PAICS在胃癌中的表达及临床意义
Expression and Clinical Significance of PAICS in Gastric Cancer
DOI: 10.12677/acm.2025.1541170, PDF,   
作者: 于 帅, 李启信*：安徽医科大学附属巢湖医院胃肠外科，安徽 合肥
关键词: 胃癌；PAICS；免疫浸润；预后；Gastric Cancer； PAICS； Immune Infiltration； Prognosis
摘要: 目的：通过生物信息学方法研究PAICS对胃癌患者预后影响及其临床意义。方法：应用Kaplan-Meier (https://kmplot.com/analysis/)网站数据库研究PAICS表达与胃癌患者临床预后的相关性。使用TIMER2.0数据库、UALCAN数据库阐明PAICS在胃癌组织中的表达与免疫细胞浸润和相关基因标记物的相关性。结果：PAICS在多种癌症中表达水平高于正常组织，且具有统计学意义(P < 0.001)，其中包括BLCA (膀胱尿路上皮癌)、BRCA (乳腺浸润性癌)、COAD (结肠癌)、ESCA (食管癌)、LIHC (肝细胞癌)、LUAD (肺腺癌)、LUSC (肺鳞状细胞癌)、PRAD (前列腺癌)、STAD (胃癌)、THCA (甲状腺癌)、UCEC (子宫内膜癌)。提示PAICS的高表达与胃癌预后不良有关。PAICS表达与胃癌免疫细胞(B细胞、CD4+T细胞、CD8+T细胞、中性粒细胞、巨噬细胞和树突状细胞)浸润呈负相关(P < 0.01)；胃癌中PAICS表达水平与多数免疫细胞标志物相关。结论：PAICS显著影响胃癌预后，可以作为胃癌预后相关生物标志物。
Abstract: Objective: This study investigates the prognostic impact and clinical significance of PAICS in gastric cancer patients through bioinformatics approaches. Methods: The Kaplan-Meier (https://kmplot.com/analysis/) database was used to study the correlation between PAICS expression and the clinical prognosis of gastric cancer patients. TIMER2.0 database and UALCAN database were used to clarify the correlation between the expression of PAICS in gastric cancer tissues and immune cell invasion and related gene markers. Results: The expression level of PAICS was higher than that of normal tissues in a variety of cancers and was statistically significant (P < 0.001), including BLCA (bladder urothelial carcinoma), BRCA (invasive carcinoma of the breast), COAD (colon cancer), ESCA (esophageal cancer), LIHC (hepatocellular carcinoma), LUAD (lung adenocarcinoma), LUSC (lung squamous cell carcinoma), PRAD (prostate cancer), STAD (gastric cancer), THCA (thyroid cancer), UCEC (endometrial cancer). These results suggest that high expression of PAICS is associated with poor prognosis of gastric cancer. PAICS expression was negatively correlated with the infiltration of gastric cancer immune cells (B cells, CD4+T cells, CD8+T cells, neutrophils, macrophages and dendritic cells) (P < 0.01). Conclusion: PAICS significantly affects the prognosis of gastric cancer and can be used as a prognostic biomarker for gastric cancer.
文章引用：于帅, 李启信. PAICS在胃癌中的表达及临床意义[J]. 临床医学进展, 2025, 15(4): 2193-2200. https://doi.org/10.12677/acm.2025.1541170

参考文献

[1] Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. [Google Scholar] [CrossRef] [PubMed]
[2] Joshi, S.S. and Badgwell, B.D. (2021) Current Treatment and Recent Progress in Gastric Cancer. CA: A Cancer Journal for Clinicians, 71, 264-279. [Google Scholar] [CrossRef] [PubMed]
[3] Smyth, E.C., Nilsson, M., Grabsch, H.I., van Grieken, N.C. and Lordick, F. (2020) Gastric Cancer. The Lancet, 396, 635-648. [Google Scholar] [CrossRef] [PubMed]
[4] Li, G.Z., Doherty, G.M. and Wang, J. (2022) Surgical Management of Gastric Cancer. JAMA Surgery, 157, 446-454. [Google Scholar] [CrossRef] [PubMed]
[5] Ajani, J.A. (2005) Evolving Chemotherapy for Advanced Gastric Cancer. The Oncologist, 10, 49-58. [Google Scholar] [CrossRef] [PubMed]
[6] Li, S., Tong, Y., Xie, X., Wang, Q., Zhou, H., Han, Y., et al. (2007) Octameric Structure of the Human Bifunctional Enzyme PAICS in Purine Biosynthesis. Journal of Molecular Biology, 366, 1603-1614. [Google Scholar] [CrossRef] [PubMed]
[7] Zhou, S., Yan, Y., Chen, X., Wang, X., Zeng, S., Qian, L., et al. (2019) Roles of Highly Expressed PAICS in Lung Adenocarcinoma. Gene, 692, 1-8. [Google Scholar] [CrossRef] [PubMed]
[8] Meng, M., Chen, Y., Jia, J., Li, L. and Yang, S. (2018) Knockdown of PAICS Inhibits Malignant Proliferation of Human Breast Cancer Cell Lines. Biological Research, 51, Article No. 24. [Google Scholar] [CrossRef] [PubMed]
[9] Chakravarthi, B.V.S.K., Goswami, M.T., Pathi, S.S., Dodson, M., Chandrashekar, D.S., Agarwal, S., et al. (2018) Expression and Role of PAICS, a de Novo Purine Biosynthetic Gene in Prostate Cancer. The Prostate, 78, 693-694. [Google Scholar] [CrossRef] [PubMed]
[10] Chakravarthi, B.V.S.K., Rodriguez Pena, M.D.C., Agarwal, S., Chandrashekar, D.S., Hodigere Balasubramanya, S.A., Jabboure, F.J., et al. (2018) A Role for de Novo Purine Metabolic Enzyme PAICS in Bladder Cancer Progression. Neoplasia, 20, 894-904. [Google Scholar] [CrossRef] [PubMed]
[11] Goswami, M.T., Chen, G., Chakravarthi, B.V.S.K., Pathi, S.S., Anand, S.K., Carskadon, S.L., et al. (2015) Role and Regulation of Coordinately Expressed de Novo Purine Biosynthetic Enzymes ppat and paics in Lung Cancer. Oncotarget, 6, 23445-23461. [Google Scholar] [CrossRef] [PubMed]
[12] Zaza, G., Yang, W., Kager, L., Cheok, M., Downing, J., Pui, C., et al. (2004) Acute Lymphoblastic Leukemia with TEL-AML1 Fusion Has Lower Expression of Genes Involved in Purine Metabolism and Lower de Novo Purine Synthesis. Blood, 104, 1435-1441. [Google Scholar] [CrossRef] [PubMed]
[13] Wu, X., Gu, Z., Chen, Y., Chen, B., Chen, W., Weng, L., et al. (2019) Application of PD-1 Blockade in Cancer Immunotherapy. Computational and Structural Biotechnology Journal, 17, 661-674. [Google Scholar] [CrossRef] [PubMed]
[14] Shitara, K., Lordick, F., Bang, Y., Enzinger, P., Ilson, D., Shah, M.A., et al. (2023) Zolbetuximab plus mFOLFOX6 in Patients with CLDN18.2-Positive, HER2-Negative, Untreated, Locally Advanced Unresectable or Metastatic Gastric or Gastro-Oesophageal Junction Adenocarcinoma (SPOTLIGHT): A Multicentre, Randomised, Double-Blind, Phase 3 Trial. The Lancet, 401, 1655-1668. [Google Scholar] [CrossRef] [PubMed]
[15] Huang, Q., Liu, F. and Shen, J. (2019) Bioinformatic Validation Identifies Candidate Key Genes in Diffuse Large-B Cell Lymphoma. Personalized Medicine, 16, 313-323. [Google Scholar] [CrossRef] [PubMed]
[16] Tsuchiya, H. and Shiota, G. (2021) Immune Evasion by Cancer Stem Cells. Regenerative Therapy, 17, 20-33. [Google Scholar] [CrossRef] [PubMed]
[17] Li, B., Severson, E., Pignon, J., Zhao, H., Li, T., Novak, J., et al. (2016) Comprehensive Analyses of Tumor Immunity: Implications for Cancer Immunotherapy. Genome Biology, 17, Article No. 174. [Google Scholar] [CrossRef] [PubMed]
[18] Zeng, D., Wu, J., Luo, H., Li, Y., Xiao, J., Peng, J., et al. (2021) Tumor Microenvironment Evaluation Promotes Precise Checkpoint Immunotherapy of Advanced Gastric Cancer. Journal for ImmunoTherapy of Cancer, 9, e002467. [Google Scholar] [CrossRef] [PubMed]

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