儿童急性坏死性脑病免疫学治疗进展
Research Progress in the Immunological Treatment of Acute Necrotizing Encephalopathy of Childhood
DOI: 10.12677/acm.2025.154922, PDF,   
作者: 刘旭旭*, 洪思琦#：重庆医科大学附属儿童医院神经内科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿童神经发育与认知障碍重庆市重点实验室，重庆
关键词: 急性坏死性脑病；儿童；细胞因子风暴；免疫治疗；Acute Necrotizing Encephalopathy； Children； Cytokine Storm； Immunotherapy Treatment
摘要: 儿童急性坏死性脑病(ANEC)是一种十分少见的暴发性急性脑病。通常以病毒感染相关的高热症状起病，随后迅速恶化，出现嗜睡、昏迷等进行性意识障碍表现，并伴有抽搐及局灶性神经功能缺损表现。该病起病急、病情重、发展迅速，本病预后极差，死亡率高，目前尚无针对ANEC的特异性治疗方法，通常以免疫治疗和对症支持治疗为主。早期诊断和干预对挽救患儿生命，减少病后后遗症状，提高患儿病后生活质量具有重要价值。本文回顾了近年来ANEC的相关研究进展，并重点对ANEC免疫学治疗主要研究进展进行综述，以期对ANEC的诊疗提供新的思路与方法。
Abstract: Acute necrotizing encephalopathy of childhood (ANEC) is a rare form of fulminant acute encephalopathy. It usually starts with high fever symptoms related to viral infection, and then rapidly worsens, showing progressive consciousness disorders such as drowsiness and coma, accompanied by seizures and focal neurological deficits. The disease has acute onset, severe disease and rapid development, extremely poor prognosis and high mortality. At present, there is no specific treatment for ANEC, usually immunotherapy and symptomatic supportive therapy. Early diagnosis and intervention are of great value in saving the lives of the sick children, reducing the sequelae after the disease and improving the quality of life. This paper reviews the relevant research progress of ANEC in recent years, and focuses on the progress of ANEC immunology, in order to provide new ideas and methods for the diagnosis and treatment of ANEC.
文章引用：刘旭旭, 洪思琦. 儿童急性坏死性脑病免疫学治疗进展[J]. 临床医学进展, 2025, 15(4): 216-224. https://doi.org/10.12677/acm.2025.154922

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