寰椎横韧带断裂诊疗的研究进展
Research Progress on the Diagnosis and Treatment of Transverse Atlantal Ligament Rupture
摘要: 寰椎横韧带(Transverse Atlantal Ligament, TAL)断裂常导致寰枢椎不稳(Atlantoaxial Instability, AAI),甚至引起高位脊髓压迫从而危及生命。随着影像学技术的发展和脊柱外科手术技术的进步,TAL断裂的诊断和治疗水平有了显著提高,但仍存在诊断方式的选择争议较多、手术创伤相对较大和临床获益不明确等诸多挑战。本文综述了寰椎横韧带断裂的诊断方法、治疗策略的相关研究进展,旨在为临床医生提供参考,以更好地管理此类患者。
Abstract: The transverse atlantal ligament (TAL) rupture often leads to atlantoaxial instability (AAI) and may even cause high cervical spinal cord compression, which is life-threatening. With the development of imaging technology and the advancement of spinal surgery techniques, the diagnosis and treatment of TAL rupture have significantly improved. However, there are still many challenges, such as controversies in the choice of diagnostic methods, relatively large surgical trauma, and unclear clinical benefits. This article reviews the research progress on the diagnostic methods and treatment strategies for TAL rupture, aiming to provide a reference for clinicians to better manage such patients.
文章引用:杜秋, 沈凯. 寰椎横韧带断裂诊疗的研究进展[J]. 临床医学进展, 2025, 15(3): 1540-1545. https://doi.org/10.12677/acm.2025.153774

参考文献

[1] Robertson, P.A., Tsitsopoulos, P.P., Voronov, L.I., Havey, R.M. and Patwardhan, A.G. (2012) Biomechanical Investigation of a Novel Integrated Device for Intra-Articular Stabilization of the C1-C2 (Atlantoaxial) Joint. The Spine Journal, 12, 136-142. [Google Scholar] [CrossRef] [PubMed]
[2] Findlay, J.M. (1996) Injuries Involving the Transverse Atlantal Ligament: Classification and Treatment Guidelines Based Upon Experience with 39 Injuries. Neurosurgery, 39, 210-210. [Google Scholar] [CrossRef] [PubMed]
[3] Lee, J.C., Lee, S., Peters, C. and Riew, K.D. (2014) Risk-factor Analysis of Adjacent-Segment Pathology Requiring Surgery Following Anterior, Posterior, Fusion, and Nonfusion Cervical Spine Operations: Survivorship Analysis of 1358 Patients. The Journal of Bone and Joint Surgery-American Volume, 96, 1761-1767. [Google Scholar] [CrossRef] [PubMed]
[4] 孙麟, 马迅. 寰枢韧带复合损伤[J]. 中国药物与临床, 2005(9): 684-686.
[5] Dickman, C.A., Mamourian, A., Sonntag, V.K.H. and Drayer, B.P. (1991) Magnetic Resonance Imaging of the Transverse Atlantal Ligament for the Evaluation of Atlantoaxial Instability. Journal of Neurosurgery, 75, 221-227. [Google Scholar] [CrossRef] [PubMed]
[6] 夏虹, 钟世镇, 赵卫东, 尹东, 张美超. 寰椎横韧带的形态特点及其生物力学特性研究[J]. 中国临床解剖学杂志, 2003(3): 266-268.
[7] Panjabi, M.M., Crisco, J.J., Lydon, C. and Dvorak, J. (1998) The Mechanical Properties of Human Alar and Transverse Ligaments at Slow and Fast Extension Rates. Clinical Biomechanics, 13, 112-120. [Google Scholar] [CrossRef] [PubMed]
[8] Dvorak, J., Schneider, E., Saldinger, P. and Rahn, B. (1988) Biomechanics of the Craniocervical Region: The Alar and Transverse Ligaments. Journal of Orthopaedic Research, 6, 452-461. [Google Scholar] [CrossRef] [PubMed]
[9] Ishak, B., Dupont, G., Lachkar, S., Yilmaz, E., Glinski, A.V., Altafulla, J., et al. (2020) Update on the Biomechanics of the Craniocervical Junction—Part I: Transverse Atlantal Ligament in the Elderly. Global Spine Journal, 11, 180-186. [Google Scholar] [CrossRef] [PubMed]
[10] 陈金水. 寰椎横韧带损伤机制及其断裂模型的有限元分析[D]: [博士学位论文]. 上海: 第二军医大学, 2014.
[11] Spence, K.F., Decker, S. and Sell, K.W. (1970) Bursting Atlantal Fracture Associated with Rupture of the Transverse Ligament. The Journal of Bone & Joint Surgery, 52, 543-549. [Google Scholar] [CrossRef
[12] Liu, P., Zhu, J., Wang, Z., Jin, Y., Wang, Y., Fan, W., et al. (2019) “Rule of Spence” and Dickman’s Classification of Transverse Atlantal Ligament Injury Revisited: Discrepancy of Prediction on Atlantoaxial Stability Based on Clinical Outcome of Nonoperative Treatment for Atlas Fractures. Spine, 44, E306-E314. [Google Scholar] [CrossRef] [PubMed]
[13] Heller, J.G., Viroslav, S. and Hudson, T. (1993) Jefferson Fractures: The Role of Magnification Artifact in Assessing Transverse Ligament Integrity. Journal of Spinal Disorders, 6, 392-396. [Google Scholar] [CrossRef
[14] Woods, R.O., Inceoglu, S., Akpolat, Y.T., Cheng, W.K., Jabo, B. and Danisa, O. (2017) C1 Lateral Mass Displacement and Transverse Atlantal Ligament Failure in Jefferson’s Fracture: A Biomechanical Study of the “Rule of Spence”. Neurosurgery, 82, 226-231. [Google Scholar] [CrossRef] [PubMed]
[15] Perez-Orribo, L., Kalb, S., Snyder, L.A., Hsu, F., Malhotra, D., Lefevre, R.D., et al. (2016) Comparison of CT versus MRI Measurements of Transverse Atlantal Ligament Integrity in Craniovertebral Junction Injuries. Part 2: A New Ct-Based Alternative for Assessing Transverse Ligament Integrity. Journal of Neurosurgery: Spine, 24, 903-909. [Google Scholar] [CrossRef] [PubMed]
[16] Radcliff, K.E., Sonagli, M.A., Rodrigues, L.M., Sidhu, G.S., Albert, T.J. and Vaccaro, A.R. (2013) Does C1 Fracture Displacement Correlate with Transverse Ligament Integrity? Orthopaedic Surgery, 5, 94-99. [Google Scholar] [CrossRef] [PubMed]
[17] Mueller, K., MacConnell, A., Berkowitz, F. and Voyadzis, J. (2019) Morphological Classification of the Tubercle of Insertion of the Transverse Atlantal Ligament: A Computer Tomography-Based Anatomical Study of 200 Subjects. The Neuroradiology Journal, 32, 426-430. [Google Scholar] [CrossRef] [PubMed]
[18] Shatsky, J., Bellabarba, C., Nguyen, Q. and Bransford, R.J. (2016) A Retrospective Review of Fixation of C1 Ring Fractures—Does the Transverse Atlantal Ligament (TAL) Really Matter? The Spine Journal, 16, 372-379. [Google Scholar] [CrossRef] [PubMed]
[19] Zhang, P., Jin, G., Sun, Z., Jiang, J. and Liu, Q. (2023) An in Vitro Biomechanical Study of the Ectopic Functional Reconstruction of the Transverse Ligament of Atlas. World Neurosurgery, 172, e220-e224. [Google Scholar] [CrossRef] [PubMed]
[20] Hu, Y., Yang, S.H., Xie, H., et al. (2007) Quantitative Anatomic Study of Atlanto-Odontoid Joint and Design of an Artificial Atlan-to-Odontoid Joint for the Orthopedic Clinic. Chinese Journal of Traumatology, 10, 138-144.
[21] Lu, B., He, X.J., Zhao, C.G., Li, H.P. and Wang, D. (2008) Artificial Atlanto-Odontoid Joint Replacement through a Transoral Approach. European Spine Journal, 18, 109-117. [Google Scholar] [CrossRef] [PubMed]
[22] Cai, X., He, X., Li, H. and Wang, D. (2013) Total Atlanto-Odontoid Joint Arthroplasty System: A Novel Motion Preservation Device for Atlantoaxial Instability after Odontoidectomy. Spine, 38, E451-E457. [Google Scholar] [CrossRef] [PubMed]
[23] Zang, Q., Li, J., Liu, Y., Li, H., Cao, K., Guo, S., et al. (2021) Atlantoaxial Non-Fusion Using Biomimetic Artificial Atlanto-Odontoid Joint: Technical Innovation and Initial Biomechanical Study. Spine, 47, 825-832. [Google Scholar] [CrossRef] [PubMed]
[24] Chen, J., Zhou, F., Ni, B., Guo, Q., Guan, H., Xu, T., et al. (2016) New Posterior Atlantoaxial Restricted Non-Fusion Fixation for Atlantoaxial Instability: A Biomechanical Study. Neurosurgery, 78, 735-741. [Google Scholar] [CrossRef] [PubMed]
[25] Shen, K., Deng, Z., Yang, J., Liu, C. and Zhang, R. (2018) Novel Posterior Artificial Atlanto-Odontoid Joint for Atlantoaxial Instability: A Biomechanical Study. Journal of Neurosurgery: Spine, 28, 459-466. [Google Scholar] [CrossRef] [PubMed]