精神疾病与胃肠道疾病风险之间的相关性研究：孟德尔随机化分析
Exploring the Correlation between Psychiatric Disorders and the Risk of Gastrointestinal Tract Disorders: A Mendelian Randomization Analysis
DOI: 10.12677/acm.2025.153790, PDF,   
作者: 罗 杰, 周世骥*：重庆医科大学附属第二医院胃肠外科，重庆
关键词: 胃肠道疾病；孟德尔随机化；精神疾病；Gastrointestinal Tract Disorder； Mendelian Randomization； Psychiatric Disorder
摘要: 本研究采用孟德尔随机化分析探讨精神疾病与胃肠道疾病风险之间的因果关系。利用精神基因组学联盟(PGC)的GWAS数据，选取精神分裂症、重度抑郁症、双相情感障碍和创伤后应激障碍(PTSD)相关的SNP作为工具变量，并结合IEU数据库的胃肠道疾病数据，分析其对胃食管反流病(GERD)、胃溃疡、十二指肠溃疡和慢性胃炎的影响。结果显示，重度抑郁症显著增加GERD (OR = 1.505, P = 2.57 × 10−13)和胃溃疡(OR = 1.294, P = 1.48 × 10−4)的风险，而PTSD也增加了GERD的风险(OR = 1.180, P = 0.003)，但其他精神疾病与胃肠道疾病之间未发现显著相关性。本研究揭示了重度抑郁症和PTSD对GERD的潜在致病作用，同时发现重度抑郁症可能增加胃溃疡的风险，为精神疾病患者的胃肠道健康管理提供了新的科学依据。
Abstract: This study utilized Mendelian randomization analysis to explore the causal relationship between psychiatric disorders and the risk of gastrointestinal (GIT) diseases. GWAS data from the Psychiatric Genomics Consortium (PGC) were used, selecting SNPs associated with schizophrenia, major depressive disorder, bipolar disorder, and post-traumatic stress disorder (PTSD) as instrumental variables. GIT disease data were obtained from the IEU database to analyze their effects on gastroesophageal reflux disease (GERD), gastric ulcer, duodenal ulcer, and chronic gastritis. The results showed that major depressive disorder significantly increased the risk of GERD (OR = 1.505, P = 2.57 × 10−13) and gastric ulcers (OR = 1.294, P = 1.48 × 10−4), while PTSD also increased the risk of GERD (OR = 1.180, P = 0.003). However, no significant association was found between other psychiatric disorders and GIT diseases. This study highlights the potential pathogenic role of major depressive disorder and PTSD in GERD and suggests that major depressive disorder may also increase the risk of gastric ulcers, providing new scientific evidence for the gastrointestinal health management of psychiatric patients.
文章引用：罗杰, 周世骥. 精神疾病与胃肠道疾病风险之间的相关性研究：孟德尔随机化分析[J]. 临床医学进展, 2025, 15(3): 1668-1678. https://doi.org/10.12677/acm.2025.153790

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