急性期精神分裂症患者攻击行为与血浆IL-10相关性研究

Investigation of the Correlation between Aggressive Behavior and Plasma IL-10 in Patients with Acute Schizophrenia

摘要: 目的：本研究旨在探索急性期精神分裂症患者攻击性行为与血浆中白细胞介素-10 (IL-10)水平的相关性。方法：本研究选取69例急性期精神分裂症住院患者作为研究对象，根据外显攻击行为量表(MOAS)评分分为攻击行为组(37例)和非攻击行为组(32例)，同期选择与其年龄、性别相匹配的健康对照组(30例)采用酶联免疫吸附试验(ELISA)检测三组患者血浆IL-10水平。采用外显攻击行为量表(MOAS)评估精神分裂症患者的攻击行为，采用临床总体印象量表–严重程度量表(CGI-SI)、阳性和阴性症状量表(PANSS)、阳性和阴性症状量表–兴奋因子(PANSS-EC)等评估患者的临床症状及病情严重程度。通过统计分析控制混杂因素对结果的影响。结果：在控制药物治疗、吸烟、合并症等混杂因素中，精神分裂症患者血浆IL-10水平(Z = −4.903, P < 0.001)明显低于健康对照组。攻击行为组患者血浆IL-10水平低于无攻击行为组(P < 0.001)。血浆IL-10平与PANSS总分(r = −0.439, P < 0.001)、阳性症状分(r = −0.327, P = 0.006)、PANSS-EC分(r = −0.377, P = 0.002)呈显著负相关。结论：血浆IL-10水平与急性期精神分裂症患者攻击行为及病情严重程度具有显著相关性，炎性反应异常可能参与暴力攻击行为的发生机制。

Abstract: Objective: This study aims to explore the correlation between aggressive behavior and plasma interleukin-10 (IL-10) levels in patients with acute schizophrenia. Methods: A total of 69 inpatients with acute schizophrenia were selected as the study subjects. Based on the Modified Overt Aggression Scale (MOAS) scores, the patients were divided into an aggressive behavior group (37 patients) and a non-aggressive behavior group (32 patients). A healthy control group (30 subjects) matched for age and gender was also included. Plasma IL-10 levels were measured using the enzyme-linked immunosorbent assay (ELISA) in all three groups. The MOAS was used to assess aggressive behavior in schizophrenia patients, while the Clinical Global Impressions-Severity Scale (CGI-SI), Positive and Negative Syndrome Scale (PANSS), and PANSS Excitement Component (PANSS-EC) were used to evaluate clinical symptoms and disease severity. Results: Plasma IL-10 levels in schizophrenia patients were significantly lower than those in the healthy control group (Z = −4.903, P < 0.001). The plasma IL-10 levels in the aggressive behavior group were lower than those in the non-aggressive behavior group (P < 0.001). Plasma IL-10 levels were significantly negatively correlated with the total PANSS score (r = −0.439, P < 0.001), positive symptom score (r = −0.327, P = 0.006), and PANSS-EC score (r = −0.377, P = 0.002). Conclusion: Plasma IL-10 levels are significantly correlated with aggressive behavior and disease severity in patients with acute schizophrenia, suggesting that abnormal inflammatory responses may be involved in the pathogenesis of violent aggressive behavior.