难治性痛风合并多种并发症治疗1例

Treatment of a Case of Refractory Gout with Multiple Complications

摘要: 目的：探讨穿虎祛痛合剂联合秋水仙碱治疗难治性痛风合并多种并发症的疗效。方法：报告1例长期应用激素治疗难治性痛风后导致多种并发症的患者应用穿虎祛痛合剂联合秋水仙碱治疗的临床资料。结果：在停用激素后，应用穿虎祛痛合剂联合小剂量秋水仙碱治疗后，患者双踝关节疼痛显著减轻，关节肿痛也没有加重的现象，痛风发作频率明显减少，尿酸下降，血糖控制良好且蛋白尿转阴，无胸闷憋气等冠心病症状，并未再发生骨质疏松骨折及下肢血栓。结论：难治性痛风患者给予穿虎祛痛合剂联合秋水仙碱治疗可减少激素治疗带来的各种并发症，为难治性痛风合并多种并发疾病提供新思路。

Abstract: Objective: To evaluate the efficacy of Chuanhu Qutong mixture in conjunction with colchicine for the treatment of refractory gout accompanied by multiple complications. Methods: This article presents the clinical data from a case study involving the use of Chuanhu Qutong mixture in conjunction with colchicine for managing multiple complications arising from prolonged glucocorticoid therapy in a patient with refractory gout. Results: Following the discontinuation of glucocorticoids, the patient received Chuanhu Qutong mixture combined with a low dose of colchicine. Significant relief was observed in bilateral ankle joint pain, with no exacerbation of joint swelling or pain. The frequency of gout attacks markedly decreased, serum uric acid levels declined, blood glucose was well controlled, proteinuria became negative, and there were no recurrent symptoms of coronary heart disease such as chest tightness or breathlessness, osteoporosis fractures, or lower extremity thrombosis. Conclusion: The combination of Chuanhu Qutong mixture and colchicine can mitigate complications associated with glucocorticoid therapy in patients with refractory gout and provide new therapeutic insights for managing this condition with multiple concurrent diseases.