DDIT3在恶性肿瘤中的研究进展
Research Progress of DDIT3 in Malignant Tumors
DOI: 10.12677/acm.2025.154921, PDF,    科研立项经费支持
作者: 谢文婕, 徐隽孜, 万岱宁, 司佳静, 戴文清, 郭肖肖*：南京医科大学康达学院基础医学系，江苏 连云港
关键词: DDIT3；恶性肿瘤；研究进展；DDIT3； Malignant Tumors； Research Progress
摘要: DDIT3 (DNA Damage-inducible transcript 3)，也称为CHOP (C/EBP Homologous Protein)是一种属于CCAAT/增强子结合蛋白家族的转录因子。DDIT3是肿瘤细胞中响应内质网应激和DNA损伤的关键分子。近年来，DDIT3在恶性肿瘤中的研究取得了显著进展，其在多种肿瘤的发生发展中扮演着重要角色。本综述旨在总结DDIT3在恶性肿瘤中的研究进展，探讨DDIT3的异常表达与多肿瘤恶性进展的相关性，以及作为潜在治疗靶点的可能性，为针对肿瘤的深入研究和治疗提供理论依据。
Abstract: DNA Damage-inducible transcript 3 (DDIT3), also known as C/EBP Homologous Protein (CHOP), is a transcription factor belonging to the CCAAT/enhancer-binding protein family. It plays a pivotal role in the cellular stress response pathways, responding to endoplasmic reticulum stress and DNA damage in tumor cells. Recent years have seen significant progress in the study of DDIT3 in malignant tumors, where it plays an important role in the occurrence and development of various cancers. This review aims to summarize the research progress of DDIT3 in malignant tumors, explore the correlation between the abnormal expression of DDIT3 and the malignant progression of multiple tumors, and discuss its potential as a therapeutic target, providing a theoretical basis for in-depth research and treatment of cancer.
文章引用：谢文婕, 徐隽孜, 万岱宁, 司佳静, 戴文清, 郭肖肖. DDIT3在恶性肿瘤中的研究进展[J]. 临床医学进展, 2025, 15(4): 211-215. https://doi.org/10.12677/acm.2025.154921

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