手性金属纳米团簇对映体拆分技术及应用的研究进展

Research Progress on the Resolution Technology and Application of Chiral Metal Nanocluster Enantiomers

摘要: 手性金属纳米团簇作为一类特殊的纳米材料，近年来在手性催化、生物医学、光学材料以及信息存储等方面展现出巨大的应用潜力。本文从引言入手，介绍了手性金属纳米团簇的研究背景和发展历程，阐述了其在不对称催化、生物医学、光学材料等领域的广泛应用前景。在手性来源探究部分，详细分析了手性金属内核、团簇表面配体不对称排列以及手性配体这三种手性来源，并通过具体案例和研究成果来支撑这些观点。接着，文章深入探讨了手性金属纳米团簇的对映体拆分技术，包括超分子组装策略、结晶自组装、手性离子对策略、高效手性液相色谱法、手性配体拆分以及手性诱导剂拆分等方法，每种技术都有相应的研究实例和成果展示。在应用部分，重点阐述了手性金属纳米团簇在不对称催化和光学器件构建方面的应用，通过具体的研究成果展示了其在这些领域的潜力。最后，在总结与展望部分，对目前的研究成果进行了总结，并指出了未来研究的方向和面临的挑战，如提高光学活性、实现大规模制备以及拓展应用领域等。

Abstract: Chiral metal nanoclusters, as a special type of nanomaterials, have demonstrated great potential in various fields such as chiral catalysis, biomedicine, optical materials, and information storage in recent years. This article begins with the introduction, presenting the research background and development history of chiral metal nanoclusters, and elaborating on their extensive application prospects in asymmetric catalysis, biomedicine, optical materials, etc. In the section on the exploration of chiral sources, the three sources of chirality—chiral metal cores, asymmetric arrangement of surface ligands on nanoclusters, and chiral ligands—are analyzed in detail, supported by specific cases and research results. Subsequently, the article delves into the resolution techniques of chiral metal nanoclusters, including supramolecular assembly strategies, crystalline self-assembly, chiral ion pair strategies, efficient chiral liquid chromatography, chiral ligand resolution, and chiral inducer resolution, each with corresponding research examples and achievements. In the application section, it focuses on the applications of chiral metal nanoclusters in asymmetric catalysis and the construction of optical devices, demonstrating their potential through specific research results. Finally, in the summary and outlook section, the current research achievements are summarized, and the future research directions and challenges are pointed out, such as improving optical activity, achieving large-scale production, and expanding application fields.