MAPK信号通路在绝经后骨质疏松症骨重建失衡中的作用及干预研究进展
Research Progress on the Role and Intervention of the MAPK Signaling Pathway in the Imbalance of Bone Remodeling in Postmenopausal Osteoporosis
DOI: 10.12677/acm.2025.1541204, PDF,   
作者: 颜雍霖*, 孙承霞, 黄明雄, 王孝杰：成都中医药大学临床医学院，四川 成都；高永翔#：成都中医药大学附属医院风湿免疫科，四川 成都
关键词: MAPK信号通路；骨重建；绝经后骨质疏松症；作用机理；MAPK Signaling Pathway； Bone Remodeling； Postmenopausal Osteoporosis； Mechanism of Action
摘要: 绝经后骨质疏松症(PMOP)是一种与雌激素缺乏密切相关的代谢性骨病，其核心特征为骨重建失衡。丝裂原活化蛋白激酶(MAPK)信号通路在这一过程中发挥着关键作用。本文系统阐述了MAPK信号通路的组成、激活机制，及其在PMOP骨重建失衡中的作用。MAPK信号通路包含ERK、JNK、p38MAPK和ERK5等分支，雌激素缺乏及细胞因子网络失衡可激活该通路。在PMOP中，MAPK信号通路对成骨细胞的增殖、分化、矿化以及骨髓间充质干细胞的成脂分化产生不同影响，同时也调节破骨细胞的分化、活化和骨吸收功能，并与OPG/RANKL/RANK系统相互作用。此外，本文还对现有干预策略进行了评估，指出当前研究的局限性，并提出基于多组学技术的精准治疗是未来的发展方向，旨在为开发高效低毒的PMOP治疗方案提供理论依据。
Abstract: Postmenopausal osteoporosis (PMOP) is a metabolic bone disease closely related to estrogen deficiency, and its core feature is the imbalance of bone remodeling. The mitogen-activated protein kinase (MAPK) signaling pathway plays a crucial role in this process. This article systematically expounds on the composition and activation mechanism of the MAPK signaling pathway, as well as its role in the imbalance of bone remodeling in PMOP. The MAPK signaling pathway includes branches such as ERK, JNK, p38MAPK, and ERK5. Estrogen deficiency and the imbalance of the cytokine network can activate this pathway. In PMOP, the MAPK signaling pathway has different effects on the proliferation, differentiation, and mineralization of osteoblasts, as well as the adipogenic differentiation of bone marrow mesenchymal stem cells. It also regulates the differentiation, activation, and bone resorption function of osteoclasts and interacts with the OPG/RANKL/RANK system. In addition, this article evaluates the existing intervention strategies, points out the limitations of current research, and proposes that precision medicine based on multi-omics technology is the future development direction, aiming to provide a theoretical basis for the development of highly effective and low-toxicity treatment regimens for PMOP.
文章引用：颜雍霖, 孙承霞, 黄明雄, 王孝杰, 高永翔. MAPK信号通路在绝经后骨质疏松症骨重建失衡中的作用及干预研究进展[J]. 临床医学进展, 2025, 15(4): 2483-2493. https://doi.org/10.12677/acm.2025.1541204

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