜癌中的应用
The Application of Organoids in Endometrial Cancer
DOI: 10.12677/acm.2025.153760, PDF,   
作者: 程宝凌:暨南大学第一临床医学院,广东 广州;沈 媛*:暨南大学附属第一医院妇科,广东 广州
关键词: 类器官妇科子宫内膜癌Organoids Gynecology Endometrial Cancer
摘要: 类器官(organoids)是通过细胞分选和三维培养建立的创新体外模型,在妇科疾病建模、药物筛选及肿瘤个体化治疗中展现出重要价值。作为全球高发的妇科恶性肿瘤,子宫内膜癌(endometrial cancer)的发病率逐年上升且呈年轻化趋势。尽管类器官技术尚未进入临床转化阶段,但其为探索该疾病的精准治疗提供了全新平台。本文综述类器官在子宫内膜癌研究中的最新进展。
Abstract: Organoids are innovative in vitro models established through cell sorting and three-dimensional culture, demonstrating significant value in gynecological disease modeling, drug screening, and personalized cancer treatment. As a highly prevalent gynecological malignancy worldwide, the incidence of endometrial cancer is increasing year by year and showing a trend of younger age of onset. Although the organoid technology has not yet reached the stage of clinical translation, it provides a new platform for exploring the precise treatment of this disease. This paper reviews the latest progress of organoids in the research of endometrial cancer.
文章引用:程宝凌, 沈媛. 类器官在子宫内膜癌中的应用[J]. 临床医学进展, 2025, 15(3): 1437-1442. https://doi.org/10.12677/acm.2025.153760

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