下颌前磨牙区骨破坏性外周型巨细胞肉芽肿诊疗一例
Osteodestructive Peripheral Giant Cell Granulomas in Mandibular Premolar Area Diagnosis and Treatment: A Case Report
DOI: 10.12677/acm.2025.153772, PDF,    科研立项经费支持
作者: 钟帅祺, 雷利红*：浙江大学医学院附属第二医院牙周病专科，浙江 杭州
关键词: 外周型巨细胞肉芽肿；牙龈瘤；多核巨细胞；Peripheral Giant Cell Granuloma； Epulis； Multinuclear Giant Cell
摘要: 外周型巨细胞肉芽肿是一种来源于牙周膜或骨膜的反应性增生性病变，可引起邻近牙周组织的明显破坏，是牙龈瘤中少见且复发率较高的分型。本文报道1例发生于下颌骨前磨牙区，具有典型临床及病理特征的骨破坏性外周型巨细胞肉芽肿，分析总结其诊断特征、治疗及预后，以期为临床外周型巨细胞肉芽肿诊疗提供参考。
Abstract: Peripheral giant cell granuloma (PGCG) is a kind of reactive hyperplastic lesion derived from the periodontal ligament or periosteum, which can cause obvious destruction of adjacent periodontal tissues. It is a rare type of epulis with a high recurrence rate. This paper presents a case of osteodestructive PGCG occurring in the mandibular premolar region, exhibiting typical clinical and pathological features. The study analyzes and summarizes its diagnostic characteristics, treatment, and prognosis, aiming to provide reference for the diagnosis and treatment of PGCG in the Chinese population.
文章引用：钟帅祺, 雷利红. 下颌前磨牙区骨破坏性外周型巨细胞肉芽肿诊疗一例[J]. 临床医学进展, 2025, 15(3): 1524-1532. https://doi.org/10.12677/acm.2025.153772

参考文献

[1] Shadman, N., Ebrahimi, S.F., Jafari, S., et al. (2009) Peripheral Giant Cell Granuloma: A Review of 123 Cases. Dental Research Journal (Isfahan), 6, 47-50.
[2] Ahmed, A. and Naidu, A. (2021) Towards Better Understanding of Giant Cell Granulomas of the Oral Cavity. Journal of Clinical Pathology, 74, 483-490. [Google Scholar] [CrossRef] [PubMed]
[3] Savage, N. and Daly, C. (2010) Gingival Enlargements and Localized Gingival Overgrowths. Australian Dental Journal, 55, 55-60. [Google Scholar] [CrossRef] [PubMed]
[4] Zhao, N., Yesibulati, Y., Xiayizhati, P., He, Y., Xia, R. and Yan, X. (2023) A Large-Cohort Study of 2971 Cases of Epulis: Focusing on Risk Factors Associated with Recurrence. BMC Oral Health, 23, Article No. 229. [Google Scholar] [CrossRef] [PubMed]
[5] Doddawad, V.G., Shivananda, S., Girish, M. and Bhuyan, L. (2022) Delayed Eruption of Tooth Due to Peripheral Giant-Cell Granuloma: An Unusual Presentation and Treatment in 15-Year-Old Child Patient. Journal of Pharmacy and Bioallied Sciences, 14, S1079-S1081. [Google Scholar] [CrossRef] [PubMed]
[6] Chrcanovic, B.R., Gomes, C.C. and Gomez, R.S. (2018) Peripheral Giant Cell Granuloma: An Updated Analysis of 2824 Cases Reported in the Literature. Journal of Oral Pathology & Medicine, 47, 454-459. [Google Scholar] [CrossRef] [PubMed]
[7] Polizzi, B., Albanese, A., Giannatempo, G., et al. (2013) Laser-Assisted Surgery in Oral Medicine: Treatment of Fibrous Epulis with Diode 915 nm. Annals of Stomatology (Roma), 4, 37.
[8] 张诗柳, 朱光勋. 牙龈瘤治疗后复发的临床探讨[J]. 临床口腔医学杂志, 2018, 34(7): 445-447.
[9] Román-Quesada, N., González-Navarro, B., Izquierdo-Gómez, K., Jané-Salas, E., Marí-Roig, A., Estrugo-Devesa, A., et al. (2021) An Analysis of the Prevalence of Peripheral Giant Cell Granuloma and Pyogenic Granuloma in Relation to a Dental Implant. BMC Oral Health, 21, Article No. 204. [Google Scholar] [CrossRef] [PubMed]
[10] Baesso, R.C.P., de Lima Jacy Monteiro Barki, M.C., de Souza Azevedo, R., da Costa Fontes, K.B.F., Pereira, D.L., Tucci, R., et al. (2019) Peripheral Giant Cell Granuloma Associated with a Dental Implant. BMC Oral Health, 19, Article No. 283. [Google Scholar] [CrossRef] [PubMed]
[11] Nagar, S.R., Bansal, S., Jashnani, K. and Desai, R.S. (2022) A Comparative Clinicopathological Study of Giant Cell Tumour (GCT), Central Giant Cell Granuloma (CGCG) and Peripheral Giant Cell Granuloma (PGCG). Journal of Maxillofacial and Oral Surgery, 22, 485-501. [Google Scholar] [CrossRef] [PubMed]
[12] Sarode, S.C. and Sarode, G.S. (2013) Cellular Cannibalism in Central and Peripheral Giant Cell Granuloma of the Oral Cavity Can Predict Biological Behavior of the Lesion. Journal of Oral Pathology & Medicine, 43, 459-463. [Google Scholar] [CrossRef] [PubMed]
[13] 柯晓菁, 金讴, 闫福华, 等. 234例牙龈瘤患者的临床特征及复发防范分析[J]. 口腔医学研究, 2022, 38(5): 429-435.
[14] Akerzoul, N. and TourTouré, B. (2023) Surgical Excision of Peripheral Giant Cell Granuloma of the Maxilla: A Case Report. Pan African Medical Journal, 44, Article No. 141. [Google Scholar] [CrossRef] [PubMed]
[15] Hajishengallis, G. (2014) Immunomicrobial Pathogenesis of Periodontitis: Keystones, Pathobionts, and Host Response. Trends in Immunology, 35, 3-11. [Google Scholar] [CrossRef] [PubMed]
[16] Hajishengallis, G. and Lamont, R.J. (2021) Polymicrobial Communities in Periodontal Disease: Their Quasi‐Organismal Nature and Dialogue with the Host. Periodontology 2000, 86, 210-230. [Google Scholar] [CrossRef] [PubMed]
[17] Jiang, Y., Fang, B., Xu, B. and Chen, L. (2019) The RAS-PI3K-AKT-NF-κB Pathway Transcriptionally Regulates the Expression of BCL2 Family and IAP Family Genes and Inhibits Apoptosis in Fibrous Epulis. Journal of Clinical Laboratory Analysis, 34, e23102. [Google Scholar] [CrossRef] [PubMed]
[18] Motamedi, M.H.K., Eshghyar, N., Jafari, S.M., Lassemi, E., Navi, F., Abbas, F.M., et al. (2007) Peripheral and Central Giant Cell Granulomas of the Jaws: A Demographic Study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 103, e39-e43. [Google Scholar] [CrossRef] [PubMed]
[19] Lester, S.R., Cordell, K.G., Rosebush, M.S., Palaiologou, A.A. and Maney, P. (2014) Peripheral Giant Cell Granulomas: A Series of 279 Cases. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 118, 475-482. [Google Scholar] [CrossRef] [PubMed]
[20] Hallikeri, K. and Babu, B. (2017) Reactive Lesions of Oral Cavity: A Retrospective Study of 659 Cases. Journal of Indian Society of Periodontology, 21, 258-263. [Google Scholar] [CrossRef] [PubMed]
[21] Krishnapillai, R., Punnoose, K., Angadi, P.V. and Koneru, A. (2012) Oral Pyogenic Granuloma—A Review of 215 Cases in a South Indian Teaching Hospital, Karnataka, over a Period of 20 Years. Oral and Maxillofacial Surgery, 16, 305-309. [Google Scholar] [CrossRef] [PubMed]
[22] Boffano, P., Benech, R., Roccia, F., Gallesio, C., Garzaro, M. and Pecorari, G. (2013) Review of Peripheral Giant Cell Granulomas. Journal of Craniofacial Surgery, 24, 2206-2208. [Google Scholar] [CrossRef] [PubMed]
[23] 孟焕新. 牙周病学[M]. 第5版. 北京: 人民卫生出版社, 2020: 140-141.
[24] Chrcanovic, B.R., Gomes, C.C. and Gomez, R.S. (2019) Peripheral Giant Cell Granuloma Associated with Dental Implants: A Systematic Review. Journal of Stomatology, Oral and Maxillofacial Surgery, 120, 456-461. [Google Scholar] [CrossRef] [PubMed]
[25] Halperin‐Sternfeld, M., Sabo, E. and Akrish, S. (2016) The Pathogenesis of Implant‐Related Reactive Lesions: A Clinical, Histologic and Polarized Light Microscopy Study. Journal of Periodontology, 87, 502-510. [Google Scholar] [CrossRef] [PubMed]
[26] Abofoul, S., Hurvitz, A.Z., Grienstein, O.K., Shuster, A., Vered, M., Edel, J., et al. (2022) Peripheral Giant Cell Granuloma Associated with Dental Implants: Case‐Series. Clinical Implant Dentistry and Related Research, 24, 133-137. [Google Scholar] [CrossRef] [PubMed]

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