子宫颈透明细胞癌合并双侧卵巢透明细胞癌1例

A Case of Cervical Clear Cell Carcinoma Concurrent with Bilateral Ovarian Clear Cell Carcinoma

摘要: 目的：探讨子宫颈透明细胞癌(Clear cell cervical adenocarcinoma, CCAC)的临床特征，提高临床医师对该病的认识。特别是对于年轻患者，应警惕其高度侵袭性，重视早期诊断和综合治疗，以改善患者预后。方法：本文报道山东大学齐鲁医院收治的1例21岁特发性子宫颈透明细胞癌合并双侧卵巢透明细胞癌患者，分析其临床表现、影像学及病理学特征、诊断及治疗经过，并结合既往文献进行回顾与总结。结论：CCAC是一种罕见且高度侵袭性的子宫颈腺癌，在年轻女性中较少见，且与人乳头瘤病毒(HPV)感染无明显相关性。临床上对于不明原因的异常阴道流血、子宫颈肿物或盆腔包块的年轻患者，应提高警惕，尽早行影像学及病理学检查，以实现早发现、早诊断、早治疗。此外，未来仍需进一步探索CCAC的分子机制及最佳治疗策略，以优化个体化治疗方案，提高患者长期生存率。

Abstract: Objective: To investigate the clinical characteristics of clear cell carcinoma of the cervix and enhance clinicians’ awareness of this disease. Particular attention should be given to its highly aggressive nature in young patients, emphasizing the importance of early diagnosis and comprehensive treatment to improve prognosis. Methods: This study reports a case of a 21-year-old patient diagnosed with idiopathic CCAC concurrent with bilateral ovarian clear cell carcinoma, treated at Qilu Hospital of Shandong University. The patient’s clinical presentation, imaging and pathological characteristics, diagnostic process, and treatment course were analyzed. A review of relevant literature was also conducted for further discussion. Conclusion: CCAC is a rare and highly aggressive subtype of cervical adenocarcinoma, with low prevalence in young women and no significant correlation with human papillomavirus infection. Clinicians should remain vigilant when encountering young patients presenting with unexplained abnormal uterine bleeding, cervical masses, or pelvic tumors, and should promptly conduct imaging and pathological evaluations to facilitate early detection, accurate diagnosis, and timely intervention. Furthermore, future research should focus on elucidating the molecular mechanisms underlying CCAC and optimizing therapeutic strategies to improve individualized treatment plans and enhance long-term survival outcomes.