阿片类药物治疗癌痛的研究进展
Research Progress on Opioids in the Treatment of Cancer Pain
摘要: 本文聚焦阿片类药物与癌痛死亡率的关系，阐述其在癌痛治疗中的关键地位，剖析吗啡、羟考酮、芬太尼等常见阿片类药物促进肿瘤进展的多方面机制，涵盖对肿瘤细胞增殖、免疫功能、血管生成的影响等。同时介绍阿片类药物常见副作用及治疗方法，强调便秘治疗的多种手段。综合分析得出阿片类药物在癌痛管理中利弊共存，临床使用需权衡考量，制定个性化方案，加强副作用管理。未来应深入探究潜在机制，为临床决策提供更精准依据，在有效控制癌痛的同时降低肿瘤进展与死亡风险。
Abstract: This article focuses on the relationship between opioids and cancer pain mortality, elucidating their critical role in cancer pain management, and analyzing the multifaceted mechanisms by which common opioids such as morphine, oxycodone, and fentanyl promote tumor progression, including effects on tumor cell proliferation, immune function, and angiogenesis. It also introduces common side effects of opioids and their treatments, emphasizing various approaches for managing constipation. A comprehensive analysis reveals that opioids present a double-edged sword in cancer pain management, requiring clinicians to balance benefits and risks, develop personalized regimens, and enhance side effect management. Future research should delve into underlying mechanisms to provide precise scientific evidence for clinical decision-making, aiming to control cancer pain effectively while reducing tumor progression and mortality risks.
文章引用：张明昊, 屈妮妮. 阿片类药物治疗癌痛的研究进展[J]. 临床个性化医学, 2025, 4(2): 458-463. https://doi.org/10.12677/jcpm.2025.42200

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