狼疮性肾炎复发的相关生物标志物
Biomarkers of Relapses of Lupus Nephritis
DOI: 10.12677/acm.2025.1541192, PDF,   
作者: 韩 雪, 李 秋*:重庆医科大学附属儿童医院肾脏内科,国家儿童健康与疾病临床医学研究中心,儿童发育疾病研究教育部重点实验室,儿童代谢与炎症性疾病重庆市重点实验室,重庆
关键词: 狼疮性肾炎生物标志物复发早期预警Lupus Nephritis Biomarkers Relapse Early Warning
摘要: 狼疮性肾炎(LN)是系统性红斑狼疮(SLE)的常见并发症之一。LN复发是慢性肾脏疾病进展甚至最终达到终末期肾病的重要危险因素,严重影响患者的预后及生存质量。目前传统的临床指标如尿蛋白定量、血清肌酐、尿沉渣、抗dsDNA抗体、抗C1q抗体、补体水平以及肾活检对于提示LN的早期复发不够敏感或特异。因此,长期以来一直寻找能够更好的监测LN疾病活动和识别LN复发的生物标志物。本文总结了与LN复发有关的传统的和新型生物标志物的研究现状以指导LN的临床管理。
Abstract: Lupus Nephritis (LN) is one of the common complications of systemic lupus erythematosus (SLE). LN relapse is an important risk factor for the progression to chronic kidney disease and even end-stage renal disease, which seriously affects the prognosis and quality of life of patients. Currently, traditional clinical markers such as urine protein quantification, serum creatinine, urinary sediment, anti-dsDNA antibody, anti-C1q antibody, complement level, and renal biopsy are not sensitive or specific enough to identify early relapse of LN. Therefore, biomarkers that can better monitor LN disease activity and recognize LN relapse have long been sought. The current status of research on traditional and novel biomarkers associated with LN relapses are summarized in this article to guide the clinical management of LN.
文章引用:韩雪, 李秋. 狼疮性肾炎复发的相关生物标志物[J]. 临床医学进展, 2025, 15(4): 2391-2399. https://doi.org/10.12677/acm.2025.1541192

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