真人养脏汤核心成分治疗溃疡性结肠炎的网络药理学研究

Network Pharmacology Study on the Key Components of Zhenren Yangzang Decoction in the Treatment of Ulcerative Colitis

摘要: 目的：采用网络药理学方法研究真人养脏汤治疗溃疡性结肠炎(UC)的作用机制。方法：在相关数据库中筛选真人养脏汤的有效成分和潜在靶点，构建化合物–靶点网络。然后筛选UC的靶点，所得出共同的靶点，形成PPI网络用于预测核心的靶点。并对所得到的结果进行GO和KEGG富集分析。结果：共预测了6种有效成分和77个共同靶点。山萘酚，B-谷甾醇，玫瑰树碱，鞣花酸，豆固醇，异癸酸为药物关键有效活性成分，作用机制可能与癌症信号通路、脂质与动脉粥样硬化通路、化学致癌–受体激活通路、乙肝通路、人类疱疹病毒第四型感染通路、人类免疫缺陷病毒感染通路等信号通路有关。HSP90AA1、MAPK8、TNF、CASP3是UC治疗的关键靶点。结论。本研究体现了ZRYZ多成分、多靶点、多通路治疗溃疡性结肠炎的复杂网络关系，为治疗UC提供了思路。

Abstract: Objective: To study the mechanism of action of ZRYZ for the treatment of ulcerative colitis (UC) using a network pharmacology approach. Methods: We screened the active ingredients and potential targets of ZRYZ in relevant databases, and constructed a compound-target network. Then the targets of UC were screened, and the resulting common targets were used to construct a PPI network to further identify the core targets. And the results were analyzed by GO and KEGG enrichment. Results: A total of 6 active ingredients and 77 common targets were predicted. Sennosol, B-sitosterol, rosmarinic acid, ellagic acid, stigmasterol, and isodecanoic acid were the key active ingredients of the drug, and the mechanism of action might be related to the signaling pathways of cancer signaling pathway, lipid and atherosclerosis pathway, chemo oncogenic-receptor-activated pathway, hepatitis B pathway, human herpesvirus type IV infection pathway, and human immunodeficiency virus infection pathway, etc. HSP90AA1, MAPK8, TNF, and CASP3 are key targets for UC therapy. Conclusion. This study exemplifies the complex network relationship of ZRYZ multi-component, multi-target, and multi-pathway for the treatment of ulcerative colitis, which provides ideas for the treatment of UC.