湿疹与慢性阻塞性肺病、肺癌和特发性肺纤维化的因果关系——一项孟德尔随机化分析
Causal Relationships between Eczema and Chronic Obstructive Pulmonary Disease, Lung Cancer, and Idiopathic Pulmonary Fibrosis—A Mendelian Randomization Analysis
DOI: 10.12677/acm.2025.154971, PDF,   
作者: 王子成, 卢前程, 崔紫程：青岛大学青岛医学院，山东 青岛；徐荣建*：青岛大学附属医院胸外科，山东 青岛
关键词: 湿疹；特发性皮炎；COPD；肺癌；IPF；孟德尔随机化；因果推断；Eczema； Atopic Dermatitis； COPD； Lung Cancer； IPF； Mendelian Randomization； Causal Inference
摘要: 目的：基于孟德尔随机化研究方法探究湿疹与慢性阻塞性肺病(chronic obstructive pulmonary disease, COPD)、肺癌和特发性肺纤维化(idiopathic pulmonary fibrosis, IPF)之间的因果关系。方法：基于孟德尔随机化的基本假设，通过逆方差加权法(IVW)、加权中位数法和MR-Egger回归法探寻湿疹与COPD、肺癌和IPF的因果关系。使用Cochran’s Q检验、MR-Egger回归截距法和留一法进行敏感性分析。结果：逆方差加权法作为主要分析方法，其分析结果显示，湿疹与COPD (OR = 1.279, 95%CI: 1. 168~1.401, P = 1.21*10−7)和IPF (OR = 1.262, 95%CI: 1.026~1.553, P = 0.0277)存在因果关系。没有证据可以证明湿疹与肺腺癌(OR = 1.022, 95%CI: 0.956~1.093, P = 0.516)、小细胞肺癌(OR = 0.976, 95%CI: 0.843~1.131, P = 0.747)和鳞状细胞癌(OR = 1.107, 95%CI, 0.933~1.108, P = 0.706)之间存在因果关系。结论：湿疹在COPD与IPF发病中可能发挥作用，而没有证据证明湿疹在肺癌(腺癌、小细胞癌、鳞状细胞癌)的发病中发挥作用。
Abstract: Objective: To investigate the causal relationships between eczema and chronic obstructive pulmonary disease (COPD), lung cancer, and idiopathic pulmonary fibrosis (IPF) using Mendelian randomization (MR) analysis. Methods: Based on the fundamental assumptions of MR, the inverse-variance weighted (IVW) method, weighted median method, and MR-Egger regression were employed to explore the causal relationships between eczema and COPD, lung cancer, and IPF. Sensitivity analyses were conducted using Cochran’s Q test, MR-Egger intercept test, and leave-one-out analysis. Results: The IVW method, as the primary analytical approach, revealed significant causal relationships between eczema and COPD (OR = 1.279, 95%CI: 1.168~1.401, P = 1.21 × 10−7) and IPF (OR = 1.262, 95%CI: 1.026~1.553, P = 0.0277). However, no evidence supported causal relationships between eczema and lung adenocarcinoma (OR = 1.022, 95%CI: 0.956~1.093, P = 0.516), small cell lung cancer (OR = 0.976, 95%CI: 0.843~1.131, P = 0.747), or squamous cell carcinoma (OR = 1.107, 95%CI: 0.933~1.108, P = 0.706). Conclusion: Eczema may play a role in the pathogenesis of COPD and IPF, but no evidence suggests its involvement in the development of lung cancer (adenocarcinoma, small cell carcinoma, or squamous cell carcinoma).
文章引用：王子成, 卢前程, 崔紫程, 徐荣建. 湿疹与慢性阻塞性肺病、肺癌和特发性肺纤维化的因果关系——一项孟德尔随机化分析[J]. 临床医学进展, 2025, 15(4): 591-600. https://doi.org/10.12677/acm.2025.154971

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