微通道显微镜手术在脊柱脊髓疾病中的应用
Application of Microscopic Microchannel Surgery in Spinal and Spinal Cord Diseases
DOI: 10.12677/acm.2025.1541010, PDF,    科研立项经费支持
作者: 刘 伟, 李 锋*:山东第一医科大学(山东省医学科学院),第一临床医学院,山东 济南;山东第一医科大学第一附属医院(山东省千佛山医院),神经外科,山东 济南
关键词: 微通道显微镜手术管状牵开器微创手术脊柱退行性疾病椎管内肿瘤Microscopic Microchannel Surgery (MMS) Tubular Retractor Minimally Invasive Surgery Spinal Degenerative Diseases Intradural Tumors
摘要: 脊柱脊髓疾病作为全球重大健康负担,其后遗症高风险与复杂治疗需求推动了微创技术的发展。微通道显微镜手术(Microscopic Microchannel Surgery, MMS)通过结合微创通道技术与显微成像系统,实现了精准、低创伤的脊柱外科干预。本文系统描述了微通道显微镜手术在脊柱退行性疾病(如腰椎间盘突出、椎管狭窄)及椎管内肿瘤治疗中的应用,重点剖析其技术原理、临床优势与局限性。研究表明,微通道显微镜手术通过小切口与逐级扩张通道,显著减少术中组织损伤与术后并发症,尤其适用于老年患者及高风险人群;在颈椎病领域,改良术式(如AMTc、AETc)进一步拓展了其适应症,兼顾生物力学保留与病变精准切除。尽管微通道显微镜手术在腰椎与椎管肿瘤治疗中表现出与开放手术相当的疗效,但其技术门槛高、操作空间有限等问题仍需突破。未来研究应聚焦适应症扩展、脊柱稳定性及长期疗效验证,以推动脊柱微创外科的精准化与个体化发展。
Abstract: Spinal and spinal cord diseases are a significant global health burden. The high risk of sequelae and complex treatment requirements have driven the development of minimally invasive techniques. Microscopic Microchannel Surgery (MMS), which combines minimally invasive channel technology with a microimaging system, has enabled precise and minimally traumatic spinal interventions. This article systematically describes the application of MMS in the treatment of spinal degenerative diseases (such as lumbar disc herniation and spinal canal stenosis) and intradural tumors, with a focus on its technical principles, clinical advantages, and limitations. Studies have shown that MMS, through small incisions and gradual expansion of the channel, significantly reduces intraoperative tissue damage and postoperative complications, making it particularly suitable for elderly patients and high-risk populations. In the field of cervical spondylosis, modified surgical procedures (such as AMTc and AETc) have further expanded its indications, balancing the retention of biomechanics and precise removal of lesions. Although MMS has demonstrated comparable efficacy to open surgery in the treatment of lumbar and intradural tumors, its high technical threshold and limited operating space still need to be overcome. Future research should focus on expanding indications, verifying spinal stability, and long-term efficacy to promote the precision and individualization of minimally invasive spinal surgery.
文章引用:刘伟, 李锋. 微通道显微镜手术在脊柱脊髓疾病中的应用[J]. 临床医学进展, 2025, 15(4): 896-903. https://doi.org/10.12677/acm.2025.1541010

参考文献

[1] Quadri, S.A., Farooqui, M., Ikram, A., Zafar, A., Khan, M.A., Suriya, S.S., et al. (2018) Recent Update on Basic Mechanisms of Spinal Cord Injury. Neurosurgical Review, 43, 425-441. [Google Scholar] [CrossRef] [PubMed]
[2] Vos, T., Lim, S.S., Abbafati, C., Abbas, K.M., Abbasi, M., Abbasifard, M., et al. (2020) Global Burden of 369 Diseases and Injuries in 204 Countries and Territories, 1990-2019: A Systematic Analysis for the Global Burden of Disease Study 2019. The Lancet, 396, 1204-1222. [Google Scholar] [CrossRef] [PubMed]
[3] Crispo, J.A.G., Kuramoto, L.K. and Cragg, J.J. (2023) Global Burden of Spinal Cord Injury: Future Directions. The Lancet Neurology, 22, 976-978. [Google Scholar] [CrossRef] [PubMed]
[4] Chou, R., Qaseem, A., Snow, V., Casey, D., Cross, J.T., Shekelle, P., et al. (2007) Diagnosis and Treatment of Low Back Pain: A Joint Clinical Practice Guideline from the American College of Physicians and the American Pain Society. Annals of Internal Medicine, 147, 478-491. [Google Scholar] [CrossRef] [PubMed]
[5] Zuo, G., Gao, T., Xue, B., Gu, C., Yan, Y., Zhang, Y., et al. (2019) Assessment of the Efficacy of Acupuncture and Chiropractic on Treating Cervical Spondylosis Radiculopathy: A Systematic Review and Meta-Analysis. Medicine, 98, e17974. [Google Scholar] [CrossRef] [PubMed]
[6] Karsy, M. and Hawryluk, G. (2019) Modern Medical Management of Spinal Cord Injury. Current Neurology and Neuroscience Reports, 19, Article No. 65. [Google Scholar] [CrossRef] [PubMed]
[7] Chikuda, H., Koyama, Y., Matsubayashi, Y., Ogata, T., Ohtsu, H., Sugita, S., et al. (2021) Effect of Early vs Delayed Surgical Treatment on Motor Recovery in Incomplete Cervical Spinal Cord Injury with Preexisting Cervical Stenosis: A Randomized Clinical Trial. JAMA Network Open, 4, e2133604. [Google Scholar] [CrossRef] [PubMed]
[8] Williams, J., D’Amore, P., Redlich, N., Darlow, M., Suwak, P., Sarkovich, S., et al. (2022) Degenerative Cervical Myelopathy: Evaluation and Management. Orthopedic Clinics of North America, 53, 509-521. [Google Scholar] [CrossRef] [PubMed]
[9] Vaishnav, A.S., Othman, Y.A., Virk, S.S., Gang, C.H. and Qureshi, S.A. (2019) Current State of Minimally Invasive Spine Surgery. Journal of Spine Surgery, 5, S2-S10. [Google Scholar] [CrossRef] [PubMed]
[10] Foley, K.T. and Lefkowitz, M.A. (2002) Advances in Minimally Invasive Spine Surgery. Clinical Neurosurgery, 49, 499-517.
[11] Zhang, C., Li, D., Wang, C. and Yan, X. (2016) Cervical Endoscopic Laminoplasty for Cervical Myelopathy. Spine, 41, B44-B51. [Google Scholar] [CrossRef] [PubMed]
[12] Tian, W. and Boden, S.D. (2016) Minimally Invasive Spine Surgery (MISS) in China. Spine, 41, B1. [Google Scholar] [CrossRef] [PubMed]
[13] Xu, J., Liu, C., Lin, Y. and Luo, F. (2018) Microscopic Minimally Invasive Keyhole Technique for Surgical Resection of Spinal Dumbbell Tumors. World Neurosurgery, 109, e110-e117. [Google Scholar] [CrossRef] [PubMed]
[14] Cervellini, P., Luca, G.P., Mazzetto, M. and Colombo, F. (n.d.) Micro-Endoscopic-Discectomy (MED) for Far Lateral Disc Herniation in the Lumbar Spine. Technical Note. In: Alexandre, A., Bricolo, A. and Millesi, H., Eds., Advanced Peripheral Nerve Surgery and Minimal Invasive Spinal Surgery, Springer, 99-101. [Google Scholar] [CrossRef] [PubMed]
[15] 林国中, 吴超, 司雨, 马长城, 杨军. 微通道辅助经椎旁肌间隙入路显微手术切除胸腰椎椎旁肿瘤[J]. 中国微创外科杂志, 2021(1): 61-64.
[16] Palmer, S., Turner, R. and Palmer, R. (2002) Bilateral Decompressive Surgery in Lumbar Spinal Stenosis Associated with Spondylolisthesis: Unilateral Approach and Use of a Microscope and Tubular Retractor System. Neurosurgical Focus, 13, E4. [Google Scholar] [CrossRef] [PubMed]
[17] Kulkarni, A.G., Das, S. and Kunder, T.S. (2019) Are There Differences between Patients with Extreme Stenosis and Non-Extreme Stenosis in Terms of Pain, Function or Complications after Spinal Decompression Using a Tubular Retractor System? Clinical Orthopaedics & Related Research, 478, 348-356. [Google Scholar] [CrossRef] [PubMed]
[18] Zhang, A.S., Xu, A., Ansari, K., Hardacker, K., Anderson, G., Alsoof, D., et al. (2023) Lumbar Disc Herniation: Diagnosis and Management. The American Journal of Medicine, 136, 645-651. [Google Scholar] [CrossRef] [PubMed]
[19] Mao, L., Wang, K., Zhu, W., Shen, Z., Zhang, X., Xie, Z., et al. (2024) Repeat Surgery after Percutaneous Endoscopic Lumbar Discectomy for Adolescent Lumbar Disc Herniation: A Multicenter Observational Study. Orthopaedic Surgery, 16, 1336-1343. [Google Scholar] [CrossRef] [PubMed]
[20] Rasouli, M.R., Rahimi-Movaghar, V., Shokraneh, F., Moradi-Lakeh, M. and Chou, R. (2014) Minimally Invasive Discectomy versus Microdiscectomy/Open Discectomy for Symptomatic Lumbar Disc Herniation. Cochrane Database of Systematic Reviews, 2014, CD010328. [Google Scholar] [CrossRef] [PubMed]
[21] Li, W., Yan, Q. and Cong, L. (2021) Comparison of Endoscopic Discectomy versus Non-Endoscopic Discectomy for Symptomatic Lumbar Disc Herniation: A Systematic Review and Meta-analysis. Global Spine Journal, 12, 1012-1026. [Google Scholar] [CrossRef] [PubMed]
[22] Yu, P., Qiang, H., Zhou, J. and Huang, P. (2019) Percutaneous Transforaminal Endoscopic Discectomy versus Micro-Endoscopic Discectomy for Lumbar Disc Herniation. Medical Science Monitor, 25, 2320-2328. [Google Scholar] [CrossRef] [PubMed]
[23] Meng, H., Su, N., Lin, J. and Fei, Q. (2023) Comparative Efficacy of Unilateral Biportal Endoscopy and Micro-Endoscopic Discectomy in the Treatment of Degenerative Lumbar Spinal Stenosis: A Systematic Review and Meta-Analysis. Journal of Orthopaedic Surgery and Research, 18, Article No. 814. [Google Scholar] [CrossRef] [PubMed]
[24] Madhok, R. and Kanter, A.S. (2010) Extreme-Lateral, Minimally Invasive, Transpsoas Approach for the Treatment of Far-Lateral Lumbar Disc Herniation. Journal of Neurosurgery: Spine, 12, 347-350. [Google Scholar] [CrossRef] [PubMed]
[25] Yeom, J.S., Kim, K.H., Hong, S.W., Park, K., Chang, B., Lee, C., et al. (2008) A Minimally Invasive Technique for L5-S1 Intraforaminal Disc Herniations: Microdiscectomy with a Tubular Retractor via a Contralateral Approach. Journal of Neurosurgery: Spine, 8, 193-198. [Google Scholar] [CrossRef] [PubMed]
[26] Zhao, L.J., Jiang, W.Y., Ma, W.H., Xu, R.M. and Sun, S.H. (2011) Micro-Endoscopic Discectomy for the Treatment of Lumbar Disc Herniation in Senile Patients over Seventy Years Old. China Journal of Orthopaedics and Traumatology, 24, 811-815.
[27] Jitin, B. (2021) Cervical Spondylosis and Atypical Symptoms. Neurology India, 69, 602-603. [Google Scholar] [CrossRef] [PubMed]
[28] Theodore, N. (2020) Degenerative Cervical Spondylosis. New England Journal of Medicine, 383, 159-168. [Google Scholar] [CrossRef] [PubMed]
[29] Reddy, R.S., Tedla, J.S., Dixit, S. and Abohashrh, M. (2019) Cervical Proprioception and Its Relationship with Neck Pain Intensity in Subjects with Cervical Spondylosis. BMC Musculoskeletal Disorders, 20, Article No. 447. [Google Scholar] [CrossRef] [PubMed]
[30] Jitpakdee, K., Kotheeranurak, V., Lim, W.J. and Kim, J. (2021) Anterior Transcorporeal Approach for Cervical Metastatic Melanoma Resection Guided by O-Arm-Navigated Intraoperative Computed Tomography. Operative Neurosurgery, 22, e7-e11. [Google Scholar] [CrossRef] [PubMed]
[31] Liu, Y., Suvithayasiri, S., Van Isseldyk, F., Kotheeranurak, V., Jitpakdee, K., Choi, K., et al. (2024) Evaluating the Effectiveness of the Transcorporeal Approach in Minimally Invasive Spine Surgery for Cervical Spinal Disease: A Comprehensive Review and Technical Insights. BMC Surgery, 24, Article No. 311. [Google Scholar] [CrossRef] [PubMed]
[32] Dang, L., Liu, X., Dang, G., Jiang, L., Wei, F., Yu, M., et al. (2015) Primary Tumors of the Spine: A Review of Clinical Features in 438 Patients. Journal of Neuro-Oncology, 121, 513-520. [Google Scholar] [CrossRef] [PubMed]
[33] Iacoangeli, M., Gladi, M., Di Rienzo, Dobran, M., Alvaro, L., Nocchi, N., et al. (2012) Minimally Invasive Surgery for Benign Intradural Extramedullary Spinal Meningiomas: Experience of a Single Institution in a Cohort of Elderly Patients and Review of the Literature. Clinical Interventions in Aging, 7, 557-564. [Google Scholar] [CrossRef] [PubMed]
[34] Dreghorn, C.R., Newman, R.J., Hardy, G.J. and Dickson, R.A. (1990) Primary Tumors of the Axial Skeleton. Experience of the Leeds Regional Bone Tumor Registry. Spine, 15, 137-140. [Google Scholar] [CrossRef] [PubMed]
[35] Mannion, R.J., Nowitzke, A.M., Efendy, J. and Wood, M.J. (2011) Safety and Efficacy of Intradural Extramedullary Spinal Tumor Removal Using a Minimally Invasive Approach. Operative Neurosurgery, 68, ons208-ons216. [Google Scholar] [CrossRef] [PubMed]
[36] Kelley, B.J., Johnson, M.H., Vortmeyer, A.O., Smith, B.G. and Abbed, K.M. (2012) Two-Level Thoracic Pedicle Subtraction Osteotomy for Progressive Post-Laminectomy Kyphotic Deformity Following Resection of an Unusual Thoracolumbar Intradural Extramedullary Tumor. Journal of Neurosurgery: Pediatrics, 10, 334-339. [Google Scholar] [CrossRef] [PubMed]
[37] Tanaka, M., Sugimoto, Y., Misawa, H., Takigawa, T., Kunisada, T. and Ozaki, T. (2012) Segmental Pedicle Screw Fixation for a Scoliosis Patient with Post-Laminectomy and Post-Irradiation Thoracic Kyphoscoliosis of Spinal Astrocytoma. Acta Medica Okayama, 66, 363-368.
[38] Lu, D.C., Dhall, S.S. and Mummaneni, P.V. (2010) The Transspinous Mini-Open Approach for Resection of Intradural Spinal Neoplasms: Cadaveric Feasibility Study and Report of 3 Clinical Cases. World Neurosurgery, 74, 195-199. [Google Scholar] [CrossRef] [PubMed]
[39] Afathi, M., Peltier, E., Adetchessi, T., Graillon, T., Dufour, H. and Fuentes, S. (2015) Minimally Invasive Transmuscular Approach for the Treatment of Benign Intradural Extramedullary Spinal Cord Tumours: Technical Note and Results. Neurochirurgie, 61, 333-338. [Google Scholar] [CrossRef] [PubMed]
[40] Tredway, T.L., Santiago, P., Hrubes, M.R., Song, J.K., Christie, S.D. and Fessler, R.G. (2006) Minimally Invasive Resection of Intradural-Extramedullary Spinal Neoplasms. Operative Neurosurgery, 58, ONS-52-ONS-58. [Google Scholar] [CrossRef] [PubMed]
[41] Haji, F.A., Cenic, A., Crevier, L., Murty, N. and Reddy, K. (2011) Minimally Invasive Approach for the Resection of Spinal Neoplasm. Spine, 36, E1018-E1026. [Google Scholar] [CrossRef] [PubMed]
[42] Fu, C., Zhuang, Y., Chen, C., Cai, G., Zhang, H., Zhao, W., et al. (2016) Spontaneous Spinal Epidural Hematoma Management with Minimally Invasive Surgery through Tubular Retractors. A Case Report and Review of the Literature. Medicine, 95, e3906. [Google Scholar] [CrossRef] [PubMed]
[43] Boukebir, M.A., Berlin, C.D., Navarro-Ramirez, R., Heiland, T., Schöller, K., Rawanduzy, C., et al. (2017) Ten-Step Minimally Invasive Spine Lumbar Decompression and Dural Repair through Tubular Retractors. Operative Neurosurgery, 13, 232-245. [Google Scholar] [CrossRef] [PubMed]
[44] Kulkarni, A.G., Bassi, A. and Dhruv, A. (2014) Microendoscopic Lumbar Discectomy: Technique and Results of 188 Cases. Indian Journal of Orthopaedics, 48, 81-87. [Google Scholar] [CrossRef] [PubMed]