长链非编码RNA在胃癌血管生成中的研究进展
Research Progress of Long Non-Coding RNAs in Gastric Cancer Angiogenesis
DOI: 10.12677/acm.2025.153861, PDF,   
作者: 刘 攀：华北理工大学临床医学院，河北 唐山；王长友*：华北理工大学附属医院胃肠肿瘤外科，河北 唐山
关键词: 长链非编码RNA；胃癌；血管生成；Long Non-Coding RNA； Gastric Cancer； Angiogenesis
摘要: 胃癌是全球最常见的恶性肿瘤之一，也是导致癌症相关死亡的主要原因之一。血管生成是肿瘤生长和转移的关键过程，异常的血管生成在胃癌的发生和发展中起着重要作用。近年来，长链非编码RNA作为一类不编码蛋白质但具有重要功能的分子，在肿瘤血管生成中发挥了关键作用。长链非编码RNA通过调控血管内皮生长因子信号通路、血管生成拟态及内皮细胞的活性等途径，促进胃癌血管生成，推动肿瘤进展。本文主要综述了长链非编码RNA在胃癌血管生成中的研究进展，并探讨了其通过不同机制影响胃癌血管生成的分子机制。
Abstract: Gastric cancer is one of the most prevalent malignant tumors globally and a leading cause of cancer-related mortality. Angiogenesis plays a pivotal role in tumor growth and metastasis, with aberrant vascular formation being a key factor in the onset and progression of gastric cancer. In recent years, long non-coding RNAs (lncRNAs), which do not encode proteins but perform critical regulatory functions, have emerged as significant contributors to tumor angiogenesis. LncRNAs modulate angiogenesis in gastric cancer by regulating the Vascular Endothelial Growth Factor (VEGF) signaling pathway, vascular mimicry, and endothelial cell activity, thereby promoting tumor vascularization and progression. This review summarizes the research advances in lncRNAs in gastric cancer angiogenesis and explores the molecular mechanisms through which they influence gastric cancer through different mechanisms.
文章引用：刘攀, 王长友. 长链非编码RNA在胃癌血管生成中的研究进展[J]. 临床医学进展, 2025, 15(3): 2240-2245. https://doi.org/10.12677/acm.2025.153861

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