多模式眼底影像诊断急性黄斑区神经视网膜病变
Diagnosis of Acute Macular Neuroretinopathy by Multimodal Fundus Imaging
摘要: 急性黄斑区神经视网膜病变(AMN)是罕见的黄斑区视网膜神经上皮损伤的疾病，相关病例报道较少，本文结合超广角眼底照相、扫频光学相干断层扫描血管成像及自适应光学扫描激光检眼镜(AO-SLO)多模式眼底影像报道AMN病例，观察到AMN病灶中光感受器细胞的损伤特点，本文是国内首次报道AMN在AO-SLO中的表现并结合文献复习，旨在提高眼科医生对此疾病的了解。
Abstract: Acute macular neuroretinopathy (AMN) is a rare disease characterized by the neuroepithelium lesion of macula. There have been few case reports related to it. This article reports a case of AMN based on multimodal fundus imaging including ultra-wide field scan laser ophthalmoscope, swept-source optical coherence tomography angiography, and adaptive optics scanning laser ophthalmoscope (AO-SLO). AO-SLO could observe the damage characteristics of photoreceptor cells in AMN lesions in vivo at the cellular level. This is the first domestic report on the manifestation of AMN assessed using AO-SLO, combined with a literature review, aiming to enhance ophthalmologists’ understanding of this rare disease.
文章引用：陈莺, 崔红光. 多模式眼底影像诊断急性黄斑区神经视网膜病变[J]. 临床医学进展, 2025, 15(4): 725-731. https://doi.org/10.12677/acm.2025.154988

参考文献

[1] Bos, P.J.M. and Deutman, A.F. (1975) Acute Macular Neuroretinopathy. American Journal of Ophthalmology, 80, 573-584. [Google Scholar] [CrossRef] [PubMed]
[2] Feigl, B. and Haas, A. (2000) Optical Coherence Tomography (OCT) in Acute Macular Neuroretinopathy. Acta Ophthalmologica Scandinavica, 78, 714-716. [Google Scholar] [CrossRef] [PubMed]
[3] Bhavsar, K.V., Lin, S., Rahimy, E., Joseph, A., Freund, K.B., Sarraf, D., et al. (2016) Acute Macular Neuroretinopathy: A Comprehensive Review of the Literature. Survey of Ophthalmology, 61, 538-565. [Google Scholar] [CrossRef] [PubMed]
[4] Yzer, S., Freund, K.B. and Engelbert, M. (2012) Imaging in the Diagnosis and Management of Acute Macular Neuroretinopathy. International Ophthalmology Clinics, 52, 269-273. [Google Scholar] [CrossRef] [PubMed]
[5] Hirooka, K., Saito, W., Noda, K. and Ishida, S. (2014) Enhanced-Depth Imaging Optical Coherence Tomography and Laser Speckle Flowgraphy in a Patient with Acute Macular Neuroretinopathy. Ocular Immunology and Inflammation, 22, 485-489. [Google Scholar] [CrossRef] [PubMed]
[6] Douglas, I.S. and Cockburn, D.M. (2003) Acute Macular Neuroretinopathy. Clinical and Experimental Optometry, 86, 121-126. [Google Scholar] [CrossRef] [PubMed]
[7] 姜利斌, 魏文斌, 王光璐. 急性黄斑区神经视网膜病变[J]. 中国实用眼科杂志, 2006, 24(3): 240-243.
[8] Fawzi, A.A., Pappuru, R.R., Sarraf, D., Le, P.P., McCannel, C.A., Sobrin, L., et al. (2012) Acute Macular Neuroretinopathy: Long-Term In-Sights Revealed by Multimodal Imaging. Retina, 32, 1500-1513. [Google Scholar] [CrossRef] [PubMed]
[9] Sieving, P.A., Fishman, G.A., Salzano, T. and Rabb, M.F. (1984) Acute Macular Neuroretinopathy: Early Receptor Potential Change Suggests Photoreceptor Pathology. British Journal of Ophthalmology, 68, 229-234. [Google Scholar] [CrossRef] [PubMed]
[10] Browning, A.C. (2003) The Multifocal Electroretinogram in Acute Macular Neuroretinopathy. Archives of Ophthalmology, 121, 1506-1507. [Google Scholar] [CrossRef] [PubMed]
[11] Maturi, R.K. (2003) Multifocal Electroretinographic Evaluation of Acute Macular Neuroretinopathy. Archives of Ophthalmology, 121, 1068-1069. [Google Scholar] [CrossRef] [PubMed]
[12] Yeh, S. (2011) Acute Macular Outer Retinopathy (AMOR): A Reappraisal of Acute Macular Neuroretinopathy Using Multimodality Diagnostic Testing. Archives of Ophthalmology, 129, 360-371. [Google Scholar] [CrossRef] [PubMed]
[13] 滕羽菲, 郑轶, 于旭辉, 等. 急性黄斑区神经视网膜病变的临床及OCT特征[J]. 眼科, 2016, 25(6): 391-395.
[14] Rodman, J.A., Shechtman, D.L. and Haines, K. (2014) Acute Macular Neuroretinopathy: The Evolution of the Disease through the Use of Newer Diagnostic Modalities. Clinical and Experimental Optometry, 97, 463-467. [Google Scholar] [CrossRef] [PubMed]
[15] Shroff, D., Kothari, A., Gupta, P., Sahni, T.K. and Narain, S. (2022) Hyperbaric Oxygen Therapy Combined with Immunosuppression for Acute Macular Neuroretinopathy in Systemic Lupus Erythematosus. Ocular Immunology and Inflammation, 31, 355-361. [Google Scholar] [CrossRef] [PubMed]
[16] Priluck, I.A., Buettner, H. and Robertson, D.M. (1978) Acute Macular Neuroretinopathy. American Journal of Ophthalmology, 86, 775-778. [Google Scholar] [CrossRef] [PubMed]
[17] Sarraf, D., Rahimy, E., Fawzi, A.A., Sohn, E., Barbazetto, I., Zacks, D.N., et al. (2013) Paracentral Acute Middle Maculopathy: A New Variant of Acute Macular Neuroretinopathy Associated with Retinal Capillary Ischemia. JAMA Ophthalmology, 131, 1275-1287. [Google Scholar] [CrossRef] [PubMed]
[18] 王韵澎, 燕静, 郝翔. 自适应光学在超分辨显微成像技术中的应用(内封面文章∙特邀) [J]. 红外与激光工程, 2024, 53(5): 12-27.
[19] Liang, J., Williams, D.R. and Miller, D.T. (1997) Supernormal Vision and High-Resolution Retinal Imaging through Adaptive Optics. Journal of the Optical Society of America A, 14, 2884-2892. [Google Scholar] [CrossRef] [PubMed]
[20] Kreis, J. and Carroll, J. (2024) Applications of Adaptive Optics Imaging for Studying Conditions Affecting the Fovea. Annual Review of Vision Science, 10, 239-262. [Google Scholar] [CrossRef] [PubMed]
[21] Britten-Jones, A.C., Thai, L., Flanagan, J.P.M., Bedggood, P.A., Edwards, T.L., Metha, A.B., et al. (2024) Adaptive Optics Imaging in Inherited Retinal Diseases: A Scoping Review of the Clinical Literature. Survey of Ophthalmology, 69, 51-66. [Google Scholar] [CrossRef] [PubMed]
[22] Hansen, S.O., Cooper, R.F., Dubra, A., Carroll, J. and Weinberg, D.V. (2013) Selective Cone Photoreceptor Injury in Acute Macular Neuroretinopathy. Retina, 33, 1650-1658. [Google Scholar] [CrossRef] [PubMed]
[23] Mrejen, S., Pang, C.E., Sarraf, D., Goldberg, N.R., Gallego-Pinazo, R., Klancnik, J.M., et al. (2014) Adaptive Optics Imaging of Cone Mosaic Abnormalities in Acute Macular Neuroretinopathy. Ophthalmic Surgery, Lasers and Imaging Retina, 45, 562-569. [Google Scholar] [CrossRef] [PubMed]
[24] Audo, I., Gocho, K., Rossant, F., Mohand-Saïd, S., Loquin, K., Bloch, I., et al. (2015) Functional and High-Resolution Retinal Imaging Monitoring Photoreceptor Damage in Acute Macular Neuroretinopathy. Graefe’s Archive for Clinical and Experimental Ophthalmology, 254, 855-864. [Google Scholar] [CrossRef] [PubMed]
[25] Kadomoto, S., Muraoka, Y., Ooto, S. and Tsujikawa, A. (2023) Structural Changes in Acute Macular Neuroretinopathy Revealed with Adaptive Optics Optical Coherence Tomography. JAMA Ophthalmology, 141, 400-402. [Google Scholar] [CrossRef] [PubMed]

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