肺炎链球菌表面蛋白逃避补体系统介导的免疫反应机制的研究进展
Advances in the Mechanism of Streptococcus Pneumoniae Surface Proteins Evading the Immune Response Mediated by the Complement System
DOI: 10.12677/acm.2025.1541169, PDF,   
作者: 万学每, 刘成军*：重庆医科大学附属儿童医院重症医学科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿童代谢与炎症性疾病重庆市重点实验室，重庆
关键词: 肺炎链球菌；补体系统；免疫逃避；表面蛋白；Streptococcus Pneumoniae； Complement System； Immune Evasion； Pneumococcal Surface Proteins
摘要: 尽管抗生素及疫苗的使用降低了肺炎链球菌肺炎的发病率及病死率，肺炎链球菌性疾病仍然是全球5岁以下儿童感染和死亡的常见原因。补体系统对肺炎链球菌的免疫防御相关研究众多，研究表明肺炎球菌表面蛋白在限制补体介导的免疫系统的溶菌过程和吞噬过程中发挥了重要的作用。本文综述了肺炎链球菌表面蛋白为逃避机体补体系统介导的免疫反应的机制，为后续相关研究开展提供借鉴。
Abstract: The widespread use of antibiotics and vaccines has reduced the incidence and mortality of Streptococcus pneumonia, yet, pneumococcal disease remains a common cause of infection and death in children under 5 years old. Studies related to the immune defense of the complement system against streptococcus pneumoniae are numbered, and show that pneumococcal surface proteins play an important role in limiting complement mediated opsonization and phagocytosis of the immune system. This review focuses on the mechanism of Streptococcus pneumoniae surface proteins evading the immune response mediated by the complement system, providing a reference for the future related research.
文章引用：万学每, 刘成军. 肺炎链球菌表面蛋白逃避补体系统介导的免疫反应机制的研究进展[J]. 临床医学进展, 2025, 15(4): 2186-2192. https://doi.org/10.12677/acm.2025.1541169

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