实验室指标在儿童肺炎支原体肺炎严重程度预测中的研究进展

Advances in Laboratory Markers for Predicting Severity of Pediatric Mycoplasma pneumoniae Pneumonia

摘要: 肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia, MPP)是儿科常见疾病，准确预测其严重程度对于临床治疗至关重要。本综述将重点探讨实验室指标在儿童MPP严重程度预测中的研究进展。通过分析C反应蛋白、降钙素原、红细胞沉降率等多种传统实验室指标和近年来关注的淋巴细胞亚群、细胞因子、趋化因子等新兴指标，并结合中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值、全身免疫炎症指数及C反应蛋白与白蛋白比值等易获得的实验室比值指标，揭示它们反映炎症反应及疾病严重程度中的价值。文中综合了这些指标的临床意义及其在儿童重症MPP中的应用价值。旨在为临床医生提供全面的实验室指标参考，以支持个体化诊疗决策。

Abstract: Mycoplasma pneumoniae pneumonia (MPP) is a common pediatric disease, where accurate prediction of disease severity is crucial for clinical management. This review focuses on recent advancements in laboratory indicators for predicting MPP severity in children. Through comprehensive analysis of both conventional markers (C-reactive protein, procalcitonin, erythrocyte sedimentation rate) and emerging biomarkers (lymphocyte subsets, cytokines, chemokines), combined with clinically accessible ratio parameters (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, and C-reactive protein-to-albumin ratio), we highlight their value in reflecting inflammatory responses and disease progression. The clinical implications of these indicators are systematically evaluated, particularly their applications in pediatric severe MPP cases. This synthesis aims to provide clinicians with a multi-dimensional laboratory reference framework to support personalized clinical decision-making and risk stratification strategies.