小肠梗阻的综合诊治现状:影像学诊断、血清标志物与治疗策略
Current Diagnosis and Treatment of Small Bowel Obstruction: Imaging Diagnosis, Serum Biomarkers, and Treatment Strategies
摘要: 小肠梗阻(SBO)是临床常见的急腹症,若未能及时诊断和处理,可能引发严重并发症,甚至死亡。特别是在老年患者中,由于生理机能下降,肠坏死的发生率较高。本文回顾了小肠梗阻的诊断方法、影像学检查及治疗进展,重点讨论了CT、X线、超声和MRI等影像学手段在诊断中的应用,特别是如何通过影像学特征预测肠缺血和坏死。此外,文章还探讨了生物标志物(如乳酸、D-二聚体、PCT和I-FABP)在肠缺血诊断中的潜力。手术治疗和保守治疗的适应症及决策依据也得到了详细分析。尽管现有诊疗方案已取得一定成效,但对于早期肠绞窄和缺血的识别仍存在挑战,未来需要更多多中心研究优化诊断和治疗策略。
Abstract: Small bowel obstruction (SBO) is a common acute abdominal condition, which, if not diagnosed and managed promptly, may lead to severe complications, including death. This risk is particularly higher in elderly patients due to diminished physiological function and increased likelihood of bowel necrosis. This review discusses the diagnostic methods, imaging techniques, and therapeutic advances in SBO, with a focus on the use of CT, X-ray, ultrasound, and MRI in diagnosis, particularly in predicting bowel ischemia and necrosis through imaging features. Furthermore, the potential of serum biomarkers such as lactate, D-dimer, procalcitonin (PCT), and intestinal fatty acid-binding protein (I-FABP) in diagnosing bowel ischemia is explored. The indications for and decision-making processes surrounding both surgical and conservative treatments are also analyzed. While current diagnosis and treatment strategies have shown effectiveness, early identification of bowel strangulation and ischemia remains a challenge, highlighting the need for more multicenter studies to optimize diagnosis and treatment strategies.
文章引用:蔡丞俊, 马冰清, 张进祥. 小肠梗阻的综合诊治现状:影像学诊断、血清标志物与治疗策略[J]. 临床医学进展, 2025, 15(4): 97-106. https://doi.org/10.12677/acm.2025.154906

参考文献

[1] Ellis, H. (1997) The Clinical Significance of Adhesions: Focus on Intestinal Obstruction. The European Journal of Surgery. Supplement, No. 577, 5-9.
[2] Miettinen, P., Pasanen, P., Salonen, A., Lahtinen, J. and Alhava, E. (1996) The Outcome of Elderly Patients after Operation for Acute Abdomen. Annales Chirurgiae et Gynaecologiae, 85, 11-15.
[3] Sikirica, V., Bapat, B., Candrilli, S.D., Davis, K.L., Wilson, M. and Johns, A. (2011) The Inpatient Burden of Abdominal and Gynecological Adhesiolysis in the US. BMC Surgery, 11, Article No. 13. [Google Scholar] [CrossRef] [PubMed]
[4] Kyuno, T., Otsuka, K., Kobayashi, M., Yoshida, E., Sato, K., Kawagishi, R., et al. (2022) Time Limit to Rescue Intestine with Viability at Risk Caused by Blood Flow Disruption in Patients Presenting with Acute Abdomen. Surgery Today, 52, 1627-1633. [Google Scholar] [CrossRef] [PubMed]
[5] Nelms, D.W. and Kann, B.R. (2021) Imaging Modalities for Evaluation of Intestinal Obstruction. Clinics in Colon and Rectal Surgery, 34, 205-218. [Google Scholar] [CrossRef] [PubMed]
[6] Feister, K., Konstantinoff, K., Hamade, M. and Mellnick, V. (2024) Pearls and Pitfalls of Imaging Small Bowel Obstruction. Canadian Association of Radiologists Journal, 75, 631-643. [Google Scholar] [CrossRef] [PubMed]
[7] Abbas, S.M., Bissett, I.P. and Parry, B.R. (2007) Meta-Analysis of Oral Water-Soluble Contrast Agent in the Management of Adhesive Small Bowel Obstruction. British Journal of Surgery, 94, 404-411. [Google Scholar] [CrossRef] [PubMed]
[8] Piro, K., Ma, I.W.Y., Shokoohi, H. and Novak, K. (2025) Intestinal Ultrasound in Common Gastrointestinal Disorders: An Evidence-Based Approach. Medical Clinics of North America, 109, 177-189. [Google Scholar] [CrossRef] [PubMed]
[9] Shokoohi, H., Mayes, K.D., Peksa, G.D., Loesche, M.A., Becker, B.A., Boniface, K.S., et al. (2023) Multi-Center Analysis of Point-of-Care Ultrasound for Small Bowel Obstruction: A Systematic Review and Individual Patient-Level Meta-analysis. The American Journal of Emergency Medicine, 70, 144-150. [Google Scholar] [CrossRef] [PubMed]
[10] Becker, B.A., Lahham, S., Gonzales, M.A., Nomura, J.T., Bui, M.K., Truong, T.A., et al. (2019) A Prospective, Multicenter Evaluation of Point‐of‐Care Ultrasound for Small‐Bowel Obstruction in the Emergency Department. Academic Emergency Medicine, 26, 921-930. [Google Scholar] [CrossRef] [PubMed]
[11] Boniface, K.S., King, J.B., LeSaux, M.A., Haciski, S.C. and Shokoohi, H. (2020) Diagnostic Accuracy and Time-Saving Effects of Point-of-Care Ultrasonography in Patients with Small Bowel Obstruction: A Prospective Study. Annals of Emergency Medicine, 75, 246-256. [Google Scholar] [CrossRef] [PubMed]
[12] Nakamura, Y., Kondo, S., Narita, K., Maeda, S., Fonseca, D., Honda, Y., et al. (2022) Understanding CT Imaging Findings Based on the Underlying Pathophysiology in Patients with Small Bowel Ischemia. Japanese Journal of Radiology, 41, 353-366. [Google Scholar] [CrossRef] [PubMed]
[13] Maung, A.A., Johnson, D.C., Piper, G.L., Barbosa, R.R., Rowell, S.E., Bokhari, F., et al. (2012) Evaluation and Management of Small-Bowel Obstruction: An Eastern Association for the Surgery of Trauma Practice Management Guideline. Journal of Trauma and Acute Care Surgery, 73, S362-S369. [Google Scholar] [CrossRef] [PubMed]
[14] Jaidee, W., Teerasamit, W., Apisarnthanarak, P., Kongkaewpaisan, N., Panya, S. and Kaewlai, R. (2023) Small Bowel Transmural Necrosis Secondary to Acute Mesenteric Ischemia and Strangulated Obstruction: CT Findings of 49 Patients. Heliyon, 9, e17543. [Google Scholar] [CrossRef] [PubMed]
[15] Chuong, A.M., Corno, L., Beaussier, H., Boulay-Coletta, I., Millet, I., Hodel, J., et al. (2016) Assessment of Bowel Wall Enhancement for the Diagnosis of Intestinal Ischemia in Patients with Small Bowel Obstruction: Value of Adding Unenhanced CT to Contrast-Enhanced CT. Radiology, 280, 98-107. [Google Scholar] [CrossRef] [PubMed]
[16] 田晶, 成人急性小肠梗阻危险度评分系统的构建[D]: [博士学位论文]. 南京: 南京医科大学, 2018.
[17] Rondenet, C., Millet, I., Corno, L., Boulay-Coletta, I., Taourel, P. and Zins, M. (2018) Increased Unenhanced Bowel-Wall Attenuation: A Specific Sign of Bowel Necrosis in Closed-Loop Small-Bowel Obstruction. European Radiology, 28, 4225-4233. [Google Scholar] [CrossRef] [PubMed]
[18] Li, B., Qi, W., Yuan, M., Wang, H., Chen, M., Song, Z., et al. (2024) Increased Attenuation of Intestinal Contents at CT Indicates Bowel Necrosis in Closed-Loop Small Bowel Obstruction. Radiology, 310, e231710. [Google Scholar] [CrossRef] [PubMed]
[19] Taourel, P. and Zins, M. (2024) Unenhanced CT for Predicting Bowel Necrosis in Small Bowel Obstruction: Time to Adapt Our Protocol. Radiology, 310, e240001. [Google Scholar] [CrossRef] [PubMed]
[20] Olson, M.C., Navin, P.J., Welle, C.L. and Goenka, A.H. (2021) Small Bowel Radiology. Current Opinion in Gastroenterology, 37, 267-274. [Google Scholar] [CrossRef] [PubMed]
[21] Rimola, J., Torres, J., Kumar, S., Taylor, S.A. and Kucharzik, T. (2022) Recent Advances in Clinical Practice: Advances in Cross-Sectional Imaging in Inflammatory Bowel Disease. Gut, 71, 2587-2597. [Google Scholar] [CrossRef] [PubMed]
[22] Bonouvrie, D.S., van Beek, H.C., Taverne, S.B.M., Janssen, L., van der Linden, T.N., van Dielen, F.M.H., et al. (2021) Pregnant Women after Bariatric Surgery: Diagnostic Accuracy of Magnetic Resonance Imaging for Small Bowel Obstruction. Obesity Surgery, 32, 245-255. [Google Scholar] [CrossRef] [PubMed]
[23] Didier-Mathon, H., Grévent, D., Khen-Dunlop, N., Sonigo, P., Rousseau, V., Ville, Y., et al. (2021) Ultrasound and Fetal MRI Complementary Contributions to Appropriate Counseling in Small Bowel Obstruction. Fetal Diagnosis and Therapy, 48, 567-574. [Google Scholar] [CrossRef] [PubMed]
[24] Adeva-Andany, M., López-Ojén, M., Funcasta-Calderón, R., Ameneiros-Rodríguez, E., Donapetry-García, C., Vila-Altesor, M., et al. (2014) Comprehensive Review on Lactate Metabolism in Human Health. Mitochondrion, 17, 76-100. [Google Scholar] [CrossRef] [PubMed]
[25] Catena, F., De Simone, B., Coccolini, F., Di Saverio, S., Sartelli, M. and Ansaloni, L. (2019) Bowel Obstruction: A Narrative Review for All Physicians. World Journal of Emergency Surgery, 14, Article No. 20. [Google Scholar] [CrossRef] [PubMed]
[26] Lange, H. and Jäckel, R. (1994) Usefulness of Plasma Lactate Concentration in the Diagnosis of Acute Abdominal Disease. The European Journal of Surgery, 160, 381-384.
[27] Işık, N.İ., Katipoğlu, B., Turan, Ö.F., Gezer, A.E., Yazla, M. and Surel, A.A. (2024) The Significance of Initial Lactate Levels in Emergency Department Presentations of Abdominal Wall Hernia. Hernia, 28, 567-574. [Google Scholar] [CrossRef] [PubMed]
[28] Demir, I.E., Ceyhan, G.O. and Friess, H. (2012) Beyond Lactate: Is There a Role for Serum Lactate Measurement in Diagnosing Acute Mesenteric Ischemia? Digestive Surgery, 29, 226-235. [Google Scholar] [CrossRef] [PubMed]
[29] Franchini, M., Focosi, D., Pezzo, M.P. and Mannucci, P.M. (2024) Response to the Comment: “Advocating Prudent D-Dimer Testing: Constructive Perspectives and Comments on “How We Manage a High D-Dimer”. Haematologica, 109, Article 3454. [Google Scholar] [CrossRef] [PubMed]
[30] Cudnik, M.T., Darbha, S., Jones, J., Macedo, J., Stockton, S.W. and Hiestand, B.C. (2013) The Diagnosis of Acute Mesenteric Ischemia: A Systematic Review and Meta-Analysis. Academic Emergency Medicine, 20, 1087-1100. [Google Scholar] [CrossRef] [PubMed]
[31] Zhou, Y., Zhao, H., Liu, B., Qian, J., Chen, N., Wang, Y., et al. (2024) The Value of D-Dimer and Platelet-Lymphocyte Ratio Combined with CT Signs for Predicting Intestinal Ischemia in Patients with Bowel Obstruction. PLOS ONE, 19, e0305163. [Google Scholar] [CrossRef] [PubMed]
[32] Formenti, P., Gotti, M., Palmieri, F., Pastori, S., Roccaforte, V., Menozzi, A., et al. (2024) Presepsin in Critical Illness: Current Knowledge and Future Perspectives. Diagnostics, 14, Article 1311. [Google Scholar] [CrossRef] [PubMed]
[33] Cosse, C., Sabbagh, C., Kamel, S., Galmiche, A. and Regimbeau, J. (2014) Procalcitonin and Intestinal Ischemia: A Review of the Literature. World Journal of Gastroenterology, 20, 17773-17778. [Google Scholar] [CrossRef] [PubMed]
[34] Li, X., Tian, M. Liu, Y. Zhang, Y. and Chen, J. (2024) Predictive Factors of Intestinal Ischaemia in Adhesive Small Bowel Obstruction. Journal of the College of Physicians and Surgeons, 34, 146-150.
[35] Olivero, C., Carbone, F., Liberale, L. and Montecucco, F. (2024) Precision Medicine in Intestinal Ischemia: The Emerging Role of Biomarkers. Internal and Emergency Medicine. [Google Scholar] [CrossRef] [PubMed]
[36] Ding, C., Wu, Y. and Liu, X. (2020) Diagnostic Accuracy of Intestinal Fatty Acid Binding Protein for Acute Intestinal Ischemia: A Systematic Review and Meta-Analysis. Clinical Laboratory, 66. [Google Scholar] [CrossRef] [PubMed]
[37] Tamme, K., Acosta, S., Biloslavo, A., Björck, M., Casian, D., Damaskos, D., et al. (2024) Biomarkers in Prediction of Acute Mesenteric Ischaemia: A Prospective Multicentre Study (BIPAMI Study): A Study Protocol. BMC Surgery, 24, Article No. 201. [Google Scholar] [CrossRef] [PubMed]
[38] Szymanska, E., Bierla, J., Dadalski, M., Wierzbicka, A., Konopka, E., Cukrowska, B., et al. (2024) New Noninvasive Biomarkers of Intestinal Inflammation and Increased Intestinal Permeability in Pediatric Inflammatory Bowel Diseases and Their Correlation with Fecal Calprotectin: A Pilot Study. Minerva Gastroenterology, 69, 504-510. [Google Scholar] [CrossRef] [PubMed]
[39] Reintam Blaser, A., Starkopf, J., Björck, M., Forbes, A., Kase, K., Kiisk, E., et al. (2023) Diagnostic Accuracy of Biomarkers to Detect Acute Mesenteric Ischaemia in Adult Patients: A Systematic Review and Meta-Analysis. World Journal of Emergency Surgery, 18, Article No. 44. [Google Scholar] [CrossRef] [PubMed]
[40] Zoroddu, S., Zinellu, A., Carru, C. and Sotgia, S. (2024) Analytical Insights into Methods for Measuring Ischemia-Modified Albumin. Molecules, 29, Article 4636. [Google Scholar] [CrossRef] [PubMed]
[41] Cekic, A.B., Gonenc Cekic, O., Aygun, A., Pasli, S., Yaman Ozer, S., Caner Karahan, S., et al. (2020) The Diagnostic Value of Ischemia-Modified Albumin (IMA) and Signal Peptide-Cub-EGF Domain-Containing Protein-1 (SCUBE-1) in an Experimental Model of Strangulated Mechanical Bowel Obstruction. Journal of Investigative Surgery, 35, 450-456. [Google Scholar] [CrossRef] [PubMed]
[42] Dou, C., Li, K. and Wang, L. (2022) Computed Tomography Image Segmentation of the Proximal Colon by U-Net for the Clinical Study of Somatostatin Combined with Intestinal Obstruction Catheter. Computational and Mathematical Methods in Medicine, 2022, Article ID: 6868483. [Google Scholar] [CrossRef] [PubMed]
[43] Tan, Y., Chen, H., Mao, W., Yuan, Q. and Niu, J. (2020) Short-Term Clinical Outcomes after Using Novel Deeper Intubation Technique (DIT) of Ileus Tube for Acute Bowel Obstruction Patients. Gastroenterology Research and Practice, 2020, Article ID: 1625154. [Google Scholar] [CrossRef] [PubMed]
[44] Lauretta, M.P., Marino, L. and Bilotta, F. (2024) Safety and Efficacy of Opioid-Sparing Anesthesia Compared with Traditional Opioid Anesthesia: A Scoping Review. The Clinical Journal of Pain, 41, e1261. [Google Scholar] [CrossRef] [PubMed]
[45] Albalawi, H.I.H., Alyoubi, R.K.A., Alsuhaymi, N.M.M., Aldossary, F.A.K., Mohammed G, A.A., Albishi, F.M., et al. (2024) Beyond the Operating Room: A Narrative Review of Enhanced Recovery Strategies in Colorectal Surgery. Cureus, 16, e76123. [Google Scholar] [CrossRef] [PubMed]
[46] Reichert, M., Willis, F., Post, S., Schneider, M., Vilz, T., Willis, M., et al. (2024) Pharmacologic Prevention and Therapy of Postoperative Paralytic Ileus after Gastrointestinal Cancer Surgery: Systematic Review and Meta-Analysis. International Journal of Surgery, 110, 4329-4341. [Google Scholar] [CrossRef] [PubMed]
[47] Wu, Z., Wang, S., Yuan, S. and Lin, M. (2020) Clinical Efficacy and Safety of Somatostatin in the Treatment of Early Postoperative Inflammatory Small Bowel Obstruction: A Protocol for Systematic Review and Meta Analysis. Medicine, 99, e20288. [Google Scholar] [CrossRef] [PubMed]
[48] 张华秦, 薛飞. 奥曲肽结合生长抑素治疗粘连性肠梗阻患者的临床效果[J]. 临床医学研究与实践, 2023, 8(24): 54-57.
[49] Detz, D.J., Podrat, J.L., Muniz Castro, J.C., Lee, Y.K., Zheng, F., Purnell, S., et al. (2021) Small Bowel Obstruction. Current Problems in Surgery, 58, Article 100893. [Google Scholar] [CrossRef] [PubMed]
[50] Ten Broek, R.P.G., Krielen, P., Di Saverio, S., Coccolini, F., Biffl, W.L., Ansaloni, L., et al. (2018) Bologna Guidelines for Diagnosis and Management of Adhesive Small Bowel Obstruction (ASBO): 2017 Update of the Evidence-Based Guidelines from the World Society of Emergency Surgery ASBO Working Group. World Journal of Emergency Surgery, 13, Article No. 24. [Google Scholar] [CrossRef] [PubMed]
[51] Liu, X., Zhu, M., Wu, M., Cheng, Z., Wu, X. and Zhu, R. (2023) Unenhanced CT-Based Predictive Model to Identify Small Bowel Necrosis in Patients with Mechanical Small Bowel Obstruction. BMC Medical Imaging, 23, Article No. 80. [Google Scholar] [CrossRef] [PubMed]
[52] Xu, W., Zhong, Q., Cai, Y., Zhan, C., Chen, S., Wang, H., et al. (2022) Prediction and Management of Strangulated Bowel Obstruction: A Multi-Dimensional Model Analysis. BMC Gastroenterology, 22, Article No. 304. [Google Scholar] [CrossRef] [PubMed]
[53] Eze, V.N., Parry, T., Boone, D., Mallett, S. and Halligan, S. (2023) Prognostic Factors to Identify Resolution of Small Bowel Obstruction without Need for Operative Management: Systematic Review. European Radiology, 34, 3861-3871. [Google Scholar] [CrossRef] [PubMed]
[54] Suzuki, Y., Tei, M., Wakasugi, M., Masuzawa, T., Ohtsuka, M., Mikamori, M., et al. (2020) Role of Single-Incision Laparoscopic Surgery in the Management of Small Bowel Obstruction. Surgical Endoscopy, 35, 2558-2565. [Google Scholar] [CrossRef] [PubMed]
[55] Krielen, P., Di Saverio, S., ten Broek, R., Renzi, C., Zago, M., Popivanov, G., et al. (2020) Laparoscopic versus Open Approach for Adhesive Small Bowel Obstruction, a Systematic Review and Meta-Analysis of Short Term Outcomes. Journal of Trauma and Acute Care Surgery, 88, 866-874. [Google Scholar] [CrossRef] [PubMed]
[56] Quach, G. and Zielinski, M.D. (2023) Surgical Management of Small Bowel Obstruction: What You Need to Know. Journal of Trauma and Acute Care Surgery, 96, 357-363. [Google Scholar] [CrossRef] [PubMed]