血浆致动脉硬化指数在早发冠心病中的研究进展
Research Progress of Atherogenic Index of Plasma in Premature Coronary Heart Disease
DOI: 10.12677/acm.2025.154943, PDF,   
作者: 魏迎丽, 王 婷, 王 荣:承德医学院临床学院,河北 承德;侯天华*:承德市中心医院心血管内科,河北 承德
关键词: 血浆致动脉硬化指数脂质代谢紊乱早发冠心病Atherogenic Index of Plasma Lipid Metabolism Disorder Premature Coronary Heart Disease
摘要: 早发冠心病的患病率随着生活方式改变逐渐升高,但其长期预后不佳。脂质代谢紊乱是动脉粥样硬化最重要的危险因素,脂质指标在预测心血管不良事件方面的研究较多,目前大多数研究仍专注于单一的脂类指标。血浆动脉致动脉硬化指数能更好地预测心血管事件的风险,可作为心血管疾病预后不良的标志物。然而,关于早发冠心病中血浆致动脉硬化指数的研究较少,本文综述了血浆致动脉硬化指数在早发冠心病中的应用及其研究进展。
Abstract: The incidence of premature coronary heart disease gradually increases with the improvement of living standards, but its long-term prognosis is poor. Lipid metabolism disorder is the most important risk factor for atherosclerosis. There are many studies on the role of lipid indicators in predicting adverse cardiovascular events, but most studies are focused on single lipid indicator. Plasma arteriosclerosis index can better predict the risk of cardiovascular events and can be used as a marker of poor prognosis of cardiovascular disease. However, there are few studies on the plasma arteriosclerosis index in premature coronary heart disease. This article reviews the application and research progress of plasma arteriosclerosis index in premature coronary heart disease.
文章引用:魏迎丽, 侯天华, 王婷, 王荣. 血浆致动脉硬化指数在早发冠心病中的研究进展[J]. 临床医学进展, 2025, 15(4): 369-377. https://doi.org/10.12677/acm.2025.154943

参考文献

[1] 国家卫生计生委合理用药专家委员会, 中国药师协会. 冠心病合理用药指南(第2版) [J]. 中国医学前沿杂志(电子版), 2018, 10(6): 1-130.
[2] 中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2022概要[J]. 中国循环杂志, 2023, 38(6): 583-612.
[3] Michos, E.D. and Choi, A.D. (2019) Coronary Artery Disease in Young Adults. Journal of the American College of Cardiology, 74, 1879-1882. [Google Scholar] [CrossRef] [PubMed]
[4] 张向群. 早发冠心病非 ST 段抬高心肌梗死的临床特点研究[J]. 中国临床实用医学, 2010, 4(5): 143-145.
[5] Zeitouni, M., Clare, R.M., Chiswell, K., Abdulrahim, J., Shah, N., Pagidipati, N.P., et al. (2020) Risk Factor Burden and Long‐Term Prognosis of Patients with Premature Coronary Artery Disease. Journal of the American Heart Association, 9, e017712. [Google Scholar] [CrossRef] [PubMed]
[6] Collet, J., Zeitouni, M., Procopi, N., Hulot, J., Silvain, J., Kerneis, M., et al. (2019) Long-Term Evolution of Premature Coronary Artery Disease. Journal of the American College of Cardiology, 74, 1868-1878. [Google Scholar] [CrossRef] [PubMed]
[7] Bouchard, K., Dans, M., Higdon, G., Quinlan, B. and Tulloch, H. (2022) Caregiver Distress and Coronary Artery Disease: Prevalence, Risk, Outcomes, and Management. Current Cardiology Reports, 24, 2081-2096. [Google Scholar] [CrossRef] [PubMed]
[8] Wang, H., Liu, Z., Shao, J., Jiang, M., Lu, X., Lin, L., et al. (2022) Pathogenesis of Premature Coronary Artery Disease: Focus on Risk Factors and Genetic Variants. Genes & Diseases, 9, 370-380. [Google Scholar] [CrossRef] [PubMed]
[9] Stone, N.J., Smith, S.C., Orringer, C.E., Rigotti, N.A., Navar, A.M., Khan, S.S., et al. (2022) Managing Atherosclerotic Cardiovascular Risk in Young Adults. Journal of the American College of Cardiology, 79, 819-836. [Google Scholar] [CrossRef] [PubMed]
[10] Lei, J., Vodovotz, Y., Tzeng, E. and Billiar, T.R. (2013) Nitric Oxide, a Protective Molecule in the Cardiovascular System. Nitric Oxide, 35, 175-185. [Google Scholar] [CrossRef] [PubMed]
[11] 欧巧云, 陶丽华, 温详, 等. 非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值与早发男性急性ST段抬高型心肌梗死发生的相关性分析[J]. 临床内科杂志, 2022, 39(5): 318-322.
[12] Förstermann, U., Xia, N. and Li, H. (2017) Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis. Circulation Research, 120, 713-735. [Google Scholar] [CrossRef] [PubMed]
[13] Khan, D.A., Ansari, W.M. and Khan, F.A. (2011) Pro/Anti-Inflammatory Cytokines in the Pathogenesis of Premature Coronary Artery Disease. Journal of Interferon & Cytokine Research, 31, 561-567. [Google Scholar] [CrossRef] [PubMed]
[14] 张晏铭, 于高修, 王聪, 等. 早发冠心病发病机制与预防的研究进展[J]. 中国临床医学, 2024, 31(3): 491-498.
[15] Tewari, S., Kumar, S., Kapoor, A., et al. (2005) Premature Coronary Artery Disease in North India: An Angiography Study of 1971 Patients. Indian Heart Journal, 57, 311-318.
[16] 刘志远, 李纲, 李玉东, 等. 早发冠心病患者冠状动脉病变特点及危险因素的临床研究[J]. 中国心血管病研究杂志, 2008, 6(9): 657-659.
[17] Gonzalez, L. and Trigatti, B.L. (2017) Macrophage Apoptosis and Necrotic Core Development in Atherosclerosis: A Rapidly Advancing Field with Clinical Relevance to Imaging and Therapy. Canadian Journal of Cardiology, 33, 303-312. [Google Scholar] [CrossRef] [PubMed]
[18] Janoudi, A., Shamoun, F.E., Kalavakunta, J.K. and Abela, G.S. (2015) Cholesterol Crystal Induced Arterial Inflammation and Destabilization of Atherosclerotic Plaque. European Heart Journal, 37, 1959-1967. [Google Scholar] [CrossRef] [PubMed]
[19] 车奕宏, 马国锋. 早发冠心病急性心肌梗死发生的危险因素及冠脉病变特点[J]. 血栓与止血学, 2021, 27(5): 780-782.
[20] Ricci, B., Cenko, E., Vasiljevic, Z., Stankovic, G., Kedev, S., Kalpak, O., et al. (2017) Acute Coronary Syndrome: The Risk to Young Women. Journal of the American Heart Association, 6. [Google Scholar] [CrossRef] [PubMed]
[21] Schoenenberger, A.W., Radovanovic, D., Stauffer, J., Windecker, S., Urban, P., Niedermaier, G., et al. (2011) Acute Coronary Syndromes in Young Patients: Presentation, Treatment and Outcome. International Journal of Cardiology, 148, 300-304. [Google Scholar] [CrossRef] [PubMed]
[22] Barbero, U., Scacciatella, P., Iannaccone, M., D’Ascenzo, F., Niccoli, G., Colombo, F., et al. (2017) Culprit Plaque Characteristics in Younger versus Older Patients with Acute Coronary Syndromes: An Optical Coherence Tomography Study from the FORMIDABLE Registry. Catheterization and Cardiovascular Interventions, 92, E1-E8. [Google Scholar] [CrossRef] [PubMed]
[23] Christiansen, M.K. (2017) Early-Onset Coronary Artery Disease Clinical and Hereditary Aspects. Danish Medical Journal, 64, B5406.
[24] Gaziano, T.A., Bitton, A., Anand, S., Abrahams-Gessel, S. and Murphy, A. (2010) Growing Epidemic of Coronary Heart Disease in Low-and Middle-Income Countries. Current Problems in Cardiology, 35, 72-115. [Google Scholar] [CrossRef] [PubMed]
[25] Gupta, P., Gan, A.T.L., Man, R.E.K., Fenwick, E.K., Tham, Y., Sabanayagam, C., et al. (2018) Risk of Incident Cardiovascular Disease and Cardiovascular Risk Factors in First and Second-Generation Indians: The Singapore Indian Eye Study. Scientific Reports, 8, Article No. 14805. [Google Scholar] [CrossRef] [PubMed]
[26] 边娟, 孙红梅, 李飞. 早发冠心病的相关血清学标志物研究进展[J]. 山东医药, 2019, 59(21): 112-114.
[27] 晋晓丽, 于力, 王岚. 早发冠心病PCI术后发生不良心血管事件的危险因素分析[J]. 中国循证心血管医学杂志, 2023, 15(6): 737-739.
[28] Khoja, A., Andraweera, P.H., Lassi, Z.S., Padhani, Z.A., Ali, A., Zheng, M., et al. (2024) Modifiable and Non-Modifiable Risk Factors for Premature Coronary Heart Disease (PCHD): Systematic Review and Meta-Analysis. Heart, Lung and Circulation, 33, 265-280. [Google Scholar] [CrossRef] [PubMed]
[29] Dobiás̆ová, M. and Frohlich, J. (2001) The Plasma Parameter Log (TG/HDL-C) as an Atherogenic Index: Correlation with Lipoprotein Particle Size and Esterification Rate Inapob-Lipoprotein-Depleted Plasma (FERHDL). Clinical Bio-chemistry, 34, 583-588. [Google Scholar] [CrossRef] [PubMed]
[30] Won, K., Heo, R., Park, H., et al. (2021) Atherogenic Index of Plasma and the Risk of Rapid Progression of Coronary Atherosclerosis beyond Traditional Risk Factors. Atherosclerosis, 324, 46-51.
[31] Zheng, H., Wu, K., Wu, W., Chen, G., Chen, Z., Cai, Z., et al. (2023) Relationship between the Cumulative Exposure to Atherogenic Index of Plasma and Ischemic Stroke: A Retrospective Cohort Study. Cardiovascular Diabetology, 22, Article No. 313. [Google Scholar] [CrossRef] [PubMed]
[32] Albosta, M.S., Grant, J.K., Taub, P., Blumenthal, R.S., Martin, S.S. and Michos, E.D. (2023) Inclisiran: A New Strategy for LDL-C Lowering and Prevention of Atherosclerotic Cardiovascular Disease. Vascular Health and Risk Management, 19, 421-431. [Google Scholar] [CrossRef] [PubMed]
[33] Hong, L., Li, X., Luo, S., Guo, Y., Zhu, C., Qing, P., et al. (2014) Association of Fibrinogen with Severity of Stable Coronary Artery Disease in Patients with Type 2 Diabetic Mellitus. Disease Markers, 2014, Article ID: 485687. [Google Scholar] [CrossRef] [PubMed]
[34] Wu, N., Ma, F., Guo, Y., Li, X., Liu, J., Qing, P., et al. (2014) Association of N-Terminal Pro-Brain Natriuretic Peptide with the Severity of Coronary Artery Disease in Patients with Normal Left Ventricular Ejection Fraction. Chinese Medical Journal, 127, 627-632. [Google Scholar] [CrossRef
[35] Sabatine, M.S., Morrow, D.A., de Lemos, J.A., Omland, T., Sloan, S., Jarolim, P., et al. (2012) Evaluation of Multiple Biomarkers of Cardiovascular Stress for Risk Prediction and Guiding Medical Therapy in Patients with Stable Coronary Disease. Circulation, 125, 233-240. [Google Scholar] [CrossRef] [PubMed]
[36] Demirtola, A.İ., Erdöl, M.A., Mammadli, A., Göktuğ Ertem, A., Yayla, Ç. and Akçay, A.B. (2024) Predicting Coronary Artery Severity in Patients Undergoing Coronary Computed Tomographic Angiography: Insights from Pan-Immune Inflammation Value and Atherogenic Index of Plasma. Nutrition, Metabolism and Cardiovascular Diseases, 34, 2289-2297. [Google Scholar] [CrossRef] [PubMed]
[37] Wu, X., Qiu, W., Yang, H., Chen, Y., Liu, J. and Zhao, G. (2024) Associations of the Triglyceride-Glucose Index and Atherogenic Index of Plasma with the Severity of New-Onset Coronary Artery Disease in Different Glucose Metabolic States. Cardiovascular Diabetology, 23, Article No. 76. [Google Scholar] [CrossRef] [PubMed]
[38] Bittner, V., Johnson, B.D., Zineh, I., Rogers, W.J., Vido, D., Marroquin, O.C., et al. (2009) The Triglyceride/High-Density Lipoprotein Cholesterol Ratio Predicts All-Cause Mortality in Women with Suspected Myocardial Ischemia. American Heart Journal, 157, 548-555. [Google Scholar] [CrossRef] [PubMed]
[39] Won, K., Jang, M., Park, E.J., Park, H., Heo, R., Han, D., et al. (2020) Atherogenic Index of Plasma and the Risk of Advanced Subclinical Coronary Artery Disease Beyond Traditional Risk Factors: An Observational Cohort Study. Clinical Cardiology, 43, 1398-1404. [Google Scholar] [CrossRef] [PubMed]
[40] Chang, H., Lin, F.Y., Lee, S., et al. (2018) Coronary Atherosclerotic Precursors of Acute Coronary Syndromes. Journal of the American College of Cardiology, 71, 2511-2522.
[41] Fernández-Macías, J.C., Ochoa-Martínez, A.C., Varela-Silva, J.A. and Pérez-Maldonado, I.N. (2019) Atherogenic Index of Plasma: Novel Predictive Biomarker for Cardiovascular Illnesses. Archives of Medical Research, 50, 285-294. [Google Scholar] [CrossRef] [PubMed]
[42] Zhan, Y., Xu, T. and Tan, X. (2016) Two Parameters Reflect Lipid-Driven Inflammatory State in Acute Coronary Syndrome: Atherogenic Index of Plasma, Neutrophil-Lymphocyte Ratio. BMC Cardiovascular Disorders, 16, Article No. 96. [Google Scholar] [CrossRef] [PubMed]
[43] Liu, T., Liu, J., Wu, Z., Lv, Y. and Li, W. (2021) Predictive Value of the Atherogenic Index of Plasma for Chronic Total Occlusion before Coronary Angiography. Clinical Cardiology, 44, 518-525. [Google Scholar] [CrossRef] [PubMed]
[44] Süleymanoğlu, M., Rencüzoğulları, İ., Karabağ, Y., Çağdaş, M., Yesin, M., Gümüşdağ, A., et al. (2020) The Relationship between Atherogenic Index of Plasma and No-Reflow in Patients with Acute ST-Segment Elevation Myocardial Infarction Who Underwent Primary Percutaneous Coronary Intervention. The International Journal of Cardiovascular Imaging, 36, 789-796. [Google Scholar] [CrossRef] [PubMed]
[45] Dobiasova, M. (2006) [AIP—Atherogenic Index of Plasma as a Significant Predictor of Cardiovascular Risk: From Research to Practice]. Vnitrní Lékařství, 52, 64-71.
[46] Tan, M.H., Johns, D. and Glazer, N.B. (2004) Pioglitazone Reduces Atherogenic Index of Plasma in Patients with Type 2 Diabetes. Clinical Chemistry, 50, 1184-1188. [Google Scholar] [CrossRef] [PubMed]
[47] Zhu, X., Deng, F. and Lei, S. (2015) Meta-analysis of Atherogenic Index of Plasma and Other Lipid Parameters in Relation to Risk of Type 2 Diabetes Mellitus. Primary Care Diabetes, 9, 60-67. [Google Scholar] [CrossRef] [PubMed]
[48] Nwagha, U.I., Ikekpeazu, E.J., Ejezie, F.E., et al. (2010) Atherogenic Index of Plasma as Useful Predictor of Cardiovascular Risk among Postmenopausal Women in Enugu, Nigeria. African Health Sciences, 10, 248-252.
[49] Ni, W., Zhou, Z., Liu, T., Wang, H., Deng, J., Liu, X., et al. (2017) Gender-and Lesion Number-Dependent Difference in “Atherogenic Index of Plasma” in Chinese People with Coronary Heart Disease. Scientific Reports, 7, Article No. 13207. [Google Scholar] [CrossRef] [PubMed]
[50] Akbas, E.M., Timuroglu, A., Ozcicek, A., et al. (2014) Association of Uric Acid, Atherogenic Index of Plasma and Albuminuria in Diabetes Mellitus. International Journal of Clinical and Experimental Medicine, 7, 5737-5743.
[51] Barylski, M., P. Mikhailidis, D., Ciebiada, M., Rysz, J. and Banach, M. (2011) Gender Differences in the Treatment of Ischemic Heart Disease. Current Pharmaceutical Design, 17, 1059-1069. [Google Scholar] [CrossRef] [PubMed]
[52] Anagnostis, P., Stevenson, J.C., Crook, D., Johnston, D.G. and Godsland, I.F. (2016) Effects of Gender, Age and Menopausal Status on Serum Apolipoprotein Concentrations. Clinical Endocrinology, 85, 733-740. [Google Scholar] [CrossRef] [PubMed]
[53] Okan, T., Doruk, M., Ozturk, A., Topaloglu, C., Dogdus, M. and Yilmaz, M.B. (2024) Evaluation of Plasma Atherogenic Index, Triglyceride-Glucose Index and Other Lipid Ratios as Predictive Biomarkers of Coronary Artery Disease in Different Age Groups. Diagnostics, 14, Article 1495. [Google Scholar] [CrossRef] [PubMed]
[54] Onat, A., Can, G., Kaya, H. and Hergenç, G. (2010) “Atherogenic Index of Plasma” (log10 Triglyceride/High-Density Lipoprotein-Cholesterol) Predicts High Blood Pressure, Diabetes, and Vascular Events. Journal of Clinical Lipidology, 4, 89-98. [Google Scholar] [CrossRef] [PubMed]
[55] Wu, T., Gao, Y., Zheng, Y., Ma, Y. and Xie, X. (2018) Atherogenic Index of Plasma (AIP): A Novel Predictive Indicator for the Coronary Artery Disease in Postmenopausal Women. Lipids in Health and Disease, 17, Article No. 197. [Google Scholar] [CrossRef] [PubMed]
[56] 戴宇翔, 张抒扬, 田然, 等. 早发冠心病的临床特点研究[J]. 中华心血管病杂志, 2008, 36(7): 586-589.
[57] Nansseu, J.R.N., Ama Moor, V.J., Nouaga, M.E.D., Zing-Awona, B., Tchanana, G. and Ketcha, A. (2016) Atherogenic Index of Plasma and Risk of Cardiovascular Disease among Cameroonian Postmenopausal Women. Lipids in Health and Disease, 15, Article No. 49. [Google Scholar] [CrossRef] [PubMed]
[58] Aydınyılmaz, F., Özbeyaz, N.B., Guliyev, İ., Algül, E., Şahan, H.F. and Kalkan, K. (2023) Effect of Atherogenic Index of Plasma on Pre-Percutaneous Coronary Intervention Thrombolysis in Myocardial Infarction Flow in Patients with ST Elevation Myocardial Infarction. Angiology, 75, 841-848. [Google Scholar] [CrossRef] [PubMed]
[59] Khosravi, A., Sadeghi, M., Farsani, E.S., Danesh, M., Heshmat-Ghahdarijani, K., Roohafza, H., et al. (2022) Atherogenic Index of Plasma: A Valuable Novel Index to Distinguish Patients with Unstable Atherogenic Plaques. Journal of Research in Medical Sciences, 27, 45. [Google Scholar] [CrossRef] [PubMed]
[60] Karadag, M.K. and Yildirim, E. (2019) Relationship of Atherogenic Index of Plasma and Mean Platelet Volume with Ejection Fraction in Ischemic and Nonischemic HEART failure. Biomarkers in Medicine, 13, 175-183. [Google Scholar] [CrossRef] [PubMed]
[61] Shen, S., Lu, Y., Qi, H., Li, F., Shen, Z., Wu, L., et al. (2016) Association between Ideal Cardiovascular Health and the Atherogenic Index of Plasma. Medicine, 95, e3866. [Google Scholar] [CrossRef] [PubMed]