GLP-1R基因多态性与妊娠糖尿病相关性研究进展
Research Progress on the Correlation between GLP-1R Gene Polymorphisms and Gestational Diabetes Mellitus
摘要: 近年来，胰高血糖素样肽-1受体(GLP-1R)基因多态性与妊娠糖尿病(GDM)的关联性逐渐成为研究热点。本综述系统梳理了GLP-1R基因多态性(如rs6923761、rs10305420等位点)对GDM发病风险、胰岛素抵抗及糖代谢紊乱的潜在影响，分析了GLP-1R基因多态性与GDM的遗传关联研究，结合表观遗传学及多组学分析，探索基于GLP-1R靶点的个体化干预潜力。此项研究领域进展为GDM的早期预测和精准治疗提供了新视角。
Abstract: In recent years, the correlation between glucagon-like peptide-1 receptor (GLP-1R) gene polymorphisms and gestational diabetes mellitus (GDM) has increasingly become a research focus. This review systematically examines the potential effects of GLP-1R gene polymorphisms (e.g., rs6923761, rs10305420 loci) on GDM risk, insulin resistance, and glucose metabolism disorders. It explores genetic association studies between GLP-1R polymorphisms and GDM, integrates epigenetic and multi-omics analyses, and investigates the potential for individualized interventions targeting GLP-1R. Advances in this field provide novel insights for the early prediction and precision treatment of GDM.
参考文献
|
[1]
|
邵婕, 杨美芳, 张秀. 妊娠期糖尿病患者血清GLP-1及胎盘组织中IGF-1R与新生儿结局的关系[J]. 河北医科大学学报, 2022, 43(9): 1042-1046.
|
|
[2]
|
封伟, 危丽华, 李冬霞, 等. 妊娠13~17周血清GLP-1、Nesfatin-1、PAPP-A与妊娠糖尿病的相关性[J]. 中国性科学, 2022, 31(1): 109-112.
|
|
[3]
|
孙震, 聂小毳. GLP-1R基因rs3765467与rs10305420位点多态性及血脂指标与妊娠糖尿病相关性的前瞻性探讨[J]. 中国优生与遗传杂志, 2021, 29(4): 484-488.
|
|
[4]
|
史琳涛, 李丽君, 程玉霞, 等. 正常体重女性胰岛素早时相分泌受损与妊娠期糖尿病发病关系研究[J]. 中国糖尿病杂志, 2022, 30(6): 416-420.
|
|
[5]
|
蔡素霞, 付泽霞, 宁飞燕. 妊娠期糖尿病患者产后高血糖转归的影响因素及风险预测模型构建[J]. 医药论坛杂志, 2025, 46(4): 365-371.
|
|
[6]
|
高金艳, 翁筱丹, 程佳梨. miR-152和miR-22-3p在妊娠期糖尿病患者外周血中的表达及意义[J]. 中国妇幼保健, 2025, 40(2): 329-333.
|
|
[7]
|
张静, 刘嘉. 妊娠期糖尿病代谢记忆的研究进展[J]. 现代医药卫生, 2025, 41(3): 748-752.
|