炎症相关指标与心房颤动相关性的研究进展
Research Progress in the Correlation between Inflammation-Related Indicators and Atrial Fibrillation
摘要: 心房颤动(Atrial Fibrillation, AF)是最常见的心律失常之一,表现为心房正常的电活动被快速无序的颤动波取代,具有较高的复发率、致残率及死亡率。近年来,房颤在心血管疾病中占据着重要地位,可导致诸多严重不良后果。随着对房颤机制的深入研究,发现炎症与房颤密切相关。因此本文就相关炎症指标如红细胞分布宽度(Red Blood Cell Distribution Width, RDW)、C反应蛋白(C-Reactive Protein, CRP)、中性粒细胞/淋巴细胞比值(Neutrophil to Lymphocyte Ratio, NLR)、血小板/淋巴细胞比值(Platelet to Lymphocyte Ratio, PLR)等炎症指标与心房颤动相关性的研究进展进行综述。
Abstract: Atrial fibrillation (atrial fibrillation, AF) is one of the most common arrhythmias, and the normal electrical activity of the atrium is replaced by a rapid and disordered fibrillation wave, which has a high rate of recurrence, disability, and mortality. In recent years, AF occupies an important role in cardiovascular diseases and can lead to many serious adverse consequences. With the intensive study of the mechanism of AF, it was found that inflammation is closely related to AF. Therefore, in this paper, the relevant inflammatory indicators, such as red blood cell distribution width (RDW), C-reactive protein (CRP), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and atrial fibrillation were reviewed.
文章引用:兰欣梅. 炎症相关指标与心房颤动相关性的研究进展[J]. 临床医学进展, 2025, 15(4): 2463-2469. https://doi.org/10.12677/acm.2025.1541201

参考文献

[1] 中华医学会心电生理和起搏分会, 中国医师协会心律学专业委员会, 中国房颤中心联盟心房颤动防治专家工作委员会. 心房颤动: 目前的认识和治疗建议(2021) [J]. 中华心律失常学杂志, 2022, 26(1): 15-88.
[2] 周姝冶, 谢美丽, 王智昊. 炎症与心房颤动相关性研究进展[J]. 国际老年医学杂志, 2022, 43(6): 742-746.
[3] 蔡春雨, 余电有, 权里平, 等. 心房颤动发病炎症机制的研究进展[J]. 中国老年学杂志, 2023, 43(3): 751-756.
[4] 赵亚楠, 王贺, 邱承杰, 等. 心房重构、氧化应激在心房颤动发病中作用机制的研究进展[J]. 山东医药, 2018, 58(43): 96-99.
[5] 刘超茜, 邓俊萍. 炎症与心房颤动相关性的研究进展[J]. 中西医结合心脑血管病杂志, 2024, 22(7): 1274-1277.
[6] 李冬菊, 竟雪莹, 汤凤英, 等. 非瓣膜性房颤病人血清CRP、RDW和NLR的变化及其临床意义[J]. 蚌埠医学院学报, 2023, 48(5): 606-609.
[7] Li, X., Peng, S., Wu, X., Guan, B., Tse, G., Chen, S., et al. (2022) C-Reactive Protein and Atrial Fibrillation: Insights from Epidemiological and Mendelian Randomization Studies. Nutrition, Metabolism and Cardiovascular Diseases, 32, 1519-1527. [Google Scholar] [CrossRef] [PubMed]
[8] Jiang, Z., Dai, L., Song, Z., Li, H. and Shu, M. (2013) Association between C‐Reactive Protein and Atrial Fibrillation Recurrence after Catheter Ablation: A Meta‐Analysis. Clinical Cardiology, 36, 548-554. [Google Scholar] [CrossRef] [PubMed]
[9] Meyre, P.B., Sticherling, C., Spies, F., Aeschbacher, S., Blum, S., Voellmin, G., et al. (2020) C-Reactive Protein for Prediction of Atrial Fibrillation Recurrence after Catheter Ablation. BMC Cardiovascular Disorders, 20, Article No. 427. [Google Scholar] [CrossRef] [PubMed]
[10] 赵伟伟, 葛建敏, 王文珊, 等. 血清脑钠肽、高敏C反应蛋白、可溶性生长刺激表达基因2在阵发性心房颤动患者射频消融术后复发中的预测价值[J]. 疑难病杂志, 2023, 22(9): 924-928.
[11] Lin, K., Fan, F., Cai, M., Yu, Y., Fu, C., Ding, L., et al. (2022) Systemic Immune Inflammation Index and System Inflammation Response Index Are Potential Biomarkers of Atrial Fibrillation among the Patients Presenting with Ischemic Stroke. European Journal of Medical Research, 27, Article No. 106. [Google Scholar] [CrossRef] [PubMed]
[12] Galea, R., Cardillo, M.T., Caroli, A., Marini, M.G., Sonnino, C., Narducci, M.L., et al. (2014) Inflammation and C-Reactive Protein in Atrial Fibrillation: Cause or Effect? Texas Heart Institute Journal, 41, 461-468. [Google Scholar] [CrossRef] [PubMed]
[13] Kwon, C.H., Kang, J.G., Lee, H.J., Kim, N.H., Sung, J., Cheong, E., et al. (2016) C-Reactive Protein and Risk of Atrial Fibrillation in East Asians. EP Europace, 19, 1643-1649. [Google Scholar] [CrossRef] [PubMed]
[14] Lee, Y., Park, H., Shin, J., Lim, Y., Shin, J. and Park, J. (2019) Single and Persistent Elevation of C-Reactive Protein Levels and the Risk of Atrial Fibrillation in a General Population: The Ansan-Ansung Cohort of the Korean Genome and Epidemiology Study. International Journal of Cardiology, 277, 240-246. [Google Scholar] [CrossRef] [PubMed]
[15] Tonelli, M., Sacks, F., Arnold, M., Moye, L., Davis, B. and Pfeffer, M. (2008) Relation between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People with Coronary Disease. Circulation, 117, 163-168. [Google Scholar] [CrossRef] [PubMed]
[16] 邵从军. 红细胞分布宽度在临床疾病诊疗中的研究进展[J]. 临床输血与检验, 2021, 23(3): 400-404.
[17] Kurt, M., Tanboga, I.H., Buyukkaya, E., Karakas, M.F., Akçay, A.B. and Sen, N. (2013) Relation of Red Cell Distribution Width with CHA2DS2-VASc Score in Patients with Nonvalvular Atrial Fibrillation. Clinical and Applied Thrombosis/Hemostasis, 20, 687-692. [Google Scholar] [CrossRef] [PubMed]
[18] Li, H., Gu, Y., Liu, M., Wang, X., Chi, V.T.Q., Zhang, Q., et al. (2019) The Relationship between Red Blood Cell Distribution Width and Atrial Fibrillation in Asian Population: A Cross‐Sectional Study. Pacing and Clinical Electrophysiology, 42, 1197-1203. [Google Scholar] [CrossRef] [PubMed]
[19] Jurin, I., Hadžibegović, I., Durlen, I., Jakšić Jurinjak, S., Mišković, D., Ajduk, M., et al. (2019) Left Atrium Size and Red Cell Distribution Width Predict Atrial Fibrillation Progression from Paroxysmal or Persistent to Permanent. Acta Clinica Belgica, 75, 205-211. [Google Scholar] [CrossRef] [PubMed]
[20] Zhou, X., Wang, Z., Dou, S., Chen, K., Liu, E., Liu, T., et al. (2020) Biomarkers for Predicting Left Atrial or Left Atrial Appendage Thrombus in Anticoagulated Patients with Nonvalvular Atrial Fibrillation. Cardiology Research and Practice, 2020, Article ID: 1683142. [Google Scholar] [CrossRef] [PubMed]
[21] Zahorec, R. (2001) Ratio of Neutrophil to Lymphocyte Counts-Rapid and Simple Parameter of Systemic Inflammation and Stress in Critically Ill. Bratislavské Lekárske Listy, 102, 5-14.
[22] Balta, S., Demirkol, S., Unlu, M., Arslan, Z. and Celik, T. (2013) Neutrophil to Lymphocyte Ratio May Be Predict of Mortality in All Conditions. British Journal of Cancer, 109, 3125-3126. [Google Scholar] [CrossRef] [PubMed]
[23] Harada, M., Van Wagoner, D.R. and Nattel, S. (2015) Role of Inflammation in Atrial Fibrillation Pathophysiology and Management. Circulation Journal, 79, 495-502. [Google Scholar] [CrossRef] [PubMed]
[24] Shao, Q., Chen, K., Rha, S., Lim, H., Li, G. and Liu, T. (2015) Usefulness of Neutrophil/Lymphocyte Ratio as a Predictor of Atrial Fibrillation: A Meta-Analysis. Archives of Medical Research, 46, 199-206. [Google Scholar] [CrossRef] [PubMed]
[25] Berkovitch, A., Younis, A., Grossman, Y., Segev, S., Kivity, S., Sidi, Y., et al. (2019) Relation of Neutrophil to Lymphocyte Ratio to Risk of Incident Atrial Fibrillation. The American Journal of Cardiology, 123, 396-401. [Google Scholar] [CrossRef] [PubMed]
[26] Shao, Q.M., Xu, G., Miao, S., et al. (2014) Increased Neutrophil/Lymphocyte Ratio and Red Blood Cell Distribution Width Levels in Patients with Non-Valvular Atrial Fibrillation. Experimental & Clinical Cardiology, 20, 2827-2842.
[27] Karavelioğlu, Y., Karapınar, H., Yüksel, M., Memiç, K., Sarak, T., Kurt, R., et al. (2014) Neutrophil to Lymphocyte Ratio Is Predictor of Atrial Fibrillation Recurrence after Cardioversion with Amiodarone. Clinical and Applied Thrombosis/Hemostasis, 21, 5-9. [Google Scholar] [CrossRef] [PubMed]
[28] Lu, M., Zhang, Y., Liu, R., He, X. and Hou, B. (2022) Predictive Value of Neutrophil to Lymphocyte Ratio for Ischemic Stroke in Patients with Atrial Fibrillation: A Meta-Analysis. Frontiers in Neurology, 13, Article ID: 1029010. [Google Scholar] [CrossRef] [PubMed]
[29] Güngör, B., Özcan, K.S., Erdinler, İ., Ekmekçi, A., Alper, A.T., Osmonov, D., et al. (2013) Elevated Levels of RDW Is Associated with Non-Valvular Atrial Fibrillation. Journal of Thrombosis and Thrombolysis, 37, 404-410. [Google Scholar] [CrossRef] [PubMed]
[30] 陈怡卉, 龚燕锋. 血小板/淋巴细胞比值与心血管系统疾病的相关研究进展[J]. 实用老年医学, 2023, 37(9): 956-959+972.
[31] Marx, C., Novotny, J., Salbeck, D., Zellner, K.R., Nicolai, L., Pekayvaz, K., et al. (2019) Eosinophil-Platelet Interactions Promote Atherosclerosis and Stabilize Thrombosis with Eosinophil Extracellular Traps. Blood, 134, 1859-1872. [Google Scholar] [CrossRef] [PubMed]
[32] Kim, S., Eliot, M., Koestler, D.C., Wu, W. and Kelsey, K.T. (2018) Association of Neutrophil-to-Lymphocyte Ratio with Mortality and Cardiovascular Disease in the Jackson Heart Study and Modification by the Duffy Antigen Variant. JAMA Cardiology, 3, 455-462. [Google Scholar] [CrossRef] [PubMed]
[33] Procter, N.E., Ball, J., Ngo, D.T., et al. (2016) Gender and Tachycardia: Independent Modulation of Platelet Reactivity in Patients with Atrial Fibrillation. Journal of Geriatric Cardiology: JGC, 13, 202-208.
[34] Gary, T., Pichler, M., Belaj, K., Hafner, F., Gerger, A., Froehlich, H., et al. (2013) Platelet-to-Lymphocyte Ratio: A Novel Marker for Critical Limb Ischemia in Peripheral Arterial Occlusive Disease Patients. PLOS ONE, 8, e67688. [Google Scholar] [CrossRef] [PubMed]
[35] Gungor, H., Babu, A.S., Zencir, C., Akpek, M., Selvi, M., Erkan, M.H., et al. (2016) Association of Preoperative Platelet-to-Lymphocyte Ratio with Atrial Fibrillation after Coronary Artery Bypass Graft Surgery. Medical Principles and Practice, 26, 164-168. [Google Scholar] [CrossRef] [PubMed]
[36] Altintas, O., Tasal, A., Niftaliyev, E., Kucukdagli, O.T. and Asil, T. (2016) Association of Platelet-to-Lymphocyte Ratio with Silent Brain Infarcts in Patients with Paroxysmal Atrial Fibrillation. Neurological Research, 38, 753-758. [Google Scholar] [CrossRef] [PubMed]
[37] Jin, Z., Wu, Q., Chen, S., Gao, J., Li, X., Zhang, X., et al. (2021) The Associations of Two Novel Inflammation Indexes, SII and SIRI with the Risks for Cardiovascular Diseases and All-Cause Mortality: A Ten-Year Follow-Up Study in 85,154 Individuals. Journal of Inflammation Research, 14, 131-140. [Google Scholar] [CrossRef] [PubMed]
[38] Hu, B., Yang, X., Xu, Y., Sun, Y., Sun, C., Guo, W., et al. (2014) Systemic Immune-Inflammation Index Predicts Prognosis of Patients after Curative Resection for Hepatocellular Carcinoma. Clinical Cancer Research, 20, 6212-6222. [Google Scholar] [CrossRef] [PubMed]
[39] Bağcı, A. and Aksoy, F. (2021) Systemic Immune-Inflammation Index Predicts New-Onset Atrial Fibrillation after ST Elevation Myocardial Infarction. Biomarkers in Medicine, 15, 731-739. [Google Scholar] [CrossRef] [PubMed]
[40] Hinoue, T., Yatabe, T. and Nishida, O. (2022) Prediction of Postoperative Atrial Fibrillation with the Systemic Immune-Inflammation Index in Patients Undergoing Cardiac Surgery Using Cardiopulmonary Bypass: A Retrospective, Single-Center Study. Journal of Artificial Organs, 26, 112-118. [Google Scholar] [CrossRef] [PubMed]
[41] Luo, Y., Zhang, J., Liu, T., Yin, Z., Jin, Y., Han, J., et al. (2022) The Systemic-Immune-Inflammation Index Predicts the Recurrence of Atrial Fibrillation after Cryomaze Concomitant with Mitral Valve Surgery. BMC Cardiovascular Disorders, 22, Article No. 45. [Google Scholar] [CrossRef] [PubMed]
[42] 王 越, 郑汝杰, 袁明月, 等. 系统性免疫炎症指数对老年心房颤动患者预后价值的研究[J]. 中华老年心脑血管病杂志, 2022, 24(2): 136-139.
[43] 吴照科, 白莹, 阿曼古力·瓦衣提, 等. 全身免疫炎症指数对非瓣膜性房颤患者缺血性脑卒中的预测价值[J]. 中国实用神经疾病杂, 2023, 26(4): 453-459.
[44] Qi, Q., Zhuang, L., Shen, Y., Geng, Y., Yu, S., Chen, H., et al. (2016) A Novel Systemic Inflammation Response Index (SIRI) for Predicting the Survival of Patients with Pancreatic Cancer after Chemotherapy. Cancer, 122, 2158-2167. [Google Scholar] [CrossRef] [PubMed]
[45] Chi, R., Shan, X., Guan, C., Yang, H., Wang, X., Li, B., et al. (2023) Association between Systemic Inflammatory Response Index and Left Ventricular Remodeling and Systolic Dysfunction in Atrial Fibrillation Patients. BMC Cardiovascular Disorders, 23, Article No. 377. [Google Scholar] [CrossRef] [PubMed]
[46] Wu, Y., Meng, Y., Yi, W., Pan, R., Liang, Y., Li, Y., et al. (2023) The Ratio of Monocyte Count and High-Density Lipoprotein Cholesterol Mediates the Association between Urinary Tungsten and Cardiovascular Disease: A Study from NHANES 2005-2018. Environmental Science and Pollution Research, 30, 85930-85939. [Google Scholar] [CrossRef] [PubMed]
[47] Tekkesin, A.I., Hayiroglu, M.I., Zehir, R., et al. (2017) The Use of Monocyte to HDL Ratio to Predict Postoperative Atrial Fibrillation after Aortocoronary Bypass Graft Surgery. Northern Clinics of İstanbul, 4, 145-150.
[48] Adili, A., Wang, Y., Zhu, X., Cao, H., Fan, F., Tang, X., et al. (2020) Preoperative Monocyte‐to‐HDL‐Cholesterol Ratio Predicts Early Recurrence after Radiofrequency Maze Procedure of Valvular Atrial Fibrillation. Journal of Clinical Laboratory Analysis, 35, e23595. [Google Scholar] [CrossRef] [PubMed]