神经调控技术在超难治性癫痫持续状态中的应用
Application of Neuromodulation Techniques in Super-Refractory Status Epilepticus
DOI: 10.12677/acm.2025.1541113, PDF,   
作者: 王 灵, 蒋 莉*：重庆医科大学附属儿童医院神经内科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿童神经发育与认知障碍重庆市重点实验室，重庆
关键词: 超难治性癫痫持续状态；神经调控技术；神经刺激；癫痫网络；疗效；Super-Refractory Status Epilepticus； Neuromodulation Techniques； Neurostimulation； Epileptic Network； Efficacy
摘要: 超难治性癫痫持续状态(super-refractory status epilepticus, SRSE)是临床急危重症，具有较高的死亡率及致残率。传统抗癫痫药物(ASMs)与麻醉剂输注疗效欠佳。近年来基于癫痫网络理论与神经电生理进展，神经调控技术逐渐成为SRSE多模态治疗的重要策略。因此，本文系统综述侵入性(迷走神经刺激、深部脑刺激、反应性神经刺激)与非侵入性(经颅磁刺激、电休克疗法、经颅直流电刺激)技术的临床证据，旨在阐明神经调控技术对SRSE的治疗效能，以指导SRSE个体化治疗策略的制定，从而提升长期生存质量。
Abstract: Super-refractory status epilepticus (SRSE) is a life-threatening neurological emergency associated with high mortality and disability rates. Traditional therapeutic approaches, including anti-epileptic drugs and anesthetic infusions, often yield suboptimal outcomes. Recent advances in epileptic network theory and neuroelectrophysiology have established neuromodulation techniques as a critical component of multimodal therapeutic strategies for SRSE. This review systematically evaluates clinical evidence for invasive techniques—vagus nerve stimulation (VNS), deep brain stimulation (DBS), and responsive neurostimulation (RNS)—and non-invasive modalities, including transcranial magnetic stimulation (TMS), electroconvulsive therapy (ECT), and transcranial direct current stimulation (tDCS). By elucidating the therapeutic efficacy of these neuromodulation approaches, we aim to guide the development of individualized treatment protocols, optimize seizure control rates and neurological functional recovery, and ultimately improve long-term quality of life for SRSE patients.
文章引用：王灵, 蒋莉. 神经调控技术在超难治性癫痫持续状态中的应用[J]. 临床医学进展, 2025, 15(4): 1720-1727. https://doi.org/10.12677/acm.2025.1541113

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