基于神经内分泌调节探讨针灸治疗神经障碍的潜在机制
Exploration of the Potential Mechanisms of Acupuncture in Treating Neurological Disorders Based on Neuroendocrine Regulation
DOI: 10.12677/tcm.2025.144242, PDF,   
作者: 朴恩燃:天津中医药大学研究生院,天津;郑国斌:天津医科大学朱宪彝纪念医院内分泌科,天津市内分泌研究所,国家卫健委激素与发育重点实验室,天津市代谢性疾病重点实验室,天津;吉学群*:天津市中医药研究院附属医院针灸一科,天津
关键词: 针灸精神障碍神经内分泌调节Acupuncture Mental Disorder Neuroendocrine Modulation
摘要: 针灸作为中医的基石,在西方医学中因其通过神经内分泌调节治疗精神障碍的潜力而得到认可。本综述探讨了神经内分泌系统在调节情绪、压力和心理健康方面的作用,重点研究了下丘脑–垂体–肾上腺轴、下丘脑–垂体–甲状腺轴、下丘脑–垂体–性腺轴、神经递质(血清素、多巴胺、γ-氨基丁酸)和皮质醇等关键组成部分。讨论了针灸对这些元素的影响,强调了其对神经内分泌轴和神经递质系统的双向调节作用。证据表明,针灸在治疗焦虑、抑郁、失眠和创伤后应激障碍方面具有疗效,展示了其作为心理健康护理辅助疗法的潜力。尽管需要进一步的高质量研究,但当前的证据支持针灸在治疗精神障碍中的作用。本综述强调了针灸通过神经内分泌调节的治疗潜力,并倡导继续研究和临床应用,以扩大精神障碍的治疗选择。
Abstract: Acupuncture, a cornerstone of Traditional Chinese Medicine, has gained recognition in Western medicine for its potential to treat mental disorders through neuroendocrine modulation. This review explores the neuroendocrine system’s role in regulating mood, stress, and mental health, focusing on key components such as the hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-thyroid axis, hypothalamic-pituitary-gonadal axis, neurotransmitters (serotonin, dopamine, gamma-aminobutyric acid), and cortisol. The effects of acupuncture on these elements are discussed, highlighting its bidirectional modulation of neuroendocrine axes and neurotransmitter systems. Evidence suggests acupuncture’s efficacy in treating anxiety, depression, insomnia, and post-traumatic stress disorder, demonstrating its potential as an adjunctive therapy for mental health care. While further high-quality research is necessary, current evidence supports acupuncture’s role in mental disorders treatment. This review underscores acupuncture’s therapeutic potential through neuroendocrine regulation and advocates for continued research and clinical application to expand treatment options for mental disorders.
文章引用:朴恩燃, 郑国斌, 吉学群. 基于神经内分泌调节探讨针灸治疗神经障碍的潜在机制[J]. 中医学, 2025, 14(4): 1614-1623. https://doi.org/10.12677/tcm.2025.144242

参考文献

[1] Zhu, J., Li, J., Yang, L. and Liu, S. (2021) Acupuncture, from the Ancient to the Current. The Anatomical Record, 304, 2365-2371. [Google Scholar] [CrossRef] [PubMed]
[2] Sowa-Kućma, M. and Stachowicz, K. (2023) Molecular Research on Mental Disorders. International Journal of Molecular Sciences, 24, Article 7104. [Google Scholar] [CrossRef] [PubMed]
[3] Yu, J., Zeng, B. and Hsieh, C. (2013) Acupuncture Stimulation and Neuroendocrine Regulation. International Review of Neurobiology, 111, 125-140. [Google Scholar] [CrossRef] [PubMed]
[4] Kaptchuk, T.J. (2002) Acupuncture: Theory, Efficacy, and Practice. Annals of Internal Medicine, 136, 374-383. [Google Scholar] [CrossRef] [PubMed]
[5] Zhang, Y., Chen, Q., Wang, Q., Ding, S., Li, S., Chen, S., et al. (2020) Role of Parameter Setting in Electroacupuncture: Current Scenario and Future Prospects. Chinese Journal of Integrative Medicine, 28, 953-960. [Google Scholar] [CrossRef] [PubMed]
[6] Soliman, N. and Frank, B.L. (1999) Auricular Acupuncture and Auricular Medicine. Physical Medicine and Rehabilitation Clinics of North America, 10, 547-554.
[7] Smith, C., Reddy, B., Wolf, C., Schnyer, R., St John, K., Conboy, L., et al. (2024) The State of 21st Century Acupuncture in the United States. Journal of Pain Research, 17, 3329-3354. [Google Scholar] [CrossRef] [PubMed]
[8] Zheng, J., Zhu, J., Wang, Y. and Tian, Z. (2024) Effects of Acupuncture on Hypothalamic-Pituitary-Adrenal Axis: Current Status and Future Perspectives. Journal of Integrative Medicine, 22, 445-458. [Google Scholar] [CrossRef] [PubMed]
[9] Chen, T., Zhang, W.W., Chu, Y. and Wang, Y. (2020) Acupuncture for Pain Management: Molecular Mechanisms of Action. The American Journal of Chinese Medicine, 48, 793-811. [Google Scholar] [CrossRef] [PubMed]
[10] Yang, N., Lin, L., Li, Y., Li, H., Cao, Y., Tan, C., et al. (2022) Potential Mechanisms and Clinical Effectiveness of Acupuncture in Depression. Current Neuropharmacology, 20, 738-750. [Google Scholar] [CrossRef] [PubMed]
[11] Amorim, D., Amado, J., Brito, I., Fiuza, S.M., Amorim, N., Costeira, C., et al. (2018) Acupuncture and Electroacupuncture for Anxiety Disorders: A Systematic Review of the Clinical Research. Complementary Therapies in Clinical Practice, 31, 31-37. [Google Scholar] [CrossRef] [PubMed]
[12] Liao, H., Satyanarayanan, S.K., Lin, Y. and Su, K. (2023) Clinical Efficacy and Immune Effects of Acupuncture in Patients with Comorbid Chronic Pain and Major Depression Disorder: A Double-Blinded, Randomized Controlled Crossover Study. Brain, Behavior, and Immunity, 110, 339-347. [Google Scholar] [CrossRef] [PubMed]
[13] Yang, X., Yang, N., Huang, F., Ren, S. and Li, Z. (2021) Effectiveness of Acupuncture on Anxiety Disorder: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Annals of General Psychiatry, 20, Article No. 9. [Google Scholar] [CrossRef] [PubMed]
[14] Hollifield, M., Hsiao, A., Smith, T., Calloway, T., Jovanovic, T., Smith, B., et al. (2024) Acupuncture for Combat-Related Posttraumatic Stress Disorder: A Randomized Clinical Trial. JAMA Psychiatry, 81, 545-554. [Google Scholar] [CrossRef] [PubMed]
[15] Yin, X., Gou, M., Xu, J., Dong, B., Yin, P., Masquelin, F., et al. (2017) Efficacy and Safety of Acupuncture Treatment on Primary Insomnia: A Randomized Controlled Trial. Sleep Medicine, 37, 193-200. [Google Scholar] [CrossRef] [PubMed]
[16] Zacharjasz, J., Sztachera, M., Smuszkiewicz, M. and Piwecka, M. (2024) Micromanaging the Neuroendocrine System—A Review on MIR‐7 and the Other Physiologically Relevant miRNAs in the Hypothalamic-Pituitary Axis. FEBS Letters, 598, 1557-1575. [Google Scholar] [CrossRef] [PubMed]
[17] Altemus, M. (2019) Neuroendocrine Networks and Functionality. Medical Clinics of North America, 103, 601-612. [Google Scholar] [CrossRef] [PubMed]
[18] Toni, R., Malaguti, A., Castorina, S., Roti, E. and Lechan, R.M. (2004) New Paradigms in Neuroendocrinology: Relationships between Obesity, Systemic Inflammation and the Neuroendocrine System. Journal of Endocrinological Investigation, 27, 182-186. [Google Scholar] [CrossRef] [PubMed]
[19] Joseph, D. and Whirledge, S. (2017) Stress and the HPA Axis: Balancing Homeostasis and Fertility. International Journal of Molecular Sciences, 18, Article 2224. [Google Scholar] [CrossRef] [PubMed]
[20] Knezevic, E., Nenic, K., Milanovic, V. and Knezevic, N.N. (2023) The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders. Cells, 12, Article 2726. [Google Scholar] [CrossRef] [PubMed]
[21] Cheiran Pereira, G., Piton, E., Moreira dos Santos, B., Ramanzini, L.G., Muniz Camargo, L.F., Menezes da Silva, R., et al. (2021) Microglia and HPA Axis in Depression: An Overview of Participation and Relationship. The World Journal of Biological Psychiatry, 23, 165-182. [Google Scholar] [CrossRef] [PubMed]
[22] Daskalakis, N.P., Cohen, H., Nievergelt, C.M., Baker, D.G., Buxbaum, J.D., Russo, S.J., et al. (2016) New Translational Perspectives for Blood-Based Biomarkers of PTSD: From Glucocorticoid to Immune Mediators of Stress Susceptibility. Experimental Neurology, 284, 133-140. [Google Scholar] [CrossRef] [PubMed]
[23] Reeves, J.W., Fisher, A.J., Newman, M.G. and Granger, D.A. (2016) Sympathetic and Hypothalamic‐Pituitary‐Adrenal Asymmetry in Generalized Anxiety Disorder. Psychophysiology, 53, 951-957. [Google Scholar] [CrossRef] [PubMed]
[24] Misiak, B., Łoniewski, I., Marlicz, W., Frydecka, D., Szulc, A., Rudzki, L., et al. (2020) The HPA Axis Dysregulation in Severe Mental Illness: Can We Shift the Blame to Gut Microbiota? Progress in Neuro-Psychopharmacology and Biological Psychiatry, 102, Article ID: 109951. [Google Scholar] [CrossRef] [PubMed]
[25] Ortiga‐Carvalho, T.M., Chiamolera, M.I., Pazos‐Moura, C.C. and Wondisford, F.E. (2016) Hypothalamus‐Pituitary‐Thyroid Axis. Comprehensive Physiology, 6, 1387-1428. [Google Scholar] [CrossRef
[26] Zhou, H., Zhu, H., Wang, J., Gao, X. and Jiang, C. (2024) Association between Hypothyroidism Subtypes and Major Depression: A Two-Sample Mendelian Randomization Study. Journal of Affective Disorders, 351, 843-852. [Google Scholar] [CrossRef] [PubMed]
[27] Chen, G., Lv, H., Zhang, X., Gao, Y., Liu, X., Gu, C., et al. (2022) Assessment of the Relationships between Genetic Determinants of Thyroid Functions and Bipolar Disorder: A Mendelian Randomization Study. Journal of Affective Disorders, 298, 373-380. [Google Scholar] [CrossRef] [PubMed]
[28] Kaprara, A. and Huhtaniemi, I.T. (2018) The Hypothalamus-Pituitary-Gonad Axis: Tales of Mice and Men. Metabolism, 86, 3-17. [Google Scholar] [CrossRef] [PubMed]
[29] Hwang, W.J., Lee, T.Y., Kim, N.S. and Kwon, J.S. (2020) The Role of Estrogen Receptors and Their Signaling across Psychiatric Disorders. International Journal of Molecular Sciences, 22, Article 373. [Google Scholar] [CrossRef] [PubMed]
[30] Riecher-Rössler, A. (2017) Oestrogens, Prolactin, Hypothalamic-Pituitary-Gonadal Axis, and Schizophrenic Psychoses. The Lancet Psychiatry, 4, 63-72. [Google Scholar] [CrossRef] [PubMed]
[31] Oyola, M.G. and Handa, R.J. (2017) Hypothalamic-Pituitary-Adrenal and Hypothalamic-Pituitary-Gonadal Axes: Sex Differences in Regulation of Stress Responsivity. Stress, 20, 476-494. [Google Scholar] [CrossRef] [PubMed]
[32] Swaab, D.F., Bao, A. and Lucassen, P.J. (2005) The Stress System in the Human Brain in Depression and Neurodegeneration. Ageing Research Reviews, 4, 141-194. [Google Scholar] [CrossRef] [PubMed]
[33] Dardente, H. and Simonneaux, V. (2022) GnRH and the Photoperiodic Control of Seasonal Reproduction: Delegating the Task to Kisspeptin and RFRP‐3. Journal of Neuroendocrinology, 34, e13124. [Google Scholar] [CrossRef] [PubMed]
[34] Xie, Q., Kang, Y., Zhang, C., Xie, Y., Wang, C., Liu, J., et al. (2022) The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction. Frontiers in Endocrinology, 13, Article 925206. [Google Scholar] [CrossRef] [PubMed]
[35] Tsigos, C. and Chrousos, G.P. (2002) Hypothalamic-Pituitary-Adrenal Axis, Neuroendocrine Factors and Stress. Journal of Psychosomatic Research, 53, 865-871. [Google Scholar] [CrossRef] [PubMed]
[36] Neumann, A., Schmidt, C.X., Brockmann, R.M. and Oster, H. (2019) Circadian Regulation of Endocrine Systems. Autonomic Neuroscience, 216, 1-8. [Google Scholar] [CrossRef] [PubMed]
[37] Góralczyk-Bińkowska, A., Szmajda-Krygier, D. and Kozłowska, E. (2022) The Microbiota-Gut-Brain Axis in Psychiatric Disorders. International Journal of Molecular Sciences, 23, Article 11245. [Google Scholar] [CrossRef] [PubMed]
[38] Generoso, J.S., Giridharan, V.V., Lee, J., Macedo, D. and Barichello, T. (2021) The Role of the Microbiota-Gut-Brain Axis in Neuropsychiatric Disorders. Brazilian Journal of Psychiatry, 43, 293-305. [Google Scholar] [CrossRef] [PubMed]
[39] Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., et al. (2021) The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders. Pharmacological Research, 172, Article ID: 105840. [Google Scholar] [CrossRef] [PubMed]
[40] Hu, J., Abdullah, A., Nanna, M.G. and Soufer, R. (2023) The Brain-Heart Axis: Neuroinflammatory Interactions in Cardiovascular Disease. Current Cardiology Reports, 25, 1745-1758. [Google Scholar] [CrossRef] [PubMed]
[41] Doehner, W., Čelutkienė, J., Yilmaz, M.B. and Coats, A.J.S. (2023) Heart Failure and the Heart-Brain Axis. QJM: An International Journal of Medicine, 116, 897-902. [Google Scholar] [CrossRef] [PubMed]
[42] Saeed, A., Lopez, O., Cohen, A. and Reis, S.E. (2023) Cardiovascular Disease and Alzheimer’s Disease: The Heart-Brain Axis. Journal of the American Heart Association, 12, e030780. [Google Scholar] [CrossRef] [PubMed]
[43] Pourhamzeh, M., Moravej, F.G., Arabi, M., Shahriari, E., Mehrabi, S., Ward, R., et al. (2021) The Roles of Serotonin in Neuropsychiatric Disorders. Cellular and Molecular Neurobiology, 42, 1671-1692. [Google Scholar] [CrossRef] [PubMed]
[44] Di Giovanni, G. and De Deurwaerdère, P. (2020) Serotonin Research: Crossing Scales and Boundaries. Neuropharmacology, 181, Article ID: 108340. [Google Scholar] [CrossRef] [PubMed]
[45] Sreeja, V., Jose, A., Patel, S., Menon, B., Athira, K.V. and Chakravarty, S. (2024) Pharmacogenetics of Selective Serotonin Reuptake Inhibitors (SSRI): A Serotonin Reuptake Transporter (SERT)-Based Approach. Neurochemistry International, 173, Article ID: 105672. [Google Scholar] [CrossRef] [PubMed]
[46] Marder, S.R. and Cannon, T.D. (2019) Schizophrenia. New England Journal of Medicine, 381, 1753-1761. [Google Scholar] [CrossRef] [PubMed]
[47] Kesby, J., Eyles, D., McGrath, J. and Scott, J. (2018) Dopamine, Psychosis and Schizophrenia: The Widening Gap between Basic and Clinical Neuroscience. Translational Psychiatry, 8, Article No. 30. [Google Scholar] [CrossRef] [PubMed]
[48] Weinstein, J.J., Chohan, M.O., Slifstein, M., Kegeles, L.S., Moore, H. and Abi-Dargham, A. (2017) Pathway-Specific Dopamine Abnormalities in Schizophrenia. Biological Psychiatry, 81, 31-42. [Google Scholar] [CrossRef] [PubMed]
[49] Kalueff, A.V. and Nutt, D.J. (2007) Role of GABA in Anxiety and Depression. Depression and Anxiety, 24, 495-517. [Google Scholar] [CrossRef] [PubMed]
[50] Duman, R.S., Sanacora, G. and Krystal, J.H. (2019) Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron, 102, 75-90. [Google Scholar] [CrossRef] [PubMed]
[51] Hassamal, S. (2023) Chronic Stress, Neuroinflammation, and Depression: An Overview of Pathophysiological Mechanisms and Emerging Anti-Inflammatories. Frontiers in Psychiatry, 14, Article 1130989. [Google Scholar] [CrossRef] [PubMed]
[52] Patel, V.K., Vaishnaw, A., Shirbhate, E., Kore, R., Singh, V., Veerasamy, R., et al. (2024) Cortisol as a Target for Treating Mental Disorders: A Promising Avenue for Therapy. Mini-Reviews in Medicinal Chemistry, 24, 588-600. [Google Scholar] [CrossRef] [PubMed]
[53] Lebedeva, A., Sundström, A., Lindgren, L., Stomby, A., Aarsland, D., Westman, E., et al. (2018) Longitudinal Relationships among Depressive Symptoms, Cortisol, and Brain Atrophy in the Neocortex and the Hippocampus. Acta Psychiatrica Scandinavica, 137, 491-502. [Google Scholar] [CrossRef] [PubMed]
[54] Elder, G.J., Wetherell, M.A., Barclay, N.L. and Ellis, J.G. (2014) The Cortisol Awakening Response—Applications and Implications for Sleep Medicine. Sleep Medicine Reviews, 18, 215-224. [Google Scholar] [CrossRef] [PubMed]
[55] Ravindran, A.V., Balneaves, L.G., Faulkner, G., Ortiz, A., McIntosh, D., Morehouse, R.L., et al. (2016) Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder. The Canadian Journal of Psychiatry, 61, 576-587. [Google Scholar] [CrossRef] [PubMed]
[56] Ye, Z., Zhu, L., Li, X., Gao, H., Wang, J., Wu, S., et al. (2023) PC6 Electroacupuncture Reduces Stress-Induced Autonomic and Neuroendocrine Responses in Rats. Heliyon, 9, e15291. [Google Scholar] [CrossRef] [PubMed]
[57] Zheng, J., Wang, Y., Zhang, C., Zhang, A., Zhou, Y., Xu, Y., et al. (2024) Electroacupuncture Negatively Regulates the Nesfat-in-1/ERK/CREB Pathway to Alleviate HPA Axis Hyperactivity and Anxiety-Like Behaviors Caused by Surgical Trauma. Chinese Medicine, 19, Article No. 108. [Google Scholar] [CrossRef] [PubMed]
[58] Min, Y.J., Yao, H.H., Wang, Z.Q., et al. (2023) Efficacy of Suspended Moxibustion Stimulating Shenshu (BL23) and Guanyuan (CV4) on the Amygdala-HPA Axis in Rats with Kidney-Deficiency Symptom Pattern Induced by Hydrocortisone. Journal of Traditional Chinese Medicine, 43, 113-123.
[59] Zhang, X., He, W., Wan, H., Su, Y., Yu, Q., Wang, Y., et al. (2021) Electroacupuncture and Moxibustion-Like Stimulation Activate the Cutaneous and Systemic Hypothalamic-Pituitary-Adrenal Axes in the Rat. Acupuncture in Medicine, 40, 232-240. [Google Scholar] [CrossRef] [PubMed]
[60] Zhang, Z.H., Zhu, J.Z., Ding, G.P., Wang, X.S., Zhong, Y.M., Wang, Y.P., et al. (2012) Role of Neuropeptide Y in Regulating Hypothalamus-Pituitary-Gonad Axis in the Rats Treated with Electro-Acupuncture. Neuropeptides, 46, 133-139. [Google Scholar] [CrossRef] [PubMed]
[61] Fu, H., Sun, J., Tan, Y., Zhou, H., Xu, W., Zhou, J., et al. (2018) Effects of Acupuncture on the Levels of Serum Estradiol and Pituitary Estrogen Receptor Beta in a Rat Model of Induced Super Ovulation. Life Sciences, 197, 109-113. [Google Scholar] [CrossRef] [PubMed]
[62] Zhao, H., Tian, Z., Cheng, L. and Chen, B. (2004) Electroacupuncture Enhances Extragonadal Aromatization in Ovariectomized Rats. Reproductive Biology and Endocrinology, 2, Article No. 18. [Google Scholar] [CrossRef] [PubMed]
[63] Lv, Z., Liu, R., Su, K., Gu, Y., Fang, L., Fan, Y., et al. (2022) Acupuncture Ameliorates Breast Cancer-Related Fatigue by Regulating the Gut Microbiota-Gut-Brain Axis. Frontiers in Endocrinology, 13, Article 921119. [Google Scholar] [CrossRef] [PubMed]
[64] Shi, J., Zhang, X., Chen, J., Shen, R., Cui, H. and Wu, H. (2024) Acupuncture and Moxibustion Therapy for Cognitive Impairment: The Microbiome-Gut-Brain Axis and Its Role. Frontiers in Neuroscience, 17, Article 1275860. [Google Scholar] [CrossRef] [PubMed]
[65] Guo, J., Guo, J., Rao, X., Zhang, R., Li, Q., Zhang, K., et al. (2024) Exploring the Pathogenesis of Insomnia and Acupuncture Intervention Strategies Based on the Microbiota-Gut-Brain Axis. Frontiers in Microbiology, 15, Article 1456848. [Google Scholar] [CrossRef] [PubMed]
[66] Chen, S., Huang, L., Liu, G., Kang, J., Qian, Q., Wang, J., et al. (2023) Acupuncture Ameliorated Behavioral Abnormalities in the Autism Rat Model via Pathways for Hippocampal Serotonin. Neuropsychiatric Disease and Treatment, 19, 951-972. [Google Scholar] [CrossRef] [PubMed]
[67] Li, B., Li, Y., Xu, J., Huang, M., Wang, L., Zhang, D., et al. (2023) Mast Cell-Associated Serotonin in Acupoint Contributes to Acupuncture Analgesia in Arthritis Rats by Mediating ATP Release. Frontiers in Bioscience-Landmark, 28, Article 1. [Google Scholar] [CrossRef] [PubMed]
[68] Park, H., Ahn, S., Lee, H., Hahm, D., Kim, K. and Yeom, M. (2021) Acupuncture Ameliorates Not Only Atopic Dermatitis-Like Skin Inflammation but Also Acute and Chronic Serotonergic Itch Possibly through Blockade of 5-HT2 and 5-HT7 Receptors in Mice. Brain, Behavior, and Immunity, 93, 399-408. [Google Scholar] [CrossRef] [PubMed]
[69] Deuel, L.M. and Seeberger, L.C. (2020) Complementary Therapies in Parkinson Disease: A Review of Acupuncture, Tai Chi, Qi Gong, Yoga, and Cannabis. Neurotherapeutics, 17, 1434-1455. [Google Scholar] [CrossRef] [PubMed]
[70] Xiao, L., Yang, J., Wang, X., Ye, Y., Yang, N., Yan, C., et al. (2018) Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats. BioMed Research International, 2018, Article ID: 5423961. [Google Scholar] [CrossRef] [PubMed]
[71] Lin, L., Yu, L., Xiang, H., Hu, X., Yuan, X., Zhu, H., et al. (2019) Effects of Acupuncture on Behavioral Stereotypies and Brain Dopamine System in Mice as a Model of Tourette Syndrome. Frontiers in Behavioral Neuroscience, 13, Article 239. [Google Scholar] [CrossRef] [PubMed]
[72] Qiao, L., Liu, J., Tan, L., Yang, H., Zhai, X. and Yang, Y. (2017) Effect of Electroacupuncture on Thermal Pain Threshold and Expression of Calcitonin-Gene Related Peptide, Substance P and γ-Aminobutyric Acid in the Cervical Dorsal Root Ganglion of Rats with Incisional Neck Pain. Acupuncture in Medicine, 35, 276-283. [Google Scholar] [CrossRef] [PubMed]
[73] Itriyeva, K. (2022) Premenstrual Syndrome and Premenstrual Dysphoric Disorder in Adolescents. Current Problems in Pediatric and Adolescent Health Care, 52, Article ID: 101187. [Google Scholar] [CrossRef] [PubMed]
[74] Li, X., Zhu, Y., Sun, H., Shen, Z., Sun, J., Xiao, S., et al. (2023) Electroacupuncture Inhibits Pain Memory and Related Anxiety-Like Behaviors by Blockading the GABAB Receptor Function in the Midcingulate Cortex. Molecular Neurobiology, 60, 6613-6626. [Google Scholar] [CrossRef] [PubMed]
[75] Cai, M., Park, H.R. and Yang, E.J. (2023) Electroacupuncture Modulates Glutamate Neurotransmission to Alleviate PTSD-Like Behaviors in a PTSD Animal Model. Translational Psychiatry, 13, Article No. 357. [Google Scholar] [CrossRef] [PubMed]
[76] Yang, P., Chen, H., Wang, T., Su, H., Li, J., He, Y., et al. (2023) Electroacupuncture Promotes Synaptic Plasticity in Rats with Chronic Inflammatory Pain-Related Depression by Upregulating BDNF/TrkB/CREB Signaling Pathway. Brain and Behavior, 13, e3310. [Google Scholar] [CrossRef] [PubMed]
[77] Chen, H., Zhang, M., Wu, J., She, Y., Yuan, X., Huo, Y., et al. (2022) Effect of Auricular Acupoint Bloodletting Plus Auricular Acupressure on Sleep Quality and Neuroendocrine Level in College Students with Primary Insomnia: A Randomized Controlled Trial. Chinese Journal of Integrative Medicine, 28, 1096-1104. [Google Scholar] [CrossRef] [PubMed]