压电生物材料与生物电用于骨组织工程
Piezoelectric Biomaterials and Bioelectricity for Bone Tissue Engineering
DOI: 10.12677/ms.2025.154079, PDF,   
作者: 杨 聪*, 张晓南#：重庆医科大学附属口腔医院，重庆；口腔疾病与生物医学重庆市重点实验室，重庆；重庆市高校市级口腔生物医学工程重点实验室，重庆
关键词: 压电生物材料；生物电；骨组织工程；机制；Piezoelectric Biomaterials； Bioelectricity； Bone Tissue Engineering； Mechanism
摘要: 生物支架模拟组织/细胞微环境在骨组织工程中具有巨大的潜力。近年来，压电生物电活性生物材料不仅能够满足作为细胞粘附和结构支撑的支架，而且能够调节细胞/组织行为和功能，特别是产生生物电辅助细胞和组织再生的机制层面，在近些年来越来越受到关注。更重要的是，生物电刺激可以调节许多的生物过程，从细胞周期、迁移、增殖和分化到神经传导、肌肉收缩、胚胎发生和组织再生。本文介绍了骨形成和修复的过程。然后，讨论了生物电在促进骨修复方面具有积极的促进作用，压电生物材料介导的电刺激和应用途径。系统综述了压电生物材料在调节成骨和破骨细胞命运从而促进骨组织再生方面的相关前沿研究和进展。最后展望了压电生物活性材料的未来前景。
Abstract: Bioscaffolds have great potential in bone tissue engineering to simulate tissue/cell microenvironment. In recent years, piezoelectric bioelectroactive biomaterials not only can be used as scaffolds for cell adhesion and structural support, but also can regulate cell/tissue behavior and function, especially in the mechanism of generating bioelectricity to assist cell and tissue regeneration, which has attracted more and more attention in recent years. More importantly, bioelectrical stimulation can regulate many biological processes, from cell cycle, migration, proliferation, and differentiation to nerve conduction, muscle contraction, embryogenesis, and tissue regeneration. This article describes the process of bone formation and repair. Then, the active role of bioelectricity in promoting bone repair, the electrical stimulation mediated by piezoelectric biomaterial and the application ways are discussed. This paper reviews the research progress of piezoelectric biomaterials in regulating the fate of osteoblast and osteoclast to promote bone regeneration. In addition, future investigation work on the piezoelectric bioactive materials is also envisioned.
文章引用：杨聪, 张晓南. 压电生物材料与生物电用于骨组织工程[J]. 材料科学, 2025, 15(4): 742-751. https://doi.org/10.12677/ms.2025.154079

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