胰岛素样肽在生理状态及疾病中的作用研究进展
Research Advances on the Role of Insulin-Like Peptides in Physiological States and Diseases
摘要: 胰岛素样肽(Insulin-like Peptide, INSL)是一类进化保守、功能多样的小分子信号肽，主要功能是调控代谢和生长发育，其异常表达与隐睾症、妊娠相关疾病、糖尿病、肺癌、乳腺癌等多种疾病有关。INSL是一种多效能的激素，在生殖系统发挥重要的作用，此外，还在胃肠道、下丘脑、胰腺等组织器官参与复杂多样的病理生理调节。本文综述了INSL在生理状态及疾病中生物学功能的研究进展。
Abstract: Insulin-like Peptides (INSLs) are a class of evolutionarily conserved, functionally diverse small signaling peptides. Primarily involved in regulating metabolism and growth, their aberrant expression has been associated with various pathologies including cryptorchidism, pregnancy-related disorders, diabetes, lung cancer, and breast cancer, among others. As pleiotropic hormones, INSLs play crucial roles in the reproductive system, while also participating in complex pathophysiological regulation within the gastrointestinal tract, hypothalamus, pancreas, and other organs. This review summarizes recent advances in understanding the biological functions of INSLs under both physiological conditions and disease states.
文章引用：赵琛. 胰岛素样肽在生理状态及疾病中的作用研究进展[J]. 临床医学进展, 2025, 15(4): 1741-1747. https://doi.org/10.12677/acm.2025.1541116

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