有氧运动对原发性开角型青光眼患者眼内压的短期影响：一项Meta分析
Aerobic Exercise Has a Limited Short Time Effect on Reducing IOP in POAG Patients: A Meta-Analysis
摘要: 背景：多项研究表明，有氧运动可以降低正常人眼内压(Intraocular Pressure, IOP)，但是原发性开角型青光眼(POAG)患者是否需要有氧运动来降低眼内压(IOP)仍存在争议。目标：探讨有氧运动是否能降低POAG患者眼内压。方法：纳入分析的研究来自以下数据库：Embase数据库、PubMed、Web of Science、Cochrane图书馆、中国知网(CNKI)，这些研究均在2023年9月前发表且不受语言限制。本Meta分析使用R 4.1.2 (R；GitHub，旧金山，美国)进行，根据Q检验结果计算平均值和标准差(SD)。为评估结果的稳定性，本研究进行了敏感性分析，并通过漏斗图检验发表偏倚。采用纽卡斯尔–渥太华量表(NOS)和Cochrane干预措施系统评价手册来评估每项研究的偏倚风险。结果：本荟萃分析共纳入5项队列研究和1项随机对照RCT (Randomized Controlled Trial)研究，共338只眼。汇总数据显示，这些研究的异质性较高(I2 = 97, P < 0.01)。随机效应模型显示，有氧运动有降低POAG患者眼内压的趋势，但未达到显著水平(SMD = 0.84, 95%CI [−1.14, 2.82])。结论：我们的研究显示，有氧运动可能对POAG患者在短时间内降低IOP的影响有限。然而，我们发现的机制仍需进一步研究。
Abstract: Background: Multiple studies have shown that aerobic exercise could reduce the intraocular pressure of normal people. However, whether patients with primary open-angle glaucoma (POAG) need aerobic exercise to decrease their intraocular pressure (IOP) is still controversial. Objective: To investigate whether aerobic exercise could reduce the intraocular pressure of patients with POAG. Methods: Studies included in this meta-analysis are from the following databases: Embase database, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), which were published before September 2021 without any language restrictions. This meta-analysis was performed by R 4.1.2 (R; GitHub, San Francisco, US), and the means and standard deviation (SD) were calculated based on the results of the Q-test. A sensitivity analysis was performed to determine the stability of the results, and publication bias was evaluated by a funnel plot. The Newcastle-Ottawa Scale (NOS) and Cochrane Handbook for Systematic Reviews of Interventions were used to assess the risk of bias of each study. Results: A total of 5 cohort studies and 1 RCT, 338 eyes, were included in this meta-analysis. The pooled data indicated that the high heterogeneity among these studies (I2 = 97, P < 0.01). The random effect model showed that aerobic exercise had a tendency to reduce intraocular pressure in POAG patients, but did not reach a significant level (SMD = 0.84, 95%CI [−1.14, 2.82]). Conclusion: Our study reveals that aerobic exercise may have a limited effect on decreasing IOP in patients with POAG in a short time. However, the mechanisms of our findings still need further investigation.
文章引用：安新哲, 徐小凡, 陈智豪, 蓝卫忠. 有氧运动对原发性开角型青光眼患者眼内压的短期影响：一项Meta分析[J]. 临床医学进展, 2025, 15(4): 3001-3009. https://doi.org/10.12677/acm.2025.1541265

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