阿托西班联合宫颈环扎术后对宫颈机能不全的作用及母婴结局影响

The Effects of Atosiban Combined with Cervical Cerclage on Cervical Insufficiency and the Impact on Maternal and Infant Outcomes

摘要: 宫颈机能不全(CI)是中晚期妊娠流产及早产的常见病因，宫颈环扎术虽能提升宫颈支撑力，部分患者术后仍面临宫颈扩张难题。阿托西班作为子宫收缩素受体拮抗剂，可有效抑制宫缩，与宫颈环扎术联合应用成为研究焦点。其能通过竞争受体发挥抑制宫缩、预防早产及治疗宫缩过强等作用，且对母体其他器官影响轻微。鉴于宫颈机能不全病因与发病机制不明，宫颈环扎术难以阻断子宫收缩压力传导，该联合治疗方案在抑制宫颈扩张、改善临床疗效及母婴结局等方面的作用机制与效果，对妇产科临床实践具有重要参考价值。

Abstract: Cervical incompetence (CI) is a common cause of miscarriage and premature birth in the second and third trimesters of pregnancy. Cervical cerclage can improve cervical support, but some patients still experience cervical dilation after the surgery. As a uterine contraction inhibitor, atosiban, when used in combination with cervical cerclage, has become a research hotspot. Atosiban is an oxytocin receptor antagonist that inhibits uterine contractions by competing for receptors. It has functions such as inhibiting uterine contractions, preventing premature birth, and treating excessive uterine contractions, and has little impact on other maternal organs. The causes and pathogenesis of cervical incompetence remain unclear. Cervical cerclage cannot completely block the pressure transmission caused by uterine contractions. Atosiban, as a uterine contraction inhibitor, is of great significance in the combined application. This article explores various aspects of this combined treatment, including its mechanism of inhibiting cervical dilation, clinical efficacy, and impact on maternal and neonatal outcomes, providing a reference for clinical practice in obstetrics and gynecology.