线粒体自噬与脂肪酸氧化在代谢性肥胖中的作用
The Role of Mitochondrial Autophagy and Fatty Acid Oxidation in Metabolic Obesity
DOI: 10.12677/acm.2025.1541098, PDF,    科研立项经费支持
作者: 田 苗：黑龙江中医药大学实验实训中心，黑龙江 哈尔滨
关键词: 线粒体自噬；脂肪酸氧化；代谢性肥胖；能量代谢；细胞自噬；Mitochondrial Autophagy； Fatty Acid Oxidation； Metabolic Obesity； Energy Metabolism； Cellular Autophagy
摘要: 代谢性肥胖是现代社会中日益严重的健康问题，与多种代谢性疾病密切相关，给公共健康带来了巨大的挑战。研究发现，线粒体自噬作为细胞内自噬的一个重要过程，能够有效地维持线粒体的功能与质量，从而影响细胞的能量代谢状态。同时，脂肪酸氧化作为能量代谢的重要途径，直接参与调节能量平衡。近年来的研究表明，线粒体自噬与脂肪酸氧化之间存在着复杂的相互关系，这一关系在代谢性肥胖的发展中可能发挥着重要作用。然而，目前该领域的研究仍存在一些问题，包括对两者相互作用机制的深入理解不足以及相关临床应用的局限性。本文将系统探讨线粒体自噬与脂肪酸氧化在代谢性肥胖中的相互关系及其潜在机制，并总结最新的研究成果，旨在为未来的研究和临床干预提供理论基础。
Abstract: Metabolic obesity is an increasingly serious health problem in modern society, closely related to various metabolic diseases, and poses a huge challenge to public health. Research has found that mitochondrial autophagy, as an important process of intracellular autophagy, can effectively maintain the function and quality of mitochondria, thereby affecting the energy metabolism status of cells. Meanwhile, fatty acid oxidation, as an important pathway of energy metabolism, directly participates in regulating energy balance. Recent studies have shown that there is a complex interplay between mitochondrial autophagy and fatty acid oxidation, which may play an important role in the development of metabolic obesity. However, there are still some problems in the current research in this field, including insufficient understanding of the interaction mechanism between the two and limitations in related clinical applications. This article will systematically explore the relationship and potential mechanisms between mitochondrial autophagy and fatty acid oxidation in metabolic obesity, and summarize the latest research results, aiming to provide a theoretical basis for future research and clinical interventions.
文章引用：田苗. 线粒体自噬与脂肪酸氧化在代谢性肥胖中的作用[J]. 临床医学进展, 2025, 15(4): 1606-1614. https://doi.org/10.12677/acm.2025.1541098

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