抗中性粒细胞胞浆抗体相关性血管炎肺损伤
Antineutrophil Cytoplasmic Antibody-Associated Vasculitis-Related Lung Injury
DOI: 10.12677/acm.2025.1541102, PDF,   
作者: 何依婷*, 罗征秀#:重庆医科大学附属儿童医院呼吸科,国家儿童健康与疾病临床医学研究中心,儿童发育疾病研究教育部重点实验室,儿童感染与免疫罕见病重庆市重点实验室,重庆
关键词: ANCA相关性血管炎间质性肺疾病抗中性粒细胞胞浆抗体ANCA-Associated Vasculitis Interstitial Lung Diseases Antineutrophil Cytoplasmic Antibodies
摘要: ANCA相关性血管炎(ANCA-associated vasculitis, AAV)是一种以小血管受累为主,同时也伴有中血管受累,以坏死性小血管炎为主要病理表现并伴随着全身多系统累及的异质性自身免疫性疾病。作为全身性疾病,肺的累及是AAV最常见的受累器官之一,同时,肺受累也是AAV预后不佳的重要指标。本综述将对ANCA相关性血管炎肺损伤的流行病学、机制、临床特点、治疗进行讨论。
Abstract: ANCA-associated vasculitis (AAV) is a heterogeneous autoimmune disease with mostly small vessels involvement, but also medium vessels, and the main pathological manifestation is necrotizing small vasculitis which is accompanied with systemic multi-system involvements. As a systemic disease, the lung is one of the target organs commonly involved in AAV, which predicts increased mortality. This review discusses the epidemiology, mechanism, clinical features, and treatment of lung injury in ANCA-associated vasculitis.
文章引用:何依婷, 罗征秀. 抗中性粒细胞胞浆抗体相关性血管炎肺损伤[J]. 临床医学进展, 2025, 15(4): 1637-1648. https://doi.org/10.12677/acm.2025.1541102

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